Results 11 to 20 of about 231,218 (308)
Turning Platelets Off and On: Role of RhoGAPs and RhoGEFs in Platelet Activity
Frontiers in Cardiovascular Medicine, 2022 Platelet cytoskeletal reorganisation is a critical component of platelet activation and thrombus formation in haemostasis. The Rho GTPases RhoA, Rac1 and Cdc42 are the primary drivers in the dynamic reorganisation process, leading to the development of ...
Shane P. Comer, Shane P. Comer
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Purification and characterization of human H-RAS proteins expressed in Escherichia coli [PDF]
, 1985 The full-length normal and T24 mutant human H-ras proteins and two truncated derivatives of the T24 mutant were expressed efficiently in Escherichia coli. The proteins accumulated to 1 to 5% of total cellular protein, and each was specifically recognized
Gross, M. +7 more
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GTP Binding Assays in Arabidopsis thaliana
Bio-Protocol, 2013 Signaling through G proteins constitutes an ancient mechanism that functions in the transduction of extracellular signals into intracellular responses. Activation of a proper receptor by a stimuli leads to an exchange of GDP for GTP, the activation of G ...
Ana Fox, Maria Mazzella
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Yeast Irc6p is a novel type of conserved clathrin coat accessory factor related to small G proteins. [PDF]
, 2012 Clathrin coat accessory proteins play key roles in transport mediated by clathrin-coated vesicles. Yeast Irc6p and the related mammalian p34 are putative clathrin accessory proteins that interact with clathrin adaptor complexes.
Cascio, Duilio +5 more
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GTP-binding-defective ARL4D alters mitochondrial morphology and membrane potential. [PDF]
PLoS ONE, 2012 ARL4D, ARL4A, and ARL4C are closely related members of the ADP-ribosylation factor/ARF-like protein (ARF/ARL) family of GTPases. All three ARL4 proteins contain nuclear localization signals (NLSs) at their C-termini and are primarily found at the plasma ...
Chun-Chun Li +7 more
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Involvement of a small GTP binding protein in HIV-1 release
Retrovirology, 2005 Background There is evidence suggesting that actin binding to HIV-1 encoded proteins, or even actin dynamics themselves, might play a key role in virus budding and/or release from the infected cell.
Gluschankof Pablo +2 more
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LRRK2 kinase activity is dependent on LRRK2 GTP binding capacity but independent of LRRK2 GTP binding. [PDF]
PLoS ONE, 2011 Leucine rich repeat kinase 2 (LRRK2) is a Parkinson's disease (PD) gene that encodes a large multidomain protein including both a GTPase and a kinase domain.
Jean-Marc Taymans +7 more
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eLife, 2023 Guanylate binding proteins (GBPs) are soluble dynamin-like proteins that undergo a conformational transition for GTP-controlled oligomerization and disrupt membranes of intracellular parasites to exert their function as part of the innate immune system ...
Thomas-O Peulen +15 more
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Nucleotide binding switches the information flow in ras GTPases.
PLoS Computational Biology, 2011 The Ras superfamily comprises many guanine nucleotide-binding proteins (G proteins) that are essential to intracellular signal transduction. The guanine nucleotide-dependent intrinsic flexibility patterns of five G proteins were investigated in atomic ...
Francesco Raimondi +3 more
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The chloroplast import receptor Toc34 functions as preprotein-regulated GTPase [PDF]
, 2002 Toc34 is a protein of the chloroplast outer envelope membrane that acts as receptor for preproteins containing a transit sequence. The recognition of preproteins by Toc34 is regulated by GTP binding and phosphorylation.
Hörth, P. +5 more
core +1 more source