Results 121 to 130 of about 104,548 (291)

Simvastatin overcomes the pPCK1‐pLDHA‐SPRINGlac axis‐mediated ferroptosis and chemo‐immunotherapy resistance in AKT‐hyperactivated intrahepatic cholangiocarcinoma

Cancer Communications, EarlyView.
Abstract Background Intrahepatic cholangiocarcinoma (ICC) is a challenging cancer with an increasing incidence. The Phase III TOPAZ‐1/KEYNOTE‐966 study demonstrated chemo‐immunotherapy (CIT) as a significant advancement, potentially replacing traditional chemotherapy for advanced biliary tract cancer.
Jinghan Zhu, Yixiao Xiong, Yuxin Zhang, Huifang Liang, Kun Cheng, Yuanxiang Lu, Guangzhen Cai, Yang Wu, Yunhui Fan, Xiaoping Chen, Hong Zhu, Zeyang Ding, Wanguang Zhang   +12 more
wiley   +1 more source

Coping with loss: cell adaptation to cytoskeleton disruption [PDF]

, 2016
Unravelling the role of cytoskeleton regulators may be complicated by adaptations to experimental manipulations. In this issue of Developmental Cell, Cerikan et al.
McGarry, David J., Olson, Michael F.
core   +1 more source

Methods for Controlling Small GTPase Activity

ChemBioChem, EarlyView.
This concept highlights recent and emerging methods for controlling small GTPase activity, encompassing both small‐molecule‐based approaches and protein engineering strategies. The use of these approaches to advance the understanding of small GTPase function, current limitations, and future outlook is discussed.
Benjamin Faulkner, Yuchen He, Daniel Sitrin, Cliff I. Stains   +3 more
wiley   +1 more source

Chromenone derivatives as CRM1 Inhibitors for Targeting Glioblastoma

ChemBioChem, Accepted Article.
Glioblastoma (GBM) is one of the most aggressive and deadly cancers. Due to the complexity and redundancy within signaling networks in GBM, targeted inhibitors of specific pathways have shown only limited success. The nuclear export receptor Chromosome Region Maintenance 1 (CRM1) has recently emerged as a promising therapeutic target, as its inhibition
Wolfgang Link, Salvatore Princiotto, Lucía Jiménez, Lucía Domínguez, João G. N. Sequeira, Cristiana Mourato, Alba Orea-Soufi, Bruno Santos, Sabrina Dallavalle, Miguel Machuqueiro, Bibiana I. Ferreira   +10 more
wiley   +1 more source

Identification of Human Proteins vulnerable to multiple Organisms and their disease associations [PDF]

arXiv, 2016
While most studies emphasize on certain aspects of Pathogen-Host Interactions (PHI), such as the preferential attachment of bacteria or virus to its human receptor homolog, studies have attempted to methodically classify interactions among pathogenic proteins and their host proteins.
arxiv  

14-3-3 Proteins Interact with a Hybrid Prenyl-Phosphorylation Motif to Inhibit G Proteins [PDF]

, 2013
Signaling through G proteins normally involves conformational switching between GTP- and GDP-bound states. Several Rho GTPases are also regulated by RhoGDI binding and sequestering in the cytosol.
Afonine, Ahearn, Andrew Purkiss, Andrew J. Thompson, Anne J. Ridley, Bokoch, Bonnefoy-Bérard, Boureux, Brad McColl, Chandra, Corey, Dalal, Emsley, Forget, Foster, Ganka Bineva, Guasch, Hancock, Hidalgo-Carcedo, Hoffman, Hogan, Hu, Ismail, Kostelecky, Lebedev, Madigan, McCoy, Michaelson, Morrison, Muslin, Nancy, Neil Q. McDonald, Nicola O’Reilly, Nicolas Reymond, Nishikawa, Nobes, Obsil, Ottmann, O’Reilly, Pacary, Pearce, Peter J. Parker, Pflugrath, Philippe Riou, Quilliam, Riento, Riento, Riou, Ritu Garg, Roberts, Robert J. Cain, Roger George, Svend Kjær, Thorson, Vagin, van Hennik, Wennerberg, Williamson, Yaffe   +58 more
core   +3 more sources

Selective [9‐15N] Guanosine for Nuclear Magnetic Resonance Studies of Large Ribonucleic Acids

ChemBioChem, EarlyView.
The small chemical shift anisotropy of nitrogen‐15 at the 9‐position in guanine (15N9‐G) leads to long T2 values and narrow NMR lines, particularly attractive to probe structure and dynamics of large (>200 nucleotide) ribonucleic acids (RNAs). RNAs regulate various cellular processes using malleable 3D structures, and understanding the factors that ...
Solomon K. Attionu, Rita Dill, Michael F. Summers, David A. Case, Jan Marchant, Theodore K. Dayie   +5 more
wiley   +1 more source

The importance of the GTP‐binding protein tissue transglutaminase in the regulation of cell cycle progression

FEBS Letters, 1995
Tissue transglutaminase (tTgase) is a GTP‐binding Ca2+‐dependent enzyme which catalyses the post‐translational modification of proteins via ϵ(γ‐glutamyl) lysine bridges. Recent evidence suggests that the GTP‐binding activity of tTgase may be important in intracellular signalling thus explaining some of the diverse suggested roles for the enzyme. In the
MIAN S, EL ALAOUI S, LAWRY J, GENTILE, Vittorio, DAVIES PJ, GRIFFIN M.   +5 more
openaire   +4 more sources

The coordination of cell growth during fission yeast mating requires Ras1-GTP hydrolysis [PDF]

, 2013
The spatial and temporal control of polarity is fundamental to the survival of all organisms. Cells define their polarity using highly conserved mechanisms that frequently rely upon the action of small GTPases, such as Ras and Cdc42.
A Merla, B Onken, C Banning, C Vanni, Cathryn Weston, DA Hughes, EC Chang, FD Kelly, FO Bendezú, FS Wouters, G Ladds, G Ladds, G Ladds, G Ladds, G Ladds, G Ladds, Graham Ladds, H Murakoshi, H Tatebe, H Tu, I Tratner, J Davey, J Davey, J Davey, J Marks, JL Brown, JM Mitchison, Juan Mata, K Hirota, K Kitamura, K Maundrell, K Nakano, K Scheffzek, M Das, M Didmon, M Hachet-Haas, M Hamilton, M Malumbres, M Toya, MD Abramoff, Michael Bond, O Nielsen, P Fantes, P García, P Gideon, P Papadaki, PM Coll, R Egel, S Ottilie, S Sazer, SA Rincón, SR Sprang, T Masuda, TT Maeda, V Jung, V Snell, Wayne Croft, Y Imai, Y Imai   +58 more
core   +3 more sources

Characterization of DnaB‐DnaG Interaction in M. tuberculosis using a SAXS‐Based Dissociation Assay

ChemBioChem, Accepted Article.
We studied the complex interactions between helicase and primase, two key components of the replisome involved in DNA replication in Mycobacterium tuberculosis. Utilizing purified, complementary domains of these proteins, we employed a surface plasmon resonance (SPR) analysis and a cross‐linking assay to characterize their binding dynamics.
Barak Akabayov, Adi Dayan, Stefan Ilic
wiley   +1 more source