Results 31 to 40 of about 2,779,262 (305)

In silico docking of forchlorfenuron (FCF) to septins suggests that FCF interferes with GTP binding.

PLoS ONE, 2014
Septins are GTP-binding proteins that form cytoskeleton-like filaments, which are essential for many functions in eukaryotic organisms. Small molecule compounds that disrupt septin filament assembly are valuable tools for dissecting septin functions with
Dimitrios Angelis, Eva Pauline Karasmanis, Xiaobo Bai, Elias T Spiliotis   +3 more
doaj   +1 more source

The Arabidopsis ppi1 mutant is specifically defective in the expression, chloroplast import, and accumulation of photosynthetic proteins [PDF]

, 2003
The import of nucleus-encoded proteins into chloroplasts is mediated by translocon complexes in the envelope membranes. A component of the translocon in the outer envelope membrane, Toc34, is encoded in Arabidopsis by two homologous genes, atTOC33 and ...
Baldwin, Amy, Lilley, Kathryn, Leister, D., Kubis, Sybille, Kurth, Joachim, Kurth, J., Paul Dupree, Baldwin, Amy Joy, Razzaq, A., Dupree, Paul, Baldwin, A., Paul Jarvis, Sybille Kubis, Patel, R., Lilley, K., Azam Razzaq, Kubis, S., Leister, Dario, Amy Baldwin, Jarvis, Paul, Razzaq, Azam, Dario Leister, Kathryn Lilley, Jarvis, P., Dupree, P., Ramesh Patel, Joachim Kurth, Patel, Ramesh   +27 more
core   +1 more source

ARF: the most misunderstood GTPase I ever knew - why study ARF GAPs

Frontiers in Molecular Biosciences
ADP-ribosylation factors (ARFs) are GTP-binding proteins that were discovered in the early 1980s, shortly after heterotrimeric GTP-binding proteins (G proteins) and nearly simultaneously with RAS.
Rachel E. Turn, Joel Bryan Dacks, Eric M. Rosenberg, Olivier Soubias, John K. Northup, Paul A. Randazzo   +5 more
doaj   +1 more source

Autism and mild epilepsy associated with a de novo missense pathogenic variant in the GTPase effector domain of DNM1

American Journal of Medical Genetics Part C: Seminars in Medical Genetics, EarlyView., 2023
Abstract Dynamin 1 is a GTPase protein involved in synaptic vesicle fission, which facilitates the exocytosis of neurotransmitters necessary for normal signaling. Pathogenic variants in the DNM1 gene are associated with intractable epilepsy, often manifested as infantile spasms at onset, developmental delay, and a movement disorder, and are located in ...
Davide Mei, Elena Parrini, Claudia Bianchini, Maria Luisa Ricci, Renzo Guerrini   +4 more
wiley   +1 more source

GTP-Binding Proteins and Regulated Exocytosis [PDF]

Critical Reviews in Oral Biology & Medicine, 1999
Regulated exocytosis, which occurs in response to stimuli, is a two-step process involving the docking of secretory granules (SGs) at specific sites on the plasma membrane (PM), with subsequent fusion and release of granule contents. This process plays a crucial role in a number of tissues, including exocrine glands, chromaffin cells, platelets, and ...
openaire   +2 more sources

Recruitment of AP-1 clathrin adaptors to liposomal membranes [PDF]

, 2004
Protein and membrane traffic between organelles within the endocytic and exocytic pathway is mediated most prominently by coated vesicles. These vesicles are formed by the assembly of cytosolic coat proteins onto the donor membrane, which deform it into ...
Meyer, Daniel Markus
core   +1 more source

IQGAP Family Members in Yeast, Dictyostelium, and Mammalian Cells

International Journal of Cell Biology, 2012
IQGAPs are a family of scaffolding proteins with multiple domains, named for the IQ motifs and GTPase activating protein (GAP) related domains. Despite their GAP homology, IQGAP proteins act as effectors for GTP-bound GTPases of the Ras superfamily and ...
Katie B. Shannon
doaj   +1 more source

The GTP- and Phospholipid-Binding Protein TTD14 Regulates Trafficking of the TRPL Ion Channel in Drosophila Photoreceptor Cells. [PDF]

PLoS Genetics, 2015
Recycling of signaling proteins is a common phenomenon in diverse signaling pathways. In photoreceptors of Drosophila, light absorption by rhodopsin triggers a phospholipase Cβ-mediated opening of the ion channels transient receptor potential (TRP) and ...
Alexander C Cerny, André Altendorfer, Krystina Schopf, Karla Baltner, Nathalie Maag, Elisabeth Sehn, Uwe Wolfrum, Armin Huber   +7 more
doaj   +1 more source

Ectopic A-lattice seams destabilize microtubules [PDF]

, 2014
Natural microtubules typically include one A-lattice seam within an otherwise helically symmetric B-lattice tube. It is currently unclear how A-lattice seams influence microtubule dynamic instability.
Cross, R. A., Katsuki, Miho, Drummond, Douglas R.   +2 more
core   +1 more source

Divergent Mechanisms Activating RAS and Small GTPases Through Post-translational Modification

Frontiers in Molecular Biosciences, 2021
RAS is a founding member of the RAS superfamily of GTPases. These small 21 kDa proteins function as molecular switches to initialize signaling cascades involved in various cellular processes, including gene expression, cell growth, and differentiation ...
Natsuki Osaka, Yoshihisa Hirota, Yoshihisa Hirota, Doshun Ito, Doshun Ito, Yoshiki Ikeda, Ryo Kamata, Yuki Fujii, Yuki Fujii, Venkat R. Chirasani, Sharon L. Campbell, Koh Takeuchi, Toshiya Senda, Toshiya Senda, Toshiya Senda, Atsuo T. Sasaki, Atsuo T. Sasaki, Atsuo T. Sasaki, Atsuo T. Sasaki   +18 more
doaj   +1 more source