Results 21 to 30 of about 142,607 (261)

Structural Insights into How Yrb2p Accelerates the Assembly of the Xpo1p Nuclear Export Complex

Cell Reports, 2014
Proteins and ribonucleoproteins containing a nuclear export signal (NES) assemble with the exportin Xpo1p (yeast CRM1) and Gsp1p-GTP (yeast Ran-GTP) in the nucleus and exit through the nuclear pore complex.
Masako Koyama, Natsuki Shirai, Yoshiyuki Matsuura   +2 more
doaj   +1 more source

Autism and mild epilepsy associated with a de novo missense pathogenic variant in the GTPase effector domain of DNM1

American Journal of Medical Genetics Part C: Seminars in Medical Genetics, EarlyView., 2023
Abstract Dynamin 1 is a GTPase protein involved in synaptic vesicle fission, which facilitates the exocytosis of neurotransmitters necessary for normal signaling. Pathogenic variants in the DNM1 gene are associated with intractable epilepsy, often manifested as infantile spasms at onset, developmental delay, and a movement disorder, and are located in ...
Davide Mei, Elena Parrini, Claudia Bianchini, Maria Luisa Ricci, Renzo Guerrini   +4 more
wiley   +1 more source

In silico docking of forchlorfenuron (FCF) to septins suggests that FCF interferes with GTP binding.

PLoS ONE, 2014
Septins are GTP-binding proteins that form cytoskeleton-like filaments, which are essential for many functions in eukaryotic organisms. Small molecule compounds that disrupt septin filament assembly are valuable tools for dissecting septin functions with
Dimitrios Angelis, Eva Pauline Karasmanis, Xiaobo Bai, Elias T Spiliotis   +3 more
doaj   +1 more source

ARF: the most misunderstood GTPase I ever knew - why study ARF GAPs

Frontiers in Molecular Biosciences
ADP-ribosylation factors (ARFs) are GTP-binding proteins that were discovered in the early 1980s, shortly after heterotrimeric GTP-binding proteins (G proteins) and nearly simultaneously with RAS.
Rachel E. Turn, Joel Bryan Dacks, Eric M. Rosenberg, Olivier Soubias, John K. Northup, Paul A. Randazzo   +5 more
doaj   +1 more source

IQGAP Family Members in Yeast, Dictyostelium, and Mammalian Cells

International Journal of Cell Biology, 2012
IQGAPs are a family of scaffolding proteins with multiple domains, named for the IQ motifs and GTPase activating protein (GAP) related domains. Despite their GAP homology, IQGAP proteins act as effectors for GTP-bound GTPases of the Ras superfamily and ...
Katie B. Shannon
doaj   +1 more source

The GTP- and Phospholipid-Binding Protein TTD14 Regulates Trafficking of the TRPL Ion Channel in Drosophila Photoreceptor Cells. [PDF]

PLoS Genetics, 2015
Recycling of signaling proteins is a common phenomenon in diverse signaling pathways. In photoreceptors of Drosophila, light absorption by rhodopsin triggers a phospholipase Cβ-mediated opening of the ion channels transient receptor potential (TRP) and ...
Alexander C Cerny, André Altendorfer, Krystina Schopf, Karla Baltner, Nathalie Maag, Elisabeth Sehn, Uwe Wolfrum, Armin Huber   +7 more
doaj   +1 more source

Divergent Mechanisms Activating RAS and Small GTPases Through Post-translational Modification

Frontiers in Molecular Biosciences, 2021
RAS is a founding member of the RAS superfamily of GTPases. These small 21 kDa proteins function as molecular switches to initialize signaling cascades involved in various cellular processes, including gene expression, cell growth, and differentiation ...
Natsuki Osaka, Yoshihisa Hirota, Yoshihisa Hirota, Doshun Ito, Doshun Ito, Yoshiki Ikeda, Ryo Kamata, Yuki Fujii, Yuki Fujii, Venkat R. Chirasani, Sharon L. Campbell, Koh Takeuchi, Toshiya Senda, Toshiya Senda, Toshiya Senda, Atsuo T. Sasaki, Atsuo T. Sasaki, Atsuo T. Sasaki, Atsuo T. Sasaki   +18 more
doaj   +1 more source

GTP-Binding Proteins and Regulated Exocytosis [PDF]

Critical Reviews in Oral Biology & Medicine, 1999
Regulated exocytosis, which occurs in response to stimuli, is a two-step process involving the docking of secretory granules (SGs) at specific sites on the plasma membrane (PM), with subsequent fusion and release of granule contents. This process plays a crucial role in a number of tissues, including exocrine glands, chromaffin cells, platelets, and ...
openaire   +2 more sources

Molecules and mechanisms that regulate multipolar migration in the intermediate zone

Frontiers in Cellular Neuroscience, 2014
Most neurons migrate with an elongated, bipolar morphology, extending a long leading process that explores the environment. However, when immature projection neurons enter the intermediate zone of the neocortex they become multipolar.
Jonathan A Cooper
doaj   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source