Results 141 to 150 of about 137,270 (354)

The KDEL receptor, ERD2, regulates intracellular traffic by recruiting a GTPase-activating protein for ARF1 [PDF]

, 1997
Tomohiko Aoe
openalex   +1 more source

The Ras GTPase ‐activating‐like protein IQGAP1 bridges Gasdermin D to the ESCRT system to promote IL ‐1β release via exosomes [PDF]

, 2022
Yun Liao, Xing Chen, William A. Miller-Little, Han Wang, Belinda Willard, Katarzyna Bulek, Junjie Zhao, Xiaoxia Li   +7 more
openalex   +1 more source

CD28 and the Tyrosine Kinase Lck Stimulate Mitogen-Activated Protein Kinase Activity in T Cells via Inhibition of the Small G Protein Rap1

, 2000
Proliferation of T cells via activation of the T-cell receptor (TCR) requires concurrent engagement of accessory costimulatory molecules to achieve full activation.
Baird, Allison M, Carey, Kendall D, Dillon, Tara J, Holdorf, Amy D, Schmitt, John M, Shaw, Andrey S, Stork, Philip J. S., Straus, David B   +7 more
core   +2 more sources

Biomechanical Phenotyping Reveals Unique Mechanobiological Signatures of Early‐Onset Colorectal Cancer

Advanced Science, EarlyView.
This study identifies a unique physical signature of colorectal cancer in younger adults: their tissues are mechanically stiffer than those in older patients with the same cancer. Furthermore, stromal remodeling in early‐onset colorectal cancer promotes epithelial mechanotransduction and proliferation, showing how mechanical alterations in the tissue ...
Nicole C. Huning, Munir H. Buhaya, Victor V. Nguyen, Afeefah Khazi‐Syed, Haider A. Ali, Adil Khan, Angela Fan, Robert C. Fisher, Zhikai Chi, Indu Raman, Guangchun Chen, Chengsong Zhu, Mengxi Yu, Andrew R. Jamieson, Sara Roccabianca, Victor D. Varner, Cheryl M. Lewis, Emina H. Huang, Jacopo Ferruzzi   +18 more
wiley   +1 more source

Sdd3 regulates the biofilm formation of Candida albicans via the Rho1-PKC-MAPK pathway

mBio
Candida albicans, the most frequently isolated fungal pathogen in humans, forms biofilms that enhance resistance to antifungal drugs and host immunity, leading to frequent treatment failure.
Li Mei Pang, Guisheng Zeng, Eve Wai Ling Chow, Xiaoli Xu, Ning Li, Yee Jiun Kok, Shu Chen Chong, Xuezhi Bi, Jiaxin Gao, Chaminda Jayampath Seneviratne, Yue Wang   +10 more
doaj   +1 more source

Targeting G3BP1 Condensate Topology Promotes Stress Granule Assembly via m6A‐IGF2BP1 for Ischemic Stroke Rescue

Advanced Science, EarlyView.
Our research reveals that small‐molecule icariin (ICA) directly binds Ras‐GTPase‐activating protein SH3 domain‐binding protein 1 (G3BP1), inducing conformational change and oligomerization. This interaction confers neuroprotection by recruiting insulin‐like growth factor 2 mRNA‐binding protein 1 (IGF2BP1) and modulating N6‐methyladenosine (m6A ...
Ling Li, Yong‐Dong Guo, Xiao‐Wen Zhang, Zhi‐Yong Du, Yu‐Qi Wang, Zhuo Yang, Qian‐Wei Luo, Fang‐Fang Zhuo, Tian‐Tian Wei, Zheng‐Ping Liu, Bo Han, Wei Yu, Pei‐Pei Zhang, Wei Zhou, Zhi‐Yuan Lu, Peng‐Fei Tu, Chun‐Hong Zheng, Ke‐Wu Zeng   +17 more
wiley   +1 more source

A report on rosuvastatin’s role in alleviating behavioral problems in autism spectrum disorder with a SYNaptic GTPase-Activating Protein 1 mutation

Archives of Mental Health
SYNaptic GTPase-Activating Protein 1 (SYNGAP1) is a gene that encodes the cytosolic protein SYNGAP1, an essential component of the postsynaptic density at excitatory glutamatergic neurons.
Vishnupriya Veeraraghavan, Shabnam Kalita, Sreejana Sharma, Kaushik Ragunathan, Jaya Shankar Kaushik   +4 more
doaj   +1 more source

Chloroplast Stress Signals Orchestrate Epidermis‐Specific Remodeling of Mitochondria and ER Under High Light

Advanced Science, EarlyView.
High light exposure triggers an epidermis‐specific remodeling of mitochondria and ER in Arabidopsis, driven by chloroplast‐derived signals. Live‐cell imaging shows that HL rapidly suppresses mitochondrial motility, followed by fusion‐driven elongation and ER cisternal expansion.
Evan R. Angelos, Hee‐Seung Choi, Jingzhe Guo, Andrea A. Zanini, Tessa M. Burch‐Smith, Emily Snyder, Matthew Part, Wilhelmina van de Ven, Manhoi Hur, Gerd Ulrich Balcke, Alain Tissier, Quanqing Zhang, Katayoon Dehesh   +12 more
wiley   +1 more source

Malignant progression of liver cancer progenitors requires lysine acetyltransferase 7–acetylated and cytoplasm‐translocated G protein GαS

Hepatology, EarlyView., 2022
KAT7‐acetylated and cytoplasm‐translocated G‐protein GαS enhances IL‐6 effect and drives HCC progenitor cell progression. Abstract Background and Aims Hepatocarcinogenesis goes through HCC progenitor cells (HcPCs) to fully established HCC, and the mechanisms driving the development of HcPCs are still largely unknown.
Ye Zhou, Kaiwei Jia, Suyuan Wang, Zhenyang Li, Yunhui Li, Shan Lu, Yingyun Yang, Liyuan Zhang, Mu Wang, Yue Dong, Luxin Zhang, Wannian Zhang, Nan Li, Yizhi Yu, Xuetao Cao, Jin Hou   +15 more
wiley   +1 more source

Tumor Cell Migration and Invasion Are Enhanced by Depletion of Rap1 GTPase-activating Protein (Rap1GAP) [PDF]

, 2013
Oxana M. Tsygankova, Hongbin Wang, Judy L. Meinkoth   +2 more
openalex   +1 more source