Results 301 to 310 of about 374,227 (387)

Non‐canonical PKG1 regulation in cardiovascular health and disease

British Journal of Pharmacology, EarlyView.
It is well established that the cyclic GMP‐dependent protein kinase I (PKG1) is canonically activated by cyclic guanosine monophosphate (cGMP), enabling its regulation of vascular tone, cardiac function and smooth muscle homeostasis. However, diverse non‐canonical stimuli of PKG1 have also been identified.
Jie Su, Joseph Robert Burgoyne
wiley   +1 more source

Regulation of hormone-receptor coupling to adenylyl cyclase. Effects of GTP and GDP.

, 1980
Ravi Iyengar, Joel Abramowitz, M. Bordelon-Riser, Arthur J. Blume, Lutz Birnbaumer   +4 more
openalex   +1 more source

Case Report: Association of Ocular Colobomas With a Novel Missense Variant in CDC42, a Member of the Rho Family of Small GTPases

Clinical Genetics, EarlyView.
We report a 2‐year‐old male with clinical features of Takenouchi‐Kosaki syndrome, bilateral colobomas, and a de novo, likely pathogenic missense variant in CDC42. Supportive evidence includes a Cdc42 conditional knock‐out mouse model with colobomas.
Diana Brightman, Nawaal Shinwari, Aleksey Porollo, Eniolami O. Dosunmu, Ehsan Ullah, Bin Guan, Robert B. Hufnagel, Brian P. Brooks, Delphine Blain, Sabine Fuhrmann, Brittany Simpson, Anne M. Slavotinek   +11 more
wiley   +1 more source

Evolution of structure-guided drug design strategies targeting mutations in codon 12 of KRAS. [PDF]

RSC Med Chem
Dorandish S, Bhayekar K, Singh A, Kushwaha ND, Malin E, Serafimovski S, Kelm JM, Gavande NS, Lakkaniga NR.   +8 more
europepmc   +1 more source

Steady-state theory of the interference of GTP hydrolysis in the mechanism of microtubule assembly.

, 1983
Terrell L. Hill, M F Carlier
openalex   +1 more source

Unraveling the Role of WDR91: Case Report of a Previously Unrecognized Clinical Entity

Clinical Genetics, EarlyView.
A novel case is herein described to expand the genetic and clinical spectrum of WDR91 and characterize a previously unrecognized autosomal recessive neurodevelopmental disorder. WDR91 deficiency results in neuronal loss, cortical thinning, and impaired brain development.
Nikolaos M. Marinakis, Afrodite Kampouraki, Danai Veltra, Faidon‐Nikolaos Tilemis, Maria Vasilopoulou, Aikaterini Dokou, Elissavet Georgiadou, Euthalia Karavergou, Maria Christolouka, Alexis Alexopoulos, Dimitra Kirillidi, Maria Goudesidou, Konstantina Kosma, Christalena Sofocleous, Periklis Makrythanasis   +14 more
wiley   +1 more source

Structure-guided engineering of a polyphosphate kinase 2 class III from an <i>Erysipelotrichaceae</i> bacterium to produce base-modified purine nucleotides. [PDF]

RSC Chem Biol
Mitton-Fry RM, Rasche R, Lawrence-Dörner AM, Eschenbach J, Tekath A, Rentmeister A, Kümmel D, Cornelissen NV.   +7 more
europepmc   +1 more source

Funding manual : employment-based initial teacher training : for academic year 2011/12 [PDF]

, 2011

core  

Research Advances of the Autophagy‐Regulated Radiosensitivity

Cell Proliferation, EarlyView.
Autophagy plays a dual role in regulating cellular radiosensitivity in radiotherapy (RT). We discuss the mechanisms by which autophagy promotes survival and growthsuppression by modulating radiosensitivity. It also outlines some frontier autophagy‐targeted radiotherapies. ABSTRACT Autophagy is an evolutionarily conserved process of cell self‐catabolism
Hanyue Liu, Yanlan Xiao, Chuhao Dai, Keyu Chen, Xinyi Xu, Jianming Cai, Xuguang Hu, Jiaming Guo   +7 more
wiley   +1 more source

An Alternative Mechanism of Glutamate Dehydrogenase Inhibition by EGCG: Promotion of Protein Degradation. [PDF]

Pharmaceuticals (Basel)
Zeng Z, Lin C, Pan C, Chen Z, Ruan BH.
europepmc   +1 more source