Results 121 to 130 of about 149,249 (343)

Structure of the Rho Family GTP-Binding Protein Cdc42 in Complex with the Multifunctional Regulator RhoGDI [PDF]

, 2000
Gregory R. Hoffman, Nicolas Nassar, Richard A. Cerione   +2 more
openalex   +1 more source

κB‐Ras proteins are fast‐exchanging GTPases and function via nucleotide‐independent binding of Ral GTPase‐activating protein complexes

FEBS Letters
κB‐Ras (NF‐κB inhibitor‐interacting Ras‐like protein) GTPases are small Ras‐like GTPases but harbor interesting differences in important sequence motifs.
René Rasche, L. H. Apken, Esther Michalke, Daniel Kümmel, Andrea Oeckinghaus   +4 more
semanticscholar   +1 more source

The Long Noncoding RNA ΒFaar Promotes White Adipose Tissue Browning and Prevents Diet‐Induced Obesity

Advanced Science, EarlyView.
βFaar selectively targets and inhibits the GTPase activity of the RAB18 protein, thereby reducing LD volume. Conversely, βFaar promotes nuclear translocation of the transcription factor IRF4 in inguinal white adipose tissue (iWAT), facilitating the browning of white adipose tissue and attenuating body fat accumulation.
Yue Yang, Bin Huang, Baixue Sha, Danni Gao, Yimeng Qin, Ziyi Li, Xi Chen, Yinuo Jin, Yi Pan, Yanfeng Zhang, Yumeng Shen, Yu Liu, Liang Jin, Fangfang Zhang   +13 more
wiley   +1 more source

The GTP binding proteins Gem and Rad are negative regulators of the Rho–Rho kinase pathway [PDF]

, 2002
Yvona Ward, Seow-Fong Yap, Ravichandran Veerasamy, Fumio Matsumura, Masaaki Ito, Beth Spinelli, Kathleen Kelly   +6 more
openalex   +1 more source

Inhibition of AMPKα Pathway by Podocyte GOLM1 Exacerbates Diabetic Nephrology in Mice

Advanced Science, EarlyView.
Podocyte Golgi membrane protein 1 interacts with epidermal growth factor receptor to inhibit peroxisome proliferator activated receptor γ, and then inactivates adenosine monophosphate activated protein kinase α pathway, which facilitates diabetes‐related inflammation, oxidative damage, apoptosis, and renal dysfunction.
Peng Xu, Kaiqiang Li, Huasong Liu, Aibo Xu, Zhewei Zhang, Yimin Yang, Xiaobo Lai, Ke Hao, Kui Fang, Zeyu Lai, Xiping Ou, Yuqun Cai, Zhen Wang, Keda Lu, Wanli Jiang   +14 more
wiley   +1 more source

The RGK family of GTP-binding proteins: Regulators of voltage-dependent calcium channels and cytoskeleton remodeling [PDF]

, 2007
Robert N. Correll, Chunyan Pang, Dana M. Niedowicz, Brian S. Finlin, Douglas Andres   +4 more
openalex   +1 more source

Gigaxonin Potentiates Antiviral Innate Immune Responses by Targeting cGAS and TREX1

Advanced Science, EarlyView.
TREX1 antagonizes DNA sensor cGAS by degrading cytosolic DNA. This work identifies gigaxonin as a molecular switch that coordinates DNA sensing and clearance pathways to amplify antiviral responses. Under the steady state, gigaxonin maintains cellular homeostasis by mediating TREX1 ubiquitination and proteasomal degradation. During DNA virus infection,
Ben‐Zhe Ji, Jie Wang, Yi Tu, Shan Zhang, Yong‐Sheng Wei, Yan He, Bin Zhang, Qing‐Qing Zhao, Hao‐Min Hu, Yu Liu   +9 more
wiley   +1 more source

Novel Evolutionarily Conserved Oncogene COA4 is Driven by KRAS Mutant and Promotes Cancer Metastasis Through Dual Mitochondrial Metabolism‐Dependent and ‐Independent Mechanisms

Advanced Science, EarlyView.
In KRAS‐mutant tumors, KRAS transcriptionally upregulates COA4 via the PI3K/AKT/E2F1 axis, promoting metastasis. Mechanistically, COA4 enhances tumor cell migration through dual pathways: within mitochondria, it boosts oxidative phosphorylation; in the cytoplasm, it binds and activates CDC42 to stimulate pseudopodia formation.
Xingzhao Ji, Weiying Zhang, Fuyuan Xue, Jiazhen Zeng, Qinghua Zhao, Xiaoming Sun, Jian Sun, Heng Zhou, Quanlin Xu, Guoyuan Ma, Shengnan Sun, Ying Wang, Qian Mu, Yi Liu, Qiang Wan   +14 more
wiley   +1 more source

Involvement of a Small GTP-binding Protein (G Protein) Regulator, Small G Protein GDP Dissociation Stimulator, in Antiapoptotic Cell Survival Signaling [PDF]

, 2000
Ayumi Takakura, Jun Miyoshi, Hiroyoshi Ishizaki, Miki Tanaka, Atsushi Togawa, Yasuko Nishizawa, Hisahiro Yoshida, Shin‐Ichi Nishikawa, Yoshimi Takai   +8 more
openalex   +1 more source

The small GTP-binding protein TaRop10 interacts with TaTrxh9 and functions as a negative regulator of wheat resistance against the stripe rust

, 2021
Beibei Shi, Juan Wang, Haifeng Gao, Qi‐Chao Yang, Yang Wang, Brad Day, Qing Ma   +6 more
openalex   +2 more sources