Results 301 to 310 of about 386,929 (385)

Melanoma Diagnosis in the Mihm Era—And Beyond

Journal of Cutaneous Pathology, EarlyView.
ABSTRACT During the illustrious career of Martin C. Mihm Jr., MD, the diagnosis of melanoma underwent significant changes, to which he made many contributions. In early descriptions, melanomas were fungating tumor masses that were obviously malignant, and highly lethal. In seminal work by Dr. Mihm and his mentor, Wallace H.
David E. Elder
wiley   +1 more source

Screening of gene function in cell intoxication by CNF1 links Sec61 translocon to Rac1 GTPase activity. [PDF]

mBio
Paillares E, Deboosere N, Descorps-Declere S, Marechal M, Gillet D, Demangel C, Mettouchi A, Brodin P, Lemichez E.   +8 more
europepmc   +1 more source

Evaluation of the graduate talent pool internships scheme (BIS research paper number 28) [PDF]

, 2011
Day, Emma, Mellors-Bourne, Robin
core  

Efficacy and safety of switching to ezetimibe 10 mg/rosuvastatin 2.5 mg in Korean patients with type 2 diabetes mellitus and dyslipidaemia: A multicentre, prospective study (EROICA study)

Diabetes, Obesity and Metabolism, EarlyView.
Abstract Aims To evaluate the lipid‐lowering efficacy, safety, and adherence of switching from moderate‐ or low‐intensity statin monotherapy to ezetimibe 10 mg/rosuvastatin 2.5 mg in Korean patients with type 2 diabetes mellitus (T2DM) and dyslipidaemia.
Sangmo Hong, Won J. Kim, Sungrae Kim, Jung H. Park, Eun S. Kang, Min K. Moon, Jae T. Kim, Ji‐Oh Mok, Ki Y. Lee, Cheol‐Young Park, Chang B. Lee   +10 more
wiley   +1 more source

Assessment of Hepatic Safety of Ulipristal Acetate in Korean Women with Uterine Fibroids: A Real-World Study Using Biochemical Markers. [PDF]

J Clin Med
Park JY, Namkung J, Seo YH, Chung Y.
europepmc   +1 more source

Employment-based initial teacher training : operational manual 2012/13 [PDF]

, 2012

core  

Taxonomic and functional shifts in the microbiome of severely obese, prediabetic patients: Ketogenic diet versus energy‐matched standard diet

Diabetes, Obesity and Metabolism, EarlyView.
Abstract Aims Obesity and type 2 diabetes mellitus (T2DM) are among the leading global health challenges of the 21st century. While caloric restriction remains the cornerstone of weight loss interventions, ketogenic diets (KD), characterised by low carbohydrate and high fat intake, have been shown to improve metabolic health partly by modulating the ...
June Stone, Afroditi Tripyla, Melanie C. Scalise, Maria L. Balmer, Lia Bally, Dominik M. Meinel   +5 more
wiley   +1 more source

Identification and characterization of binders to a cryptic and functional pocket in KRAS. [PDF]

Nat Commun
Beyer KS, Klein J, Katz S, Welker P, Lanter M, Guthy D, Pollehn K, Gluck-Gadé A, Bleu M, Desogus J, Hattenberger M, Borrello D, Abdul Rahman W, Zink F, Ostermann N, Jahnke W, Dumelin CE, Leder L, Esser O, Muller L, Marzinzik A, Cébé R, Müller K, Galli GG, Tordella L, Cotesta S, Brachmann SM, Maira SM.   +27 more
europepmc   +1 more source

Evolutionary divergence and functional insights into the heteromeric cis‐prenyltransferase of Paramecium tetraurelia

The FEBS Journal, EarlyView.
Heteromeric cis‐prenyltransferases (CPT) are indispensable for dolichol synthesis and protein N‐glycosylation in most eukaryotes. The catalytic subunits are strongly conserved throughout evolution, in contrast to the evolutionarily variable accessory subunits. The POC1 protein from Paramecium tetraurelia is the smallest identified CPT‐accessory subunit
Agnieszka Onysk, Kamil Steczkiewicz, Mariusz Radkiewicz, Paweł Link‐Lenczowski, Przemysław Surowiecki, Karolina Sztompka, Kariona A. Grabińska, Jacek K. Nowak, Liliana Surmacz   +8 more
wiley   +1 more source

The rapidly growing landscape of RAS inhibitors: from selective allele blockade to broad inhibition strategies. [PDF]

Mol Oncol
Drosten M, Barbacid M.
europepmc   +1 more source