MedComm – Oncology, Volume 5, Issue 3, September 2026.Ferroptosis is governed by the balance between reactive oxygen species (ROS)‐driven lipid peroxidation and a multi‐tiered antioxidant network. ROS sources include mitochondrial electron transport chain, voltage‐dependent anion channels, NADPH oxidases, and endoplasmic reticulum‐resident oxidoreductases, while antioxidant defenses span the primary GSH ...
Deepak K +5 more
wiley +1 more source
OPA1 as a Cancer Target: Molecular Mechanisms, Structural Insights, and Strategies for Drug Development. [PDF]
Antioxidants (Basel)Curcio A +7 more
europepmc +1 more source
The atomistic Mechanism Underlying Regulation of the GPA1 G Protein Signaling Pathway Mediated by Abscisic Acid (ABA) Phytohormone Binding to the GCR1 Plant G Protein Coupled Receptor. [PDF]
J Chem Inf ModelHernández PM +4 more
europepmc +1 more source
Animal Genetics, Volume 57, Issue 4, August 2026.ABSTRACT This study aimed to investigate how maternal feed restriction at different gestational stages alters the expression of novel long non‐coding RNAs (lncRNAs) in the skeletal muscle of goat offspring. LncRNAs are emerging as important regulators of biological processes, including myogenesis, yet their role in fetal programming remains largely ...
Maria M. M. Muniz +8 more
wiley +1 more source
Overexpression generates aberrant distribution of endocytic regulators - the case of the Rab11/LAMP1 compartment. [PDF]
PLoS OneHornfeck S, Trofimenko E, Widmann C.
europepmc +1 more source
A Modular Nucleoside Kinase Cascade for the Synthesis of Ribonucleoside Triphosphates
Biotechnology and Bioengineering, Volume 123, Issue 8, Page 2180-2191, August 2026.Damm et al. report standardized enzymatic cascades for production of all canonical nucleoside triphosphates from the corresponding nucleosides, using kinase‐catalyzed phosphorylation from acetyl phosphate. Reactions afforded ∼ 100 mM product in near‐quantitative conversion.
Oliver T. Damm +3 more
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PI3K Regulates Wild-type RAS Signaling to Confer Resistance to KRAS Inhibition. [PDF]
Cancer ResGe X +8 more
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Insights Into the Biological Mechanisms and Multifunctional Health Benefits of Morelloflavone
eFood, Volume 7, Issue 4, August 2026.Morelloflavone (MF), a biflavonoid from Garcinia and related species, exhibits broad human health benefits through antioxidant, anti‐inflammatory, anticancer, and metabolic regulatory effects. This review highlights its molecular mechanisms, biosynthesis, and emerging roles in chronic disease prevention, emphasizing systems biology and machine learning
Yi Liu +4 more
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Y-box binding protein-1 at the crossroads of DNA damage response and tumor immune evasion. [PDF]
JNCI Cancer SpectrToulany M, Sodji QH.
europepmc +1 more source
Astrocytic mGluR5 Regulation of Synaptic Transmission is Activity‐Dependent in Adult Rats
Glia, Volume 74, Issue 8, August 2026.In adulthood, astrocytic mGluR5 increases synaptic efficacy through presynaptic A2ARs. This occurs when a small number of synapses are activated simultaneously. This pathway is abolished when numerous synapses are recruited. ABSTRACT Data accumulated over the last two decades have demonstrated that astrocytes play key roles in the regulation of ...
Sarah Mountadem +18 more
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