Results 291 to 300 of about 374,227 (387)

The accuracy of protein biosynthesis is limited by its speed: high fidelity selection by ribosomes of aminoacyl-tRNA ternary complexes containing GTP[gamma S]

, 1982
Richard Thompson, Amr M. Karim
openalex   +1 more source

Targeting TRPV4 to restore glymphatic system function and alleviate cerebral edema in ischemic stroke

Brain Pathology, EarlyView.
After ischemic stroke, TRPV4 activation induces cerebral edema through the TRPV4‐RhoA‐MMP9 axis: RhoA upregulates MMP9, which cleaves β‐DG to impair membrane anchoring. Subsequent β‐DG loss triggers AQP4 depolarization, disrupting GS‐mediated water homeostasis.
Yongchuan Li, Haiping Zhou, Jiaxin Xie, Mingjia Yu, Guanyu Ye, Yuzhen Zhang, Zhentong Li, Kunxue Zhang, Jingwen Wu, Sheng Xiao, Shuxin Zeng, Yuan Chang, Kaibin Huang, Suyue Pan   +13 more
wiley   +1 more source

Green respiratory healthcare: what really matters. [PDF]

Thorax
Connett G, Slingo M, Sinha I, Slingo DJ.
europepmc   +1 more source

Evidence that Bacillus subtilis sporulation induced by the stringent response is caused by the decrease in GTP or GDP

, 1982
Kozo Ochi, J C Kandala, Ernst Freese
openalex   +1 more source

The fast‐dissociating D2 antagonist antipsychotic JNJ‐37822681 is a neuronal Kv7 channel opener: Potential repurposing for epilepsy treatment

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Pharmacological activation of neuronal M‐current mediated by Kv7 (Kv7.2–5) potassium channels is a validated mechanism for epilepsy treatment. However, since the market withdrawal of the prototype Kv7 activator retigabine, no Kv7 activator is clinically available for this condition.
Lidia Carotenuto, Oliver Keminer, Giusy Carleo, Andrea Zaliani, Antonio Leo, Rita Citraro, Giovambattista De Sarro, Nina Dirkx, Marcus Kaji, Sarah Weckhuysen, Jeanette Reinshagen, Vincenzo Barrese, Natascia Guida, Carmine Ostacolo, Francesco Miceli, Philip Gribbon, Maurizio Taglialatela   +16 more
wiley   +1 more source

The RhoGDIβ-Rac1-CARD9 Signaling Module Mediates Islet β-Cell Dysfunction Under Chronic Hyperglycemia. [PDF]

Cells
Kowluru A, Wang JM.
europepmc   +1 more source

An employment-based route into teaching : an overview of the first year of the inspection of designated recommended bodies for the Graduate Teacher Programme 200 [PDF]

, 2005

core  

Development of opiate receptors and GTP-binding regulatory proteins in neonatal rat brain.

, 1987
Graeme Milligan, Richard A. Streaty, Peter Gierschik, Allen M. Spiegel, Werner A. Klee   +4 more
openalex   +1 more source

Compartmentalisation in cAMP signalling: A phase separation perspective

British Journal of Pharmacology, EarlyView.
Cells rely on precise spatiotemporal control of signalling pathways to ensure functional specificity. The compartmentalisation of cyclic AMP (cAMP) and protein kinase A (PKA) signalling enables distinct cellular responses within a crowded cytoplasmic space.
Milda Folkmanaite, Manuela Zaccolo
wiley   +1 more source

A GTP-binding regulatory component of adenylate cyclase and GTP hydrolysis in myelin

Japanese Journal of Pharmacology, 1982
Takeo Asakawa, Kazuko Hayama, Keiichi Enomoto, Makie Higuchi   +3 more
openaire   +2 more sources