Results 111 to 120 of about 104,548 (291)
Advanced Science, EarlyView.Overcoming platinum resistance in high‐grade serous ovarian cancer (HGSOC) is critical for improving outcomes. This study identifies lncRNA CATED, elevated in platinum‐resistant small extracellular vesicles (sEVs) and tumors, which drives cisplatin resistance by enhancing DHX36 SUMOylation, boosting RAP1A translation, and activating MAPK signaling ...
Yi Liu +7 more
wiley +1 more source
Optimal regulation of protein degradation to schedule cellular events with precision [PDF]
, 2015 An important occurrence in many cellular contexts is the crossing of a prescribed threshold by a regulatory protein. The timing of such events is stochastic as a consequence of the innate randomness in gene expression. A question of interest is to understand how gene expression is regulated to achieve precision in event timing.
arxiv +1 more source
Animal Models and Experimental Medicine, EarlyView.Schematic diagram of the mechanism of DEK regulating RhoA activation Ezrin. Upon house dust mite (HDM) stimulation, HDM‐specific immunoglobulin E (IgE) and inflammatory factors such as interleukin 4 (IL‐4), IL‐5, IL‐13, and eosinophils increased in the nasal mucosa.
Longzhu Dai +8 more
wiley +1 more source
Stochastic single-gene auto-regulation [PDF]
, 2011 A detailed stochastic model of single-gene auto-regulation is established and its solutions are explored when mRNA dynamics is fast compared with protein dynamics and in the opposite regime. The model includes all the sources of randomness that are intrinsic to the auto-regulation process and it considers both transcriptional and post transcriptional ...
arxiv +1 more source
Regulation of phospholipase C-delta by GTP-binding proteins-rhoA as an inhibitory modulator
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 1998 The regulation of Phospholipase C (PLC)delta activity remains obscure. These studies show that PLCdelta1 activity is significantly enhanced by both guanosine thiotriphosphate (GTPgammaS) and Clostridium botulinum exoenzyme C3 (C3) but not by aluminium fluoride.
Alun D. Hughes +3 more
openaire +3 more sources
Signal Recognition Particle (SRP) and SRP Receptor: A New Paradigm for Multistate Regulatory GTPases [PDF]
, 2009 The GTP-binding proteins or GTPases comprise a superfamily of proteins that provide molecular switches in numerous cellular processes. The “GTPase switch” paradigm, in which a GTPase acts as a bimodal switch that is turned “on” and “off” by external ...
Schmid, Sandra L. +2 more
core +2 more sources
Curvature-sensing and generation by membrane proteins: a review [PDF]
Soft Matter 21, 3922-3940 (2025)Membrane proteins are crucial in regulating biomembrane shapes and controlling the dynamic changes in membrane morphology during essential cellular processes. These proteins can localize to regions with their preferred curvatures (curvature sensing) and induce localized membrane curvature.
arxiv +1 more source
Small GTP-binding protein PdRanBP regulates vascular tissue development in poplar
BMC Genetics, 2016 Previous research has demonstrated that ectopic expression of Ran-binding protein (RanBP) in Arabidopsis results in more axillary buds and reduced apical dominance compared to WT plants. However, the function of RanBP in poplar, which has very typical secondary growth, remains unclear.
Shaofeng Li +8 more
openaire +3 more sources
Omnipresent Maxwell’s demons orchestrate information management in living cells [PDF]
, 2019 The development of synthetic biology calls for accurate understanding of the critical functions that allow construction and operation of a living cell.
Danchin, Antoine +1 more
core
Formation and dimerization of the phosphodiesterase active site of the Pseudomonas aeruginosa MorA, a bi-functional c-di-GMP regulator [PDF]
, 2014 Diguanylate cyclases (DGC) and phosphodiesterases (PDE) respectively synthesise and hydrolyse the secondary messenger cyclic dimeric GMP (c-di-GMP), and both activities are often found in a single protein.
Keevil, Charles William +5 more
core +1 more source