Results 191 to 200 of about 190,941 (249)

Identification of aHighly Cooperative PROTAC DegraderTargeting GTP-Loaded KRAS(On) Alleles

Vesna Vetma (7953920), Ilaria Puoti (18965718), Natalia K. Karolak (22531394), Sohini Chakraborti (10736907), Emelyne Diers (2112991), Enrico Girardi (78640), Shakil Khan (22531397), Giorgia Kidd (18965715), Katrin G. Kropatsch (22531400), Ross Mclennan (22531403), Suzanne O’Connor (22531406), Matthias Samwer (19333201), Nicole Trainor (2094256), Claire Whitworth (323999), Andre J. Wijaya (22531409), Jeff Y. F. Wong (22531412), David Zollman (4751685), William Farnaby (2297479), Johannes Popow (6388691), Alessio Ciulli (762789), Peter Ettmayer (3013665), Kirsten McAulay (8921045)   +21 more
openalex   +1 more source

Structural and functional dissection of the WH2/DAD motif of INF2, a formin linked to human inherited degenerative disorders

The FEBS Journal, EarlyView.
The INF2 WH2/DAD domain, composed of hydrophobic and basic regions, forms a single α‐helix in solution. The hydrophobic segment is essential for INF2 function, as its deletion disrupts actin dynamics and causes nuclear abnormalities, like those seen in pathogenic INF2 DID variants. In contrast, natural INF2 WH2/DAD variants found in patients with renal
Leticia Labat‐de‐Hoz, Laura Fernández‐Martín, Paula Morales, Isabel Correas, María Ángeles Jiménez, Miguel Angel Alonso   +5 more
wiley   +1 more source

The mechanisms by which RhoA activity and associated synaptic effects are controlled by the DISC1 scaffolding-like protein. [PDF]

Biol Psychiatry
Bjornson KJ, Cahill ME.
europepmc   +1 more source

Binding of Bacillus subtilis dynamin‐like protein DynA to the bacterial membrane is essential for effective phage defense

The FEBS Journal, EarlyView.
The bacterial dynamin‐like protein DynA from Bacillus subtilis plays a key role in phage defense. It binds the plasma membrane through a unique paddle domain in its D1 subunit. This membrane association is essential for its protective function, likely preventing explosive membrane rupture following phage infection.
Samia Shafqat, Urska Repnik, Marc Bramkamp   +2 more
wiley   +1 more source

Mechanism of controlled radical initiation in radical SAM GTP 3',8-cyclase. [PDF]

Proc Natl Acad Sci U S A
Pang H, Li D, Wu Q, Zhang P, Yang W, Silakov A, Zhou P, Yokoyama K.   +7 more
europepmc   +1 more source

The importin‐alpha superfamily engages in ethylene signaling by shuttling ETHYLENE INSENSITIVE 2 from the endoplasmic reticulum to the nucleus

The FEBS Journal, EarlyView.
The plant hormone ethylene regulates plant growth, ripening, senescence, and stress responses. The hormonal signal transmission, from receptors at the ER membrane to the transcriptional regulators in the nucleus, is still not completely understood.
Fabian Wynen, Jan Eric Maika, Raphael Josef Eberle, Nina Jahnke, Marcel Wiermer, Laura Hartmann, Rüdiger Simon, Georg Groth   +7 more
wiley   +1 more source

Phosphorylation at S1288 of leukemia associated RhoGEF (LARG/ARHGEF12) induces plasma membrane localization and promotes binding and activation of RhoA. [PDF]

J Biol Chem
Yang WS, Ghanem NZ, Scahill SD, Caliva MJ, Röttig H, Fitz A, Matter ML, Ramos JW.   +7 more
europepmc   +1 more source

Dynamics of the CD9 interactome during bacterial infection of epithelial cells by proximity labelling proteomics

The FEBS Journal, EarlyView.
We describe the CD9 interactome in epithelial cells for the first time. The interactome is diverse and dynamic and changes dependent on infection with specific bacteria. We validate these data by showing functional interaction between CD9 with CD44 or CD147. We therefore demonstrate that CD9 is a universal organiser of bacterial adhesion platforms able
Paige A. Wolverson, Isabel Fernandes Parreira, Ruth H. Thompson, Mark O. Collins, Jonathan G. Shaw, Luke R. Green   +5 more
wiley   +1 more source

Global conformation of the Rag GTPase heterodimer governs eukaryotic amino acid sensing. [PDF]

Proc Natl Acad Sci U S A
Doxsey DD, Shen K.
europepmc   +1 more source

EHD4 and ASAP2 are critical negative regulators of the claudin‐5‐based endothelial barrier

The FEBS Journal, EarlyView.
Cell‐surface CLDN‐5 protein levels can be evaluated using a probe that can bind to the extracellular domains of CLDN‐5. A probe derived from Clostridium perfringens enterotoxin allows us to isolate cells with high CLDN‐5 protein levels from a knockout cell library.
Yosuke Hashimoto, Gergő Porkoláb, Natalie Hudson, Jeffrey O'Callaghan, Nicole Hanley, Conor Delaney, Mária A. Deli, Peter Westenskow, Matthew Campbell   +8 more
wiley   +1 more source