Results 41 to 50 of about 386,929 (385)
KRAS G13D sensitivity to neurofibromin-mediated GTP hydrolysis
Proceedings of the National Academy of Sciences of the United States of America, 2019 Significance The protooncogene KRAS, a GTPase, is responsible for activating the MAPK pathway. Cancer mutations at codons 12, 13, or 61 are thought to stabilize KRAS-GTP primarily by preventing GAP protein-stimulated GTP hydrolysis, thereby stabilizing ...
Dana Rabara +6 more
semanticscholar +1 more source
Analysis of GTP-binding potein function with a photoaffinity GTP analog.
Folia Pharmacologica Japonica, 1995 The mechanism whereby hormones or neurotransmitters activate G proteins and their intracellular effectors can be studied in reconstituted systems using purified components. However, the regulation of receptor-G protein signaling appears to be substantially more complex in the cell and several additional components participate in this event.
S, Hatta, H, Ohshika
openaire +3 more sources
The Journal of Poultry Science, 2001 Responses of broiler to dietary Japanese green tea powder (GTP) were investigated using 30 broiler chicks reared from 18 to 52 days of age. Five rations were formulated by addition of 0, 0.5, 0.75, 1.0 and 1.5% of GTP to starter and finisher diets, and ...
Abdul Hai Biswas, Masaaki Wakita
doaj +1 more source
Virology Journal, 2021 Background Peste des petits ruminants (PPR) and goat pox (GTP) are two devastating animal epidemic diseases that affect small ruminants. Vaccination is one of the most important measures to prevent and control these two severe infectious diseases ...
Dajun Zhang +7 more
doaj +1 more source
Effect of GTP and Ca2+ on inositol 1,4,5-trisphosphate induced Ca2+ release from permeabilized rat exocrine pancreatic acinar cells [PDF]
, 1991 The effects of Ca2+ and GTP on the release of Ca2+ from the inositol 1,4,5-trisphosphate (IP3) sensitive Ca2+ compartment were investigated with digitonin permeabilized rat pancreatic acinar cells.
Ammann +30 more
core +1 more source
Blocking entry of hepatitis B and D viruses to hepatocytes as a novel immunotherapy for treating chronic infections [PDF]
, 2021 Background. Chronic hepatitis B and D virus (HBV/HDV) infections can cause cancer. Current HBV therapy using nucleoside analogues (NAs) is life-long and reduces but does not eliminate the risk of cancer.
Ahlén, G +13 more
core +1 more source
GTP cyclohydrolase I utilizes metal‐free GTP as its substrate [PDF]
European Journal of Biochemistry, 2003 GTP cyclohydrolase I (GCH) is the rate‐limiting enzyme for the synthesis of tetrahydrobiopterin and its activity is important in the regulation of monoamine neurotransmitters such as dopamine, norepinephrine and serotonin. We have studied the action of divalent cations on the enzyme activity of purified recombinant human GCH expressed in Escherichia ...
T. Suzuki, H. Kurita, H. Ichinose
openaire +2 more sources
Severing enzymes amplify microtubule arrays through lattice GTP-tubulin incorporation
Science, 2018 Severing to build microtubules Microtubules are essential intracellular polymers, built from tubulin subunits, that establish cell shape, move organelles, and segregate chromosomes during cell division. Vemu et al.
Annapurna Vemu +6 more
semanticscholar +1 more source
Mutations in human dynamin block an intermediate stage in coated vesicle formation [PDF]
, 1993 The role of human dynamin in receptor-mediated endocytosis was investigated by transient expression of GTP-binding domain mutants in mammalian cells. Using assays which detect intermediates in coated vesicle formation, the dynamin mutants were found to ...
Damke, Hanna +5 more
core +3 more sources
The speed of GTP hydrolysis determines GTP cap size and controls microtubule stability
bioRxiv, 2019 Microtubules are bistable cytoskeletal polymers whose function depends on their property to switch between states of growth and shrinkage 1. Growing microtubules are thought to be stabilized by a GTP cap at their ends 2-5. The nature of this cap, however,
Johanna Roostalu +5 more
semanticscholar +1 more source