Results 111 to 120 of about 232,963 (342)

Characterization of Novel Derivatives of MBQ-167, an inhibitor of the GTP-binding proteins Rac/Cdc42. [PDF]

Cancer Res Commun, 2022
Medina JI, Cruz-Collazo A, Del Mar Maldonado M, Gascot TM, Borrero-Garcia LD, Cooke M, Kazanietz MG, O'Farril EH, Vlaar CP, Dharmawardhane S.   +9 more
europepmc   +1 more source

The gateway to chloroplast: re-defining the function of chloroplast receptor proteins [PDF]

, 2012
Chloroplast biogenesis often requires a tight orchestration between gene expression (both plastidial and nuclear) and translocation of similar to 3000 nuclear-encoded proteins into the organelle.
Bölter, Bettina, Chang, Wai-Ling, Soll, Jürgen   +2 more
core   +1 more source

cGAS Inhibits ALDH2 to Suppress Lipid Droplet Function and Regulate MASLD Progression

Advanced Science, EarlyView.
cGAS is a cytosolic DNA sensor known for innate immune defense. cGAS binds and suppresses ALDH2 are showed, limiting acetyl‐CoA production. cGAS loss activates ALDH2, promoting histone acetylation, lipogenesis, and lipid droplets accumulation. cGas‐/‐ mice on a high‐fat diet show signs of worsened MASLD.
Ying Wang, Yu Deng, Jianfeng Chen, Quentin Hahn, David S. Umbaugh, Zhigang Zhang, Yanqiong Zhang, Sarah E. Rowe, Lupeng Li, Laura E. Herring, Brian P. Conlon, Edward A. Miao, Blossom Damania, Anna Mae Diehl, Pengda Liu   +14 more
wiley   +1 more source

A distinct class of GTP-binding proteins mediates chloroplast protein import in Rhodophyta. [PDF]

Proc Natl Acad Sci U S A, 2022
Baek S, Imamura S, Higa T, Nakai Y, Tanaka K, Nakai M.   +5 more
europepmc   +1 more source

Regulation of TORC2 function and localization by Rab5 GTPases in Saccharomyces cerevisiae. [PDF]

, 2019
The evolutionarily conserved Target of Rapamycin (TOR) complex-2 (TORC2) is an essential regulator of plasma membrane homeostasis in budding yeast (Saccharomyces cerevisiae).
Locke, Melissa N, Thorner, Jeremy
core   +1 more source

A Rab10:RalA G protein cascade regulates insulin-stimulated glucose uptake in adipocytes. [PDF]

, 2014
Insulin-stimulated glucose uptake in fat and muscle is mediated by the major facilitative glucose transporter Glut4. Insulin controls the trafficking of Glut4 to the plasma membrane via regulation of a series of small G proteins, including RalA and Rab10.
Chen, Xiao-Wei, Karunanithi, Sheelarani, Leto, Dara, Saltiel, Alan R, Sun, Jingxia, Uhm, Maeran, Xiong, Tingting   +6 more
core   +1 more source

ARL3 Enhances ERα Stability via USP10 Deubiquitination to Promote Endocrine Resistance and Drive Mitochondrial Metabolic Reprogramming in HR+ Breast Cancer

Advanced Science, EarlyView.
This study identifies ADP‐ribosylation factor‐like protein 3 (ARL3) as a novel chaperone that stabilizes estrogen receptor α (ERα) in breast cancer. ARL3 promotes tumor growth by recruiting USP10 to remove ubiquitin chains from ERα, preventing its degradation.
Han Li, Yang Liu, Zehao Cai, Kang Li, Shun Gao, Ailin Lan, Dan Shu, Kuan He, Xin Liu, Yang Peng, Shipeng Guo, Haochen Yu, Aishun Jin, Meiying Shen, Shengchun Liu   +14 more
wiley   +1 more source

Lactate Metabolic Reprogramming Mediated by CircRNA–LDHA Complex Facilitates Innate Immune Evasion of Liver Cancer

Advanced Science, EarlyView.
CircSMPD4 physically combines with lactate dehydrogenase A (LDHA) and reduces its acetylation level via SIRT2‐dependent deacetylation, thereby inhibiting chaperone‐mediated autophagy‐lysosome degradation of LDHA. Upregulating LDHA leads to increasing lactate production and extracellular export, which in turn suppresses natural killer cell cytotoxicity ...
Hao Shen, Boqiang Liu, Jing He, Weijun Zhao, Weiqi Li, Lingfeng Ma, Lidan Hou, Yi Wang, Chenqi Jin, Yushun Chang, Jie Lin, Jia Zhao, Binghan Jin, Yuanshi Tian, Xiujun Cai, Liang Shi, Yifan Wang   +16 more
wiley   +1 more source

Targeted Quantitative Profiling of GTP-Binding Proteins Associated with Metastasis of Melanoma Cells. [PDF]

J Proteome Res, 2021
Cai R, Bade D, Liu X, Huang M, Qi TF, Wang Y.   +5 more
europepmc   +1 more source

Reduced expression of multiple forms of the alpha subunit of the stimulatory GTP-binding protein in pseudohypoparathyroidism type Ia. [PDF]

, 1987
A Carter, C. Wayne Bardin, Rory Collins, C Simons, Patrick F. Bray, Allen M. Spiegel   +5 more
openalex   +1 more source