Results 51 to 60 of about 2,286 (161)
G12/13 Signaling in Asthma [PDF]
Shortening of airway smooth muscle and bronchoconstriction are pathognomonic for asthma. Airway shortening occurs through calcium-dependent activation of myosin light chain kinase, and RhoA-dependent calcium sensitization, which inhibits myosin light ...
McDuffie, Elizabeth L. +2 more
core +1 more source
Identification of Multiple Levels of Trauma Induced Coagulopathy [PDF]
, 2013 Trauma continues to be a major cause of death across the globe. While the exact causes of trauma differ greatly between the military and civilian lifestyles, the ability to stop bleeding after trauma is paramount for survival.
Newton, Jason
core +1 more source
G-protein and Rho GTPase signaling in endothelial barrier regulation [PDF]
, 2019 Endothelial cells (ECs) line all blood vessels and dynamically regulate the endothelial barrier function, which is critical for proper functioning of the vasculature and human health.
Reinhard, N.R.
core
Recognition of the activated states of Galpha13 by the rgRGS domain of PDZRhoGEF [PDF]
, 2008 G12 class heterotrimeric G proteins stimulate RhoA activation by RGS-RhoGEFs. However, p115RhoGEF is a GTPase Activating Protein (GAP) toward Galpha13, whereas PDZRhoGEF is not.
Chen, Zhe +4 more
core +1 more source
Serotonin 5-HT4 receptor boosts functional maturation of dendritic spines via RhoA-dependent control of F-actin [PDF]
, 2020 Activity-dependent remodeling of excitatory connections underpins memory formation in the brain. Serotonin receptors are known to contribute to such remodeling, yet the underlying molecular machinery remains poorly understood.
Abdel-Galil, D +17 more
core
, 2013 dissertationHeterotrimeric G-protein signaling pathways modulate synaptic transmission in response to secreted factors. For example, Go, the most abundant G protein in the nervous system, negatively regulates neuron activity by acting on potassium ...
Chen, Pin-An
core
Cloning, characterization and expression of A. thaliana G protein α-subunit gene for structural studies [PDF]
, 2003 A combined PCR-cloning strategy was implemented to express GPAl for structural studies. To begin with the presence of GPAl, which İs the ?-subunit of heterotrimeric G proteins from Arabidopsis thaliana, was checked with restriction enzyme digestion and ...
Bakkal, Suphan Emine +1 more
core
Neonatal Platelets: Lower G<sub>12/13</sub> Expression Contributes to Reduced Secretion of Dense Granules. [PDF]
Cells, 2022 Schlagenhauf A +6 more
europepmc +1 more source
Gα12 signaling regulates transcriptional and phenotypic responses that promote glioblastoma tumor invasion. [PDF]
Sci Rep, 2023 Chaim OM +12 more
europepmc +1 more source