Results 31 to 40 of about 221,192 (198)

Parkinson’s disease in GTP cyclohydrolase 1 mutation carriers

Brain : a journal of neurology, 2014
Mutations in the gene encoding the dopamine-synthetic enzyme GTP cyclohydrolase-1 (GCH1) cause DOPA-responsive dystonia (DRD). Mencacci et al. demonstrate that GCH1 variants are associated with an increased risk of Parkinson's disease in both DRD ...
N. Mencacci, N. Mencacci, I. Isaias, M. Reich, C. Ganos, C. Ganos, V. Plagnol, J. Polke, J. Bras, J. Hersheson, M. Stamelou, M. Stamelou, A. Pittman, A. Noyce, K. Mok, T. Opladen, E. Kunstmann, Sybille Hodecker, A. Münchau, J. Volkmann, S. Samnick, K. Sidle, Tina Nanji, M. Sweeney, H. Houlden, A. Batla, A. Zecchinelli, G. Pezzoli, G. Marotta, A. Lees, P. Alegria, P. Krack, F. Cormier‐Dequaire, S. Lesage, A. Brice, P. Heutink, T. Gasser, S. Lubbe, H. Morris, P. Taba, S. Kõks, E. Majounie, J. R. Gibbs, A. Singleton, J. Hardy, S. Klebe, K. Bhatia, N. Wood   +47 more
semanticscholar   +1 more source

The geometry of GTPs and 5d SCFTs

Journal of High Energy Physics
Abstract We make progress in understanding the geometry associated to the Generalized Toric Polygons (GTPs) encoding the Physics of 5d Superconformal Field Theories (SCFTs), by exploiting the connection between Hanany-Witten transitions and the mathematical notion of polytope mutations. From this correspondence, it follows that the
Guillermo Arias-Tamargo, Sebastián Franco, Diego Rodríguez-Gómez   +2 more
openaire   +3 more sources

Reconstitution of microtubule into GTP-responsive nanocapsules

Nature Communications, 2022
AbstractNanocapsules that collapse in response to guanosine triphosphate (GTP) have the potential as drug carriers for efficiently curing diseases caused by cancer and RNA viruses because GTP is present at high levels in such diseased cells and tissues.
Noriyuki Uchida, Ai Kohata, Kou Okuro, Annalisa Cardellini, Chiara Lionello, Eric A. Zizzi, Marco A. Deriu, Giovanni M. Pavan, Michio Tomishige, Takaaki Hikima, Takuzo Aida   +10 more
openaire   +3 more sources

A multidrug ABC transporter with a taste for GTP [PDF]

Scientific Reports, 2018
AbstractDuring the evolution of cellular bioenergetics, many protein families have been fashioned to match the availability and replenishment in energy supply. Molecular motors and primary transporters essentially need ATP to function while proteins involved in cell signaling or translation consume GTP.
Orelle, Cedric, Durmort, Claire, Mathieu, Khadija, Duchêne, Benjamin, Aros, Sandrine, Fenaille, François, André, François, Junot, Christophe, Vernet, Thierry, Jault, Jean-Michel   +9 more
openaire   +5 more sources

Cooperative Recruitment of Dynamin and BIN/Amphiphysin/Rvs (BAR) Domain-containing Proteins Leads to GTP-dependent Membrane Scission*♦

Journal of Biological Chemistry, 2013
Background: Dynamin and BAR domain proteins are major components of clathrin-mediated endocytosis and other membrane-trafficking events. Results: Dynamin is recruited to membranes by BAR domain proteins, which in turn rely on interaction with dynamin to ...
M. Meinecke, Emmanuel Boucrot, Gamze Ö. Çamdere, W. Hon, Rohit Mittal, H. McMahon   +5 more
semanticscholar   +1 more source

GTP Is the Primary Activator of the Anti-HIV Restriction Factor SAMHD1*

Journal of Biological Chemistry, 2013
Background: dGTP allosterically activates SAMHD1. Results: GTP can also efficiently activate SAMHD1. Conclusion: The cellular concentration of GTP is much higher than that of dGTP, and GTP can activate SAMHD1 to the same extent.
Sarah M. Amie, R. Bambara, Baek Kim
semanticscholar   +1 more source

Dual use of GTP hydrolysis by elongation factor G on the ribosome

Translation, 2013
Elongation factor G (EF-G) is a GTPase that catalyzes tRNA and mRNA translocation during the elongation cycle of protein synthesis. The GTP-bound state of the factor on the ribosome has been studied mainly with non-hydrolyzable analogs of GTP, which led ...
C. E. Cunha, R. Belardinelli, F. Peske, W. Holtkamp, W. Wintermeyer, M. Rodnina   +5 more
semanticscholar   +1 more source

RNA-dependent RNA polymerase of Japanese encephalitis virus binds the initiator nucleotide GTP to form a mechanistically important pre-initiation state

Nucleic Acids Research, 2013
Flaviviral RNA-dependent RNA polymerases (RdRps) initiate replication of the single-stranded RNA genome in the absence of a primer. The template sequence 5′-CU-3′ at the 3′-end of the flaviviral genome is highly conserved.
P. Surana, V. Satchidanandam, Deepak T. Nair   +2 more
semanticscholar   +1 more source

Uncoupling of GTP hydrolysis from eIF6 release on the ribosome causes Shwachman-Diamond syndrome.

Genes & Development, 2011
Removal of the assembly factor eukaryotic initiation factor 6 (eIF6) is critical for late cytoplasmic maturation of 60S ribosomal subunits. In mammalian cells, the current model posits that eIF6 release is triggered following phosphorylation of Ser 235 ...
A. Finch, C. Hilcenko, N. Basse, L. Drynan, B. Goyenechea, T. Menne, Africa González Fernández, P. Simpson, C. D’Santos, M. Arends, J. Donadieu, C. Bellanné-Chantelot, M. Costanzo, Charles Boone, A. McKenzie, S. Freund, A. Warren   +16 more
semanticscholar   +1 more source

Effect of GTP on the dissociation of 70 S ribosomes [PDF]

, 1969
Nélida S. González, Ernesto G. Bade, Israel D. Algranati   +2 more
openalex   +1 more source