Results 221 to 230 of about 190,941 (249)

scRNA‐Seq reveals anti‐lymphoma immune responses in mogamulizumab‐associated skin eruptions

Journal of the European Academy of Dermatology and Venereology, EarlyView.
CCR4 was expressed in malignant clones and regulatory T cells in untreated CTCL, that were decreased in MAR. Malignant clones in MAR showed a silenced phenotype with decreases in central memory markers SELL and CCR7, and GTP‐binding member GIMAP7 and upregulation of MMP2 inhibitor TIMP2 and tumour suppressor gene RUNX3.
Shannon Meledathu, Agata Kurowski, Malini P. Naidu, Jonas Adalsteinsson, Shane A. Meehan, Natalia Alkon, Lauren R. Port, Sumanth Chennareddy, Emry R. Cohenour, Grace Christensen, Jonah Shulman, Nicholas Gulati, Constanze Jonak, Patrick M. Brunner   +13 more
wiley   +1 more source

Atypical GNAO1 variants in severe childhood speech disorders: clinical, genetic, and molecular insights. [PDF]

Mol Autism
Larasati YA, Thiel M, Salazar-Villacorta A, Koval A, Kurian MA, Koy A, Morgan AT, Katanaev VL, Solis GP.   +8 more
europepmc   +1 more source

Molecular insights into electroreceptor ribbon synapses from differential gene expression in sturgeon lateral line organs

Journal of Anatomy, EarlyView.
The expression of various genes involved in synapse development, stability and/or function was studied in developing mechanosensory neuromasts and electrosensory ampullary organs in sterlet sturgeon. Most were shared, including Slc17a8, Slc1a3 and Nrxn3, but Cbln18 was neuromast‐restricted and Tulp1 was ampullary organ‐restricted.
Alexander S. Campbell, Martin Minařík, David Buckley, Tanmay Anand, David Gela, Martin Pšenička, Clare V. H. Baker   +6 more
wiley   +1 more source

New insights into the classification of the RAC1 P29S hotspot mutation in melanoma as an oncogene. [PDF]

Cancer Gene Ther
Mirzaiebadizi A, Ahmadian MR.
europepmc   +1 more source

Cell‐type‐specific gating of gene regulatory modules as a hallmark of early immune responses in Arabidopsis leaves

New Phytologist, EarlyView.
Summary In plants, multiple cell types contribute to immunity, but what division of labor exists among cell types when immunity is activated? We compared, at single‐cell resolution, the response of Arabidopsis thaliana leaf cells during pattern‐triggered and effector‐triggered immunity (PTI/ETI), sampled at 3 and 5 h after infection with Pseudomonas ...
Shanshan Wang, Ilja Bezrukov, Pin‐Jou Wu, Hannah Gauß, Marja Timmermans, Detlef Weigel   +5 more
wiley   +1 more source

RHOA lactylation at oncogenic hotspots promotes oncogenic activity and protein stabilization. [PDF]

Mol Cancer
Ma C, Liao R, Chen X, Cao Q, Deng X, Dai Z, Dong C.   +6 more
europepmc   +1 more source

Join the Green and Sustainable Team: Magnesium Oxide Nanoparticles Boost Broad‐Spectrum Viral Resistance in Solanaceae Plants

Plant Biotechnology Journal, EarlyView.
ABSTRACT Plant viruses are so harmful to crops. It is an urgent need to develop modern, environment‐friendly, and sustainable plant viral epidemic‐management strategies that are safe for both human health and the environment. The field of nanotechnology is gaining increased interest in plant science.
Xiao‐Wen Wang, Li Ling, Ke‐Zheng Zhao, Jiangqi Wen, Zhaolin Ji, Xiao‐Ren Chen, Feng Zhu   +6 more
wiley   +1 more source

Structural mechanisms for cold-adapted activity of phosphoenolpyruvate carboxykinase. [PDF]

Protein Sci
McLeod MJ, Yazdani S, Barwell SAE, Holyoak T.   +3 more
europepmc   +1 more source

A GmeIF2B5‐GmPRX4 Regulatory Axis Divergently Governs Drought‐Lignin and Salt‐Ion Homeostasis in Soybean

Plant Biotechnology Journal, EarlyView.
ABSTRACT Abiotic stresses severely constrain soybean productivity worldwide. Here we demonstrate that gmeif2b5 (eukaryotic initiation factors) mutants confer dual stress tolerance through coordinated mechanisms. Integrative RNA‐Seq and protein interaction analyses revealed that gmeif2b5 mutants increase lignin deposition to increase drought resilience ...
Juan Liu, Yanzhong Huang, Xiaowan Fang, Han Gou, Huidong Xuan, Sushuang Deng, Lu Li, Yanjia Wang, Xiushuai Wang, Ling Gan, Nannan Zhang, Haoran Luo, Yaolan Bai, Qin Liu, Han Xing, Jinming Zhao, Na Guo   +16 more
wiley   +1 more source

Spatiotemporal coupling of caveolae mechanosensing and RhoA-GEFs regulates cell polarity and directional migration. [PDF]

Nat Commun
Singh V, Breton V, Viaris de Lesegno C, Macé AS, Bun P, Blouin CM, Vishen AS, Sens P, Lamaze C.   +8 more
europepmc   +1 more source