Results 161 to 170 of about 5,611 (205)
Induction of GTP cyclohydrolase I by bacterial lipopolysaccharide in the rat [PDF]
FEBS Letters, 1993 A 2‐ to 3‐fold increase of GTP cyclohydrolase I (E.C. 3.5.4.16), the key enzyme of tetrahydrobiopterin biosynthesis from GTP, was observed in cerebellum, remaining brain, liver, spleen, and adrenal gland of rats treated with a single dose of lipopolysaccharide (LPS). This led to increased biopterin levels in tissues but not in plasma.
Gabriele Werner-Felmayer +2 more
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Archives of Biochemistry and Biophysics, 2001
GTP cyclohydrolase I feedback regulatory protein (GFRP) mediates the feedback inhibition of GTP cyclohydrolase I activity by (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin (BH4) through protein complex formation. Since guanine and BH4 have a common pyrimidine ring structure, we examined the inhibitory effect of guanine and its analogs on the enzyme ...
Toshie Yoneyama, Kazuyuki Hatakeyama
exaly +3 more sources
GTP cyclohydrolase I feedback regulatory protein (GFRP) mediates the feedback inhibition of GTP cyclohydrolase I activity by (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin (BH4) through protein complex formation. Since guanine and BH4 have a common pyrimidine ring structure, we examined the inhibitory effect of guanine and its analogs on the enzyme ...
Toshie Yoneyama, Kazuyuki Hatakeyama
exaly +3 more sources
Ligand binding to the inhibitory and stimulatory GTP cyclohydrolase I/GTP cyclohydrolase I feedback regulatory protein complexes [PDF]
Protein Science, 2001 AbstractGTP cyclohydrolase I feedback regulatory protein (GFRP) mediates feedback inhibition of GTP cyclohydrolase I activity by 6R‐l‐erythro‐5,6,7,8‐tetrahydrobiopterin (BH4), which is an essential cofactor for key enzymes producing catecholamines, serotonin, and nitric oxide as well as phenylalanine hydroxylase.
Kazuyuki Hatakeyama, Toshie Yoneyama
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Species and tissue specificity of mammalian GTP cyclohydrolase I messenger RNA [PDF]
Biochimica Et Biophysica Acta Gene Regulatory Mechanisms, 1992 Northern blot analysis of rat RNA from cell lines and isolated organs with a specific rat cDNA probe detected two GTP cyclohydrolase I mRNA species of approx. 1.4 and 3.6 kb. The ratio between these two species varies between 0.6 and 2.4 in different rat
Markus Gütlich +2 more
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Inhibition of GTP cyclohydrolase I by pterins
Biochimica et Biophysica Acta (BBA) - General Subjects, 1988Pterins inhibit rat liver GTP cyclohydrolase I activity noncompetitively. Reduced pterins, such as 7,8-dihydro-D-neopterin, (6R,S)-5,6,7,8-tetrahydro-D-neopterin, 7,8-dihydro-L-biopterin, (6R)-5,6,7,8-tetrahydro-L-biopterin, L-sepiapterin, and DL-6-methyl-5,6,7,8-tetrahydropterin are approximately 12-times more potent as inhibitors than are oxidized ...
R S, Shen, A, Alam, Y X, Zhang
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Clinica Chimica Acta, 1985
An assay is described for GTP cyclohydrolase I activity in human mononuclear cells isolated from 20 ml of heparinized blood. The activity of this enzyme was low in unstimulated cells and increased 5-10 times after stimulation by phytohemagglutinin (formation of 0.8-1.3 pmol dihydroneopterin triphosphate/min per mg protein at 37 degrees C, n = 15) or ...
Nenad Blau +2 more
exaly +3 more sources
An assay is described for GTP cyclohydrolase I activity in human mononuclear cells isolated from 20 ml of heparinized blood. The activity of this enzyme was low in unstimulated cells and increased 5-10 times after stimulation by phytohemagglutinin (formation of 0.8-1.3 pmol dihydroneopterin triphosphate/min per mg protein at 37 degrees C, n = 15) or ...
Nenad Blau +2 more
exaly +3 more sources
Studies on GTP Cyclohydrolase I of Escherichia Coli
1993GTP cyclohydrolase I (EC 3.5.4.16) has been obtained from Escherichia coli wild type cells by affinity chromatography.1,2 The gene coding for the enzyme from E. coli has been cloned and sequenced3,4 and has been mapped at 2251 kb of the physical map of the E.
Cornelia Schmid +10 more
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GTP-cyclohydrolases: a review.
Journal of clinical chemistry and clinical biochemistry. Zeitschrift fur klinische Chemie und klinische Biochemie, 1985The occurrence, properties and functions of GTP-cyclohydrolases in mammalian and non-mammalian systems is reviewed. GTP-cyclohydrolases catalyse the removal of C-8 atom from GTP as formic acid. GTP-cyclohydrolase I (EC 3.5.4.16) converts GTP into D-erythro-7, 8-dihydroneopterin triphosphate, whereas GTP-cyclohydrolase II forms 2,5-diamino-4-oxo-6-(5 ...
N, Blau, A, Niederwieser
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GTP-cyclohydrolase-I like immunoreactivity in rat brain [PDF]
Brain Research, 1997 GTPCH-I immunoreactive structures in the rat brain were studied using a polyclonal antibody raised in the chick. General mapping was made using the avidin-biotin-peroxidase technique and compared with the distribution of tyrosine hydroxylase and serotonin immunoreactivities.
Dassesse, Donald +3 more
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Mutations in GTP-cyclohydrolase I gene and vitiligo
The Lancet, 1997Sporadic and familial cases of vitiligo, some of them associated with autoimmune endocrine disorders, have been described. Although an autosomal dominant inheritance with low penetrance is suspected, no genetic locus has yet been identified. It has been shown that tetrahydrobiopterin regulates melanin biosynthesis, and that patients with vitiligo have ...
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