Results 51 to 60 of about 2,779,262 (305)

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

Molecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez, Rafael Pérez‐Díaz, Hugo Ramos‐Solano, Marina Garrido‐Casado, Vanessa C. Talayero, Miguel Vicente‐Manzanares   +5 more
wiley   +1 more source

Tau Avoids the GTP Cap at Growing Microtubule Plus-Ends

iScience, 2020
Summary: Plus-end tracking proteins (+TIPs) associate with the growing end of microtubules and mediate important cellular functions. The majority of +TIPs are directed to the plus-end through a family of end-binding proteins (EBs), which preferentially ...
Brian T. Castle, Kristen M. McKibben, Elizabeth Rhoades, David J. Odde   +3 more
doaj   +1 more source

Mechanistic insights into the effect of phosphorylation on Ras conformational dynamics and its interactions with cell signaling proteins

Computational and Structural Biotechnology Journal, 2021
Ras undergoes interconversion between the active GTP-bound state and the inactive GDP-bound state. This GTPase cycle, which controls the activities of Ras, is accelerated by Ras GTPase-activating proteins (GAPs) and guanine nucleotide exchange factors ...
Yuanhao Wang, Dong Ji, Chaoyu Lei, Yingfei Chen, Yuran Qiu, Xinyi Li, Mingyu Li, Duan Ni, Jun Pu, Jian Zhang, Qiang Fu, Yaqin Liu, Shaoyong Lu   +12 more
doaj   +1 more source

The gateway to chloroplast: re-defining the function of chloroplast receptor proteins [PDF]

, 2012
Chloroplast biogenesis often requires a tight orchestration between gene expression (both plastidial and nuclear) and translocation of similar to 3000 nuclear-encoded proteins into the organelle.
Bölter, Bettina, Soll, Jürgen, Chang, Wai-Ling   +2 more
core   +1 more source

p190A/ARHGAP35 and p190B/ARHGAP5 proteins in endometrial cancer: a novel cancer‐relevant paralog interplay

Molecular Oncology, EarlyView.
This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault, Capucine Heraud, Mélissa Correia de Oliveira, Véronique Neaud, Valérie Valesco, Valérie Prouzet‐Mauleon, Béatrice Turcq, Jean‐William Dupuy, Anne‐Aurélie Raymond, Sabrina Croce, Frédéric Saltel, Valérie Lagrée, Violaine Moreau   +12 more
wiley   +1 more source

An HflX-type GTPase from Sulfolobus solfataricus binds to the 50S ribosomal subunit in all nucleotide-bound states [PDF]

, 2011
HflX GTPases are found in all three domains of life, Bacteria, Archaea, and Eukaryotes. HflX from Escherichia coli has been shown to bind to the 50S ribosomal subunit in a nucleotide-dependent manner and this interaction strongly stimulates its GTPase ...
Fabian Blombach, J. Van Der Oost, Daan C. Swarts, John van der Oost, Londei, P., LONDEI, Paola, Christodoulou, John, John Christodoulou, Dario Benelli, D. c. Swarts, Lisa D. Cabrita, Launay, H., BENELLI, DARIO, H. Launay, Benelli, D., L. d. Cabrita, Violeta Zorraquino, Zorraquino, V., Cabrita, L.D., V. Zorraquino, Oost, J., van der, F. Blombach, J. Christodoulou, Helene Launay, Paola Londei, van der Oost, J., Blombach, F., Swarts, D.C.   +27 more
core   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

SIÇAN BEYİN G PROTEİNLERİNİN KARAKTERİZASYONU

Cerrahpaşa Medical Journal, 2014
Background and Design.- Heterotrimeric guanine nucleotide binding protein (G proteins) play a central role in regulation of signal transmission in the cell. G proteins which are localized in the inner surface of the cell membrane consist of α-, β- and γ-
Hülya CABADAK, Beki KAN
doaj  

Septin6 and Septin7 GTP binding proteins regulate AP-3- and ESCRT-dependent multivesicular body biogenesis. [PDF]

PLoS ONE, 2014
Septins (SEPTs) form a family of GTP-binding proteins implicated in cytoskeleton and membrane organization, cell division and host/pathogen interactions. The precise function of many family members remains elusive.
Sofia Traikov, Christoph Stange, Thomas Wassmer, Perrine Paul-Gilloteaux, Jean Salamero, Graça Raposo, Bernard Hoflack   +6 more
doaj   +1 more source

Co-crystalization reveals the interaction between AtYchF1 and ppGpp

Frontiers in Molecular Biosciences, 2022
AtYchF1 is an unconventional G-protein in Arabidopsis thaliana that exhibits relaxed nucleotide-binding specificity. The bindings between AtYchF1 and biomolecules including GTP, ATP, and 26S rRNA have been reported.
Ming-Yan Cheung, Xiaorong Li, Yee-Shan Ku, Zhongzhou Chen, Hon-Ming Lam   +4 more
doaj   +1 more source