Results 91 to 100 of about 12,400 (144)
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Current Opinion in Structural Biology, 1991
Abstract There has been much progress this year in characterizing the complex series of post-translational modifications important for GTP-binding protein function. In addition, the long-awaited molecular characterization of a G protein that regulates phospholipase C activity has been reported.
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Abstract There has been much progress this year in characterizing the complex series of post-translational modifications important for GTP-binding protein function. In addition, the long-awaited molecular characterization of a G protein that regulates phospholipase C activity has been reported.
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The International Journal of Biochemistry & Cell Biology, 1997
RhoA, RhoB and RhoC are three closely related proteins, and are members of the Ras super-family of small GTP-binding proteins. They bind and hydrolyse GTP, and are active in the GTP-bound form. Their activity in cells is regulated by exchange factors, GTPase activating proteins and guanine nucleotide dissociation inhibitors.
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RhoA, RhoB and RhoC are three closely related proteins, and are members of the Ras super-family of small GTP-binding proteins. They bind and hydrolyse GTP, and are active in the GTP-bound form. Their activity in cells is regulated by exchange factors, GTPase activating proteins and guanine nucleotide dissociation inhibitors.
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GTP-binding proteins in a cyanobacterium Anabaenacylindrica
Biochemical and Biophysical Research Communications, 1988GTP-binding proteins were detected in a crude extract containing membrane components of Anabaena cylindrica. The crude extract was treated with 1% Lubrol PX and was fractionated by gel filtration. The binding of [35S]GTP gamma S to GTP-binding proteins was prevented in the presence of 0.1 mM GTP and in the presence of 0.1 mM ATP. Six fractions of these
Kazuhiko Furukawa +2 more
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Purification of a GTP-Binding Protein Localized in Mitochondria1
The Journal of Biochemistry, 1993A particulate fraction consisting of heavy organelles such as nuclei and mitochondria was prepared from Ehrlich ascites tumor cells. From this fraction we have purified a GTP-binding protein with a molecular mass of 33 kDa (MTG33) by guanidine hydrochloride extraction followed by four steps of column chromatography. The Kd value of MTG33 for GTP was 17
Shizu Takeda +4 more
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Small GTP-binding proteins in Plasmodium falciparum
Biology of the Cell, 1996Summary— During its erythrocytic life cycle Plasmodium falciparum exchanges compounds with host cells through phagocytosis and exocytosis. In eucaryotic cells, small GTP‐binding proteins of the Ras superfamily appear to be involved in different steps of membrane trafficking and in intracellular signals.
Birgitta Olofsson +4 more
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GTP-binding proteins in intracellular transport
Trends in Cell Biology, 1992One of the most exciting recent discoveries in the area of intracellular protein transport is the finding that many organelles involved in exocytic and endocytic membrane traffic have one or more Ras-like GTP-binding proteins on their cytoplasmic face that are specific for each membranous compartment.
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GTP-binding Proteins and Signal Transduction
2002Being metabolic regulators, nucleotides play many other roles rather than just providing the alphabets of the genetic code. The pyrimidine bases act as identifiers for metabolites. Purine nucleotides play their main regulatory roles in association with proteins, not metabolites.
Peter E.R. Tatham +2 more
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The Role of GTP-Binding Proteins in Platelet Activation
Thrombosis and Haemostasis, 1991SummaryPlatelet activation begins with the binding of an agonist to the cell surface and culminates in the events of platelet aggregation, secretion and clot formation. Recent studies have identified two large families of GTP-binding proteins in platelets that are thought to participate in the events of platelet activation. The first of these are the G
David R. Manning, Lawrence F. Brass
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Identification and isoprenylation of plant GTP-binding proteins
Plant Molecular Biology, 1996To identify isoprenylated plant GTP-binding proteins, Arabidopsis thaliana and Nicotiana tabacum cDNA expression libraries were screened for cDNA-encoded proteins capable of binding [32P]GTP in vitro. ATGB2, an Arabidopsis homologue of the GTP-binding protein Rab2, was found to bind GTP in vitro and to be a substrate for a geranylgeranyl:protein ...
Stephen K. Randall +2 more
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GTP Binding Proteins in Platelets
1999Cells are constantly engulfed in an environment of electrical and chemical stimuli. Specific receptors enable cells to differentiate among the stimuli and relay a specific message that leads to a defined cellular response. The process that translates the stimulus-receptor interaction into an intracellular chemical message is termed signal transduction.
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