Results 111 to 120 of about 154,453 (348)

A Non‐Mitophagy Activity of BNIP3L/NIX in Amygdala Glutamatergic Neurons is Essential for Contextual Fear Memory Formation

Advanced Science, EarlyView.
Contextual fear conditioning induces BNIP3L‐dependent mitochondrial fission in glutamatergic neurons of the BLA, independently of mitophagy. Loss of BNIP3L elevates Drp1Ser637 phosphorylation, thereby suppressing mitochondrial fission, compromising ATP production, and attenuating excitatory synaptic transmission.
Xingxian Zhang, Xinlei Mo, Xinyu Zhou, Xiaoliang Liu, Guizhi Li, Songhui Hu, Yangyang Lu, Chenze Zhu, Jinxi Feng, Zhitong Chen, Weiwei Hu, Yihui Cui, Zhong Chen, Xiangnan Zhang   +13 more
wiley   +1 more source

A Novel Binding Protein Composed of Homophilic Tetramer Exhibits Unique Properties for the Small GTPase Rab5*

Journal of Biological Chemistry, 2002
The small GTPase Rab family, which cycles between GTP-bound active and GDP-bound inactive states, plays an important role in membrane trafficking. Among them, Rab5 is involved in early endocytic pathway, and several Rab5-binding proteins have been ...
Kota Saito, J. Murai, H. Kajiho, K. Kontani, H. Kurosu, T. Katada   +5 more
semanticscholar   +1 more source

Cell‐Free DNA‐Based Theranostics for Inflammatory Disorders

Advanced Science, EarlyView.
Summary on the dual potential of cfDNA as biomarkers and therapeutic targets for inflammatory disorders. Figure was created with BioRender.com. ABSTRACT Inflammatory disorders are characterized by immune‐mediated inflammatory cascades that can affect multiple organs.
Jiatong Li, Yumei Wang, Xiaoxi Fan, Miao Xu, Jiawen Li, Wenfei Tan, Jianxiang Zhang, Heran Li   +7 more
wiley   +1 more source

Expression of MHC II genes

, 2005
Innate and adaptive immunity are connected via antigen processing and presentation (APP), which results in the presentation of antigenic peptides to T cells in the complex with the major histocompatibility (MHC) determinants.
Drozina, G., Jabrane-Ferrat, N., Kohoutek, J., Peterlin, B. M.   +3 more
core   +2 more sources

Gill transcriptome response to changes in environmental calcium in the green spotted puffer fish [PDF]

, 2010
Background Calcium ion is tightly regulated in body fluids and for euryhaline fish, which are exposed to rapid changes in environmental [Ca2+], homeostasis is especially challenging. The gill is the main organ of active calcium uptake and therefore plays
Canario, Adelino V. M., Matsumura, H., Pinto, Patricia IS, Power, Deborah, Reinhardt, Richard, Terauchi, Ryohei, Thorne, Michael A. S.   +6 more
core   +5 more sources

Targeting DAP5 Disrupts Alternate Mode of Translational Initiation in Tregs and Potentiates Antitumor Immunity

Advanced Science, EarlyView.
Regulatory T cells (Tregs) suppress antitumor immunity. This study identifies that the translation scaffold DAP5/eIF4G2 is upregulated in tumor‐infiltrating Tregs (ti‐Tregs). DAP5 mediates an alternate translation mode to sustain CD25 and MCL‐1 expression, which is critical for ti‐Treg stability and survival in the tumor microenvironment.
Xiaojiang Lai, Guihong Pan, Xixi Feng, Jun Zhang, Yunxia Li, Shanmeizi Zhao, Zhenming Lin, Yun Feng, Wei Bao, Hongyan Yang, Chengmei Xie, Chen Huang, Jun Wang   +12 more
wiley   +1 more source

ARHGAP11A, a member of Rho GTPase activating protein family, as a prognostic biomarker linked to DNA damage response across pan-cancer

BMC Cancer
Background The Rho GTPase-activating protein (RhoGAP) family represents a large and diverse group of proteins that act as key regulators of Rho GTPases, small GTP-binding proteins involved in cellular signaling. Tight regulation of Rho GTPase activity is
Ke Tan, Yun Wu, Jiaqi Zhang, Yuqiong Ding, Chen Cheng, Zhenyu Yan, Xuetong Wang, Liyuan Zhang   +7 more
doaj   +1 more source

HL-1 cells express an inwardly rectifying K+ current activated via muscarinic receptors comparable to that in mouse atrial myocytes [PDF]

, 2010
An inwardly rectifying K^+ current is present in atrial cardiac myocytes that is activated by acetylcholine (I_{KACh}). Physiologically, activation of the current in the SA node is important in slowing the heart rate with increased parasympathetic tone ...
A Benians, A Benians, A Benians, A Noma, AM Tolkovsky, Andrew Tinker, C Cifelli, C Marionneau, CE Ford, CL Huang, D Dobrev, D Dobrev, EN Nikolov, G Krapivinsky, I Riven, I Savelieva, J Gehrmann, JB Blumer, JL Leaney, JL Leaney, K Hu, K Wickman, L Sartiani, LC Mace, M Baruscotti, M Bechem, M Nobles, M Xia, M Yamada, MC Wellner-Kienitz, MD Drici, Muriel Nobles, N Lavine, N Voigt, O Wiser, Q Zhang, RB Robinson, S Fujita, S Peleg, SM Clancy, SM White, Sonia Sebastian, WA Boyle, WC Claycomb, Z Zuberi   +44 more
core   +2 more sources

Compensatory Interplay Between Clarin‐1 and Clarin‐2 Deafness‐Associated Proteins Governs Phenotypic Variability in Hearing

Advanced Science, EarlyView.
Functional compensation between clarin‐1 and clarin‐2 in cochlear hair cells. Hearing loss associated with CLRN1 mutations shows striking phenotypic variability; however, the underlying mechanisms remain poorly understood. This study reveals that clarin‐1 and clarin‐2 function cooperatively in cochlear hair cells to sustain mechanoelectrical ...
Maureen Wentling, Aïda Yakhlef Sanchez, Nicolas Thelen, Müge Senarisoy, Maria Hogg, Steven Condamine, Andrea Lelli, Emilia Wysocka, Pranav Patni, Sandrine Vitry, Kerem Yasin Yildizhan, Sébastien Le Gal, Sylvie Nouaille, Michael R. Bowl, Marc Thiry, Didier Dulon, Sedigheh Delmaghani, Aziz El‐Amraoui   +17 more
wiley   +1 more source

The GAPs, GEFs, and GDIs of heterotrimeric G-protein alpha subunits

International Journal of Biological Sciences, 2005
The heterotrimeric G-protein alpha subunit has long been considered a bimodal, GTP-hydrolyzing switch controlling the duration of signal transduction by seven-transmembrane domain (7TM) cell-surface receptors.
doaj