Results 91 to 100 of about 1,111,922 (385)

Roles of Heterotrimeric GTP-Binding Proteins in the Progression of Heart Failure

Journal of Pharmacological Sciences, 2011
.: Heart failure is a major cause of death in developed countries, and the development of an epoch-making cure is desired from the viewpoint for improving the quality of life and reducing the medical cost of the patient.
Motohiro Nishida
doaj   +1 more source

Expression Analysis of the Small GTP-Binding Protein Rac in Pterygium

Türk Oftalmoloji Dergisi, 2023
Objectives: To determine the roles of small GTP-binding proteins Rac1, Rac2, and Rac3 expression in pterygial tissue and to compare these expressions with normal conjunctival tissue.
Ahmet Saracaloğlu, Şeniz Demiryürek, Kıvanç Güngör, Betül Düzen, Ömer Eronat, Ebru Temiz, Abdullah Tuncay Demiryürek   +6 more
doaj   +1 more source

Pigment Epithelium‐Derived Factor Deficiency Impairs Hippocampal Glutamate Homeostasis and Cognitive Function by Downregulating Astrocytic GLT‐1

Advanced Science, EarlyView.
The chronic glutamate‐induced excitotoxicity hypothesis has profoundly informed the therapeutic strategies employed in Alzheimer’s disease (AD). This study shows pigment epithelium‐derived factor (PEDF) regulates astrocytic glutamate transporter‐1 (GLT‐1)‐mediated glutamate homeostasis and cognition. Reduced PEDF correlates with lower Mini‐Mental State
Jin‐Hui Shi, Qi‐Long Tang, Jin‐Hong Wang, Yan‐Lan Long, Sai‐Feng Zhao, Zhen Zhao, Wan‐Ting Xie, Zi‐Ming Li, Hao‐Ming Lu, Tian‐Xiao Gao, Zhen‐Zhen Fang, Ti Zhou, Bo‐Xing Li, Xia Yang, Guo‐Quan Gao, Wei‐Wei Qi   +15 more
wiley   +1 more source

Ectopic A-lattice seams destabilize microtubules [PDF]

, 2014
Natural microtubules typically include one A-lattice seam within an otherwise helically symmetric B-lattice tube. It is currently unclear how A-lattice seams influence microtubule dynamic instability.
A des Georges, A Desai, A Dimitrov, A Grafmuller, AA Hyman, B Vitre, D Chretien, D Chretien, D Chretien, D Chretien, D Panda, D Sept, DJ Odde, DN Drechsel, DP Dias, DR Drummond, E Nogales, EM Mandelkow, EM Mandelkow, FM Coquelle, G Brouhard, G Margolin, H Bowne-Anderson, H Sui, IM Crevel, JG Cueva, JL Hoog, JR McIntosh, JR Simon, JS Kaye, KE Busch, L Amos, L Sandblad, LG Tilney, LM Rice, M Braun, M Caplow, M Caplow, M Katsuki, M Katsuki, M Kikkawa, MK Gardner, MK Gardner, N Galjart, P Bieling, R Dallai, RA Walker, RA Walker, SP Maurer, SP Maurer, T Mitchison, T Mitchison, Y Komarova, YH Song, ZC Zhu   +54 more
core   +1 more source

Post‐Translational Modified Neoantigens in Autoimmune Diseases: Challenges of Immune Tolerance

Advanced Science, EarlyView.
Autoimmune diseases have a high incidence and disability rate. The pathogenesis of autoimmune diseases involves the interaction among genetic factors, environmental factors, and immune disorders. The post‐translational modified neoantigens are the key nodal of these three factors. And these post‐translational modified neoantigens, after being presented
Yue Zhai, Kefei Wu, Qi Lin, Zhenzhen Cao, Yankun Jia, Ping Zhu   +5 more
wiley   +1 more source

Nucleotide based covalent inhibitors of KRas can only be efficient in vivo if they bind reversibly with GTP-like affinity

Scientific Reports, 2017
Simple reversible competitive inhibition of nucleotide binding of GTP to Ras family GTPases has long been recognized as an unlikely approach to manipulating the activity of such proteins for experimental or therapeutic purposes.
Matthias P. Müller, Sadasivam Jeganathan, Angelika Heidrich, Jeremy Campos, Roger S. Goody   +4 more
doaj   +1 more source

Structural basis of human PDZD8–Rab7 interaction for the ER-late endosome tethering

Scientific Reports, 2021
The membrane contact sites (MCSs) between the ER and late endosomes (LEs) are essential for the regulation of endosomal protein sorting, dynamics, and motility.
Haider Khan, Lin Chen, Lingchen Tan, Young Jun Im   +3 more
doaj   +1 more source

Structural basis of mitochondrial receptor binding and constriction by DRP1. [PDF]

, 2018
Mitochondrial inheritance, genome maintenance and metabolic adaptation depend on organelle fission by dynamin-related protein 1 (DRP1) and its mitochondrial receptors. DRP1 receptors include the paralogues mitochondrial dynamics proteins of 49 and 51 kDa
Agard, David A, Frost, Adam, Kalia, Raghav, Shaw, Janet M, Thomas, Paul V, Wang, Ray Yu-Ruei, Yusuf, Ali   +6 more
core   +1 more source

Activation of Kir4.1 Channels by 2‐D08 Promotes Myelin Repair in Multiple Sclerosis

Advanced Science, EarlyView.
Multiple sclerosis causes myelin loss and neurological dysfunction. This study shows that 2‐D08, a small molecule targeting Kir4.1 channels, promotes OPCs differentiation via FYN tyrosine kinase phosphorylation and the FYN/MYRF pathway. It significantly improves myelin repair and motor deficits in EAE mice and marmosets, highlighting its potential as a
Mingdong Liu, Shengyu Jin, Xin Fu, Chong Xie, Yi Chen, Liangtang Chang, Yongheng Fan, Donghua He, Xiaoqi Hong, Xi Shen, Xiaoli Zheng, Qiyue Wang, Dao Shi, Fangyuan Li, Daishun Ling, Yangtai Guan, Neng Gong, Xiaoping Tong   +17 more
wiley   +1 more source

Alteraciones en el reclutamiento y activación de proteínas Rab durante la infección micobacteriana

Biomédica: revista del Instituto Nacional de Salud, 2010
En el fagosoma, Mycobacterium spp. altera la activación y reclutamiento de diferentes proteínas "del gen Ras de cerebro de rata", comúnmente conocidas como Rab.
Diana Castaño, Mauricio Rojas
doaj   +1 more source