Results 71 to 80 of about 328,032 (283)

Molecular modeling study for interaction between Bacillus subtilis Obg and Nucleotides. [PDF]

PLoS ONE, 2010
The bacterial Obg proteins (Spo0B-associated GTP-binding protein) belong to the subfamily of P-loop GTPase proteins that contain two equally and highly conserved domains, a C-terminal GTP binding domain and an N-terminal glycine-rich domain which is ...
Yuno Lee, Woo Young Bang, Songmi Kim, Prettina Lazar, Chul Wook Kim, Jeong Dong Bahk, Keun Woo Lee   +6 more
doaj   +1 more source

Growth and shortening of microtubules: a two-state model approach

, 2011
In this study, a two-state mechanochemical model is presented to describe the dynamic instability of microtubules (MTs) in cells. The MTs switches between two states, assembly state and disassembly state. In assembly state, the growth of MTs includes two
Akiyoshi, Armond, Asbury, Bell, Bray, Cooper, Derrida, Dogterom, Efremov, Fisher, Franck, Gao, Grill, Grishchuk, Hill, Howard, Howard, Howard, Janson, Joglekar, Joglekar, Jülicher, Kolomeisky, Kolomeisky, Kolomeisky, Koshland, McIntosh, Miranda, Molodtsov, Monod, Powers, Pury, Redner, Salmon, Schliwa, Schnitzer, Sperry, Vale, Verde, Walker, Walker, Westermann, Westermann, Yunxin Zhang, Zhang, Zhang   +45 more
core   +1 more source

Super‐Refractory Status Epilepticus (SRSE) in a Patient With Compound Heterozygous OPA1 Variants: Case Report and Literature Review

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Super‐Refractory Status Epilepticus (SRSE) is a rare, life‐threatening neurological emergency with unclear etiology in many cases. Mitochondrial dysfunction, often due to disease‐causing genetic variants, is increasingly recognized as a cause, with each gene producing distinct pathophysiological mechanisms.
Pouria Mohammadi, Lara Basovic, Christopher Michael McGraw   +2 more
wiley   +1 more source

Mitigation of oxidative damage by green tea polyphenols and Tai Chi exercise in postmenopausal women with osteopenia. [PDF]

PLoS ONE, 2012
Osteoporosis is a degenerative bone disease predominantly in postmenopausal women. Green tea polyphenols (GTP) and Tai Chi (TC) have been shown to be beneficial on human bone health.
Guoqing Qian, Kathy Xue, Lili Tang, Franklin Wang, Xiao Song, Ming-Chien Chyu, Barbara C Pence, Chwan-Li Shen, Jia-Sheng Wang   +8 more
doaj   +1 more source

Game Transfer Phenomena in video game playing: a qualitative interview study [PDF]

, 2011
Video game playing is a popular activity and its enjoyment among frequent players has been associated with absorption and immersion experiences. This paper examines how immersion in the video game environment can influence the player during the game and ...
Aronsson, K, Griffiths, MD, Ortiz de Gortari, AB   +2 more
core  

Ultrasound‐Responsive Dual‐Prodrug Nanoassembly for “Fenestrae‐Restoration Strategy” in Liver Fibrosis Therapy

Advanced Materials, EarlyView.
ABSTRACT Liver fibrosis is a serious yet reversible intermediate stage in the progression of liver disease, which can ultimately advance to cirrhosis and hepatocellular carcinoma. Targeted and selective inhibition of activated hepatic stellate cells (aHSCs) has emerged as a promising therapeutic strategy for the treatment of liver fibrosis.
Shutong Liu, Mengyao Zhang, Zitong Qiu, Xinyi Liu, Yunsheng Dou, Sona Krizkova, Zheyi Li, Zbynek Heger, Nan Li   +8 more
wiley   +1 more source

Green tea polyphenols supplementation alters immunometabolism and oxidative stress in dairy cows with hyperketonemia

Animal Nutrition, 2021
Peripartal cows often experience negative energy balance, and are therefore prone to suffering from metabolic diseases such as hyperketonemia, which causes financial losses in dairy farms.
Yanfen Ma, Ying Feng, Liwen Song, Muyang Li, Hongyu Dai, Hua Bao, Guijie Zhang, Lei Zhao, Chunhua Zhang, Jing Yi, Yusheng Liang   +10 more
doaj   +1 more source

Exocytosis from permeabilized bovine adrenal chromaffin cells is differently modulated by guanosine 5'-[gamma-thio]triphosphate and guanosine 5'-[beta gamma-imido]triphosphate [PDF]

, 1992
1. In bovine adrenal chromaffin cells made permeable either to molecules less than or equal to 3 kDa with alphatoxin or to proteins less than or equal to 150 kDa with streptolysin O, the GTP analogues guanosine 5'-[beta gamma-imido]triphosphate (p[NH]ppG)
Ahnert-Hilger, G., Gratzl, Manfred, Rosenthal, W., Spicher, K., Stecher, B., Wegenhorst, U.   +5 more
core  

Chronic Hypoxia Disrupts Spermatogenesis Through ASXL2–EZH2–Mediated Microtubule Destabilization

Advanced Science, EarlyView.
This study reveals the mechanism by which chronic hypoxia impairs spermatogenesis via the ASXL2–EZH2 axis, hindering the transition of spermatids from round to elongated forms. Key findings reveal that under hypoxic conditions, downregulated ASXL2 expression reduces EZH2 binding to the CEP162 promoter, leading to decreased H3K27me3 modification and ...
Jun Yin, Mengjie Zhang, Wenying Liu, Wenlong Shen, Debao Li, Hongming Miao, Fang Deng, Gang Zhang, Yi Tian, Yi Zhang, Zhihu Zhao, Bing Ni   +11 more
wiley   +1 more source

Hydrolysis-deficient mosaic microtubules as faithful mimics of the GTP cap

Nature Communications
A critical feature of microtubules is their GTP cap, a stabilizing GTP-tubulin rich region at growing microtubule ends. Microtubules polymerized in the presence of GTP analogs or from GTP hydrolysis-deficient tubulin mutants have been used as GTP-cap ...
Juan Estévez-Gallego, Thorsten B. Blum, Felix Ruhnow, María Gili, Silvia Speroni, Raquel García-Castellanos, Michel O. Steinmetz, Thomas Surrey   +7 more
doaj   +1 more source