Results 171 to 180 of about 5,611 (205)

Regulation of GTP Cyclohydrolase I by Estrogen

2002
Estrogens are well known for their protective effects on the cardiovascular system (1,2). Activation of estrogen receptors which have been identified in endothelial and vascular smooth muscle cells leads to changes in gene expression and alterations in cellular function (3,4).
Christian Hesslinger, Z. Chen, Amrita Ahluwalia, David L. Selwood, Patrick Vallance, Josef Pfeilschifter, Aroon D. Hingorani   +6 more
openaire   +1 more source

Disruption of the GTP-Cyclohydrolase I Gene InSaccharomyces cerevisiae

Biochemical and Biophysical Research Communications, 1996
GTP-cyclohydrolase I is the first enzyme in the biosynthetic pathway leading to folic acid and tetrahydrobiopterin. We determined the complete sequence of the GTP-cyclohydrolase I gene from the yeast Saccharomyces cerevisiae. The gene, which is located in the subtelomeric region of the right arm of chromosome VII, gives a major transcript of about 1000
V, Nardese, M, Gütlich, A, Brambilla, M L, Carbone   +3 more
openaire   +2 more sources

Down-regulation of GTP cyclohydrolase I and tetrahydrobiopterin by melatonin

NeuroReport, 2000
Tetrahydrobiopterin (BH4) is spontaneously released and extracellularly exerts a toxic effect preferentially on catecholamine cells. Its synthesis rate is mainly determined by the activity of the enzyme GTP cyclohydrolase I (GTPCH). In the present study, role of melatonin BH4 synthesis was determined using the catecholaminergic CATH.a cells.
Y J, Jang, H N, Hong, J D, Lee, O, Hwang
openaire   +2 more sources

Detection and Quantification of GTP Cyclohydrolase I m RNA

1993
There is accumulating evidence that H4biopterin is synthesized in cells which do not depend on H4biopterin cofactor but undergo cytokine directed proliferation1. In this case, H4biopterin has a function which is apparently unrelated to its known cofactor role.
M, Gütlich, K, Schott, T, Werner, A, Bacher, I, Ziegler   +4 more
openaire   +2 more sources

Development of tetrahydrobiopterin and GTP cyclohydrolase in salivary glands of rats

International Journal of Biochemistry, 1986
A significant amount of 5,6,7,8-tetrahydrobiopterin (BH4), an essential cofactor of tyrosine hydroxylase, and the activity of GTP cyclohydrolase (GTP cycl), the first and rate-limiting enzyme in BH4 biosynthesis, were found in rat salivary glands, in which adrenergic transmitters are localized, from day 4 through 56 after birth.
S, Katoh, T, Sueoka
openaire   +2 more sources

GTP cyclohydrolase and tetrahydrobiopterin regulate pain sensitivity and persistence

Nature Medicine, 2006
We report that GTP cyclohydrolase (GCH1), the rate-limiting enzyme for tetrahydrobiopterin (BH4) synthesis, is a key modulator of peripheral neuropathic and inflammatory pain. BH4 is an essential cofactor for catecholamine, serotonin and nitric oxide production.
Irmgard, Tegeder, Michael, Costigan, Robert S, Griffin, Andrea, Abele, Inna, Belfer, Helmut, Schmidt, Corina, Ehnert, Jemiel, Nejim, Claudiu, Marian, Joachim, Scholz, Tianxia, Wu, Andrew, Allchorne, Luda, Diatchenko, Alexander M, Binshtok, David, Goldman, Jan, Adolph, Swetha, Sama, Steven J, Atlas, William A, Carlezon, Aram, Parsegian, Jörn, Lötsch, Roger B, Fillingim, William, Maixner, Gerd, Geisslinger, Mitchell B, Max, Clifford J, Woolf   +25 more
openaire   +2 more sources

Multiple mRNA forms of human GTP cyclohydrolase I

Biochemical and Biophysical Research Communications, 1992
To isolate full length cDNA clones encoding human GTP cyclohydrolase I, the first and rate-limiting enzyme in tetrahydrobiopterin biosynthesis, a cDNA library generated from human liver was screened by plaque hybridization. Analysis of the clones, hybridized with rat cDNA fragment, by restriction mapping and partial sequencing showed the existence of ...
A. Togari, H. Ichinose, S. Matsumoto, K. Fujita, T. Nagatsu   +4 more
openaire   +2 more sources

GTP-cyclohydrolase and vitiligo

The Lancet, 1997
Karin U Schallreuter, Nenad Blau
openaire   +1 more source

[GTP-cyclohydrolases of microorganisms and their role in metabolism].

Ukrainskii biokhimicheskii zhurnal (1978), 1985
The properties, regularities of biosynthesis and biochemical functions are considered of GTP-cyclohydrolases of microorganisms. The existence of two groups of these enzymes is established. The first group enzymes convert GTP into 7,8-dihydroneopterin-triphosphate and formiate.
G M, Shavlovskiĭ, E M, Logvinenko
openaire   +1 more source

Occurrence of GTP Cyclohydrolase I in

The Journal of Biochemistry, 1979
Yuzuru SUZUKI, Tadashi YASUI, Shigeo ABE
openaire   +1 more source