Hyperkeratosis of (a) the footpads and (b) the nasal planum. ABSTRACT Background Canine leishmaniosis (CanL) due to Leishmania infantum remains common, and veterinarians do not always follow scientifically sound approaches for diagnosis, treatment and prevention. Objectives To provide consensus guidelines for diagnosis and evidence‐based guidelines for
Manolis N. Saridomichelakis+9 more
wiley +1 more source
RESEARCH CHALLENGES IN STAGE III AND IV RAS-ASSOCIATED CANCERS: A Narrative Review of the Complexities and Functions of the Family of <i>RAS</i> Genes and Ras Proteins in Housekeeping and Tumorigenesis. [PDF]
McDonald RA+2 more
europepmc +1 more source
Abstract figure legend Neurotransmitter release was characterized at post‐hearing rat calyx of Held synapses, before and after pharmacologically augmenting synaptic strength, by recording unitary EPSCs, or capacitance changes in response to presynaptic step depolarizations.
Kun‐Han Lin+5 more
wiley +1 more source
NMR <sup>1</sup>H, <sup>13</sup>C, and <sup>15</sup>N resonance assignments of the oncogenic Q61R variant of human NRAS in the active, GTP-bound conformation. [PDF]
Sharma AK+7 more
europepmc +1 more source
The synaptic vesicle cluster as a controller of pre‐ and postsynaptic structure and function
Abstract figure legend The synaptic vesicle cluster acts as a master regulator of synaptic structure and function, through various involvements in processes that range from synaptic initiation to plasticity and synaptic loss. Abstract The synaptic vesicle cluster (SVC) is an essential component of chemical synapses, which provides neurotransmitter ...
Sofiia Reshetniak+35 more
wiley +1 more source
Guanylate cyclase activity in moss: revisiting the role of ERECTA-like receptors. [PDF]
Hammer K+5 more
europepmc +1 more source
Membrane trafficking of synaptic adhesion molecules
Abstract figure legend Synaptic cellular adhesion molecules are surface transmembrane receptors that have been shown to internalize via endocytosis, and possibly also recycle, in a process that has been linked to the function and the turnover of the synaptic contact site.
Cristian A. Bogaciu, Silvio O. Rizzoli
wiley +1 more source
Exploring the interaction dynamics of eukaryotic translation initiation factor 2. [PDF]
Marintchev A.
europepmc +1 more source
Abstract figure legend During development, Intersectin‐1 (Itsn1) translocates near voltage‐gated calcium channels (VGCCs) to enhance Ca2+‐dependent replenishment of readily releasable synaptic vesicles (SVs). In the presynaptic terminal, SVs undergo a cycle involving formation (step 1), docking (step 2), exocytosis (step 3), endocytosis (step 4) and ...
Yi‐Mei Yang+13 more
wiley +1 more source
Persistence of quantal synaptic vesicle recycling in virtual absence of dynamins
Abstract figure legend Figure depicts the key finding from this study. While loss of all dynamins severely debilitates synaptic vesicle retrieval following repetitive activity, retrieval and recycling of individual synaptic vesicles following spontaneous fusion or sparse stimulation are minimally affected.
Olusoji A. T. Afuwape+4 more
wiley +1 more source