Results 51 to 60 of about 2,709 (164)

G12/13 Signaling in Asthma [PDF]

Shortening of airway smooth muscle and bronchoconstriction are pathognomonic for asthma. Airway shortening occurs through calcium-dependent activation of myosin light chain kinase, and RhoA-dependent calcium sensitization, which inhibits myosin light ...
McDuffie, Elizabeth L., Panettieri, Reynold A, Scott, Charles P.   +2 more
core   +1 more source

Recognition of the activated states of Galpha13 by the rgRGS domain of PDZRhoGEF [PDF]

, 2008
G12 class heterotrimeric G proteins stimulate RhoA activation by RGS-RhoGEFs. However, p115RhoGEF is a GTPase Activating Protein (GAP) toward Galpha13, whereas PDZRhoGEF is not.
Chen, Zhe, Danesh, Shahab M, Singer, William D, Sprang, Stephen R, Sternweis, Paul C   +4 more
core   +1 more source

Identification of Multiple Levels of Trauma Induced Coagulopathy [PDF]

, 2013
Trauma continues to be a major cause of death across the globe. While the exact causes of trauma differ greatly between the military and civilian lifestyles, the ability to stop bleeding after trauma is paramount for survival.
Newton, Jason
core   +1 more source

Doctor of Philosophy [PDF]

, 2013
dissertationHeterotrimeric G-protein signaling pathways modulate synaptic transmission in response to secreted factors. For example, Go, the most abundant G protein in the nervous system, negatively regulates neuron activity by acting on potassium ...
Chen, Pin-An
core  

G proteins in adipocytes and preadipocytes: characterization, subcellular distribution, and potential roles for Gi2 and/or Gi3 in the control of cell proliferation.

Cellular Signalling, 1996
D. Denis-Henriot, P. de Mazancourt, P. Goldsmith, Y. Giudicelli   +3 more
semanticscholar   +1 more source

Cloning, characterization and expression of A. thaliana G protein α-subunit gene for structural studies [PDF]

, 2003
A combined PCR-cloning strategy was implemented to express GPAl for structural studies. To begin with the presence of GPAl, which İs the ?-subunit of heterotrimeric G proteins from Arabidopsis thaliana, was checked with restriction enzyme digestion and ...
Bakkal, Suphan Emine, Bakkal, Süphan Emine   +1 more
core  

Identification of a GTP-binding protein alpha subunit that lacks an apparent ADP-ribosylation site for pertussis toxin.

Proceedings of the National Academy of Sciences of the United States of America, 1988
H. Fong, K. Yoshimoto, P. Eversole-Cire, Melvin I. Simon   +3 more
semanticscholar   +1 more source

Myristoylation of an inhibitory GTP-binding protein alpha subunit is essential for its membrane attachment.

Proceedings of the National Academy of Sciences of the United States of America, 1990
Teresa L. Z. Jones, W. Simonds, J. J. Merendino, Mark R. Brann, Allen M. Spiegel   +4 more
semanticscholar   +1 more source

Étude des mécanismes de signalisation du récepteur à l’angiotensine II de type 2 [PDF]

, 2019
À eux seuls, les récepteurs couplés aux protéines G (GPCR) forment la plus grande famille de récepteurs et sont la cible du tiers de tous les médicaments approuvés par la FDA.
Connolly, Alexandre
core   +1 more source

Structural basis of adhesion GPCR GPR110 activation by stalk peptide and G-proteins coupling. [PDF]

Nat Commun, 2022
Zhu X, Qian Y, Li X, Xu Z, Xia R, Wang N, Liang J, Yin H, Zhang A, Guo C, Wang G, He Y.   +11 more
europepmc   +1 more source