Results 1 to 10 of about 1,798,469 (249)

Role of IQ Motif-Containing GTPase-Activating Proteins in Hepatocellular Carcinoma [PDF]

Frontiers in Oncology, 2022
IQ motif-containing GTPase-activating proteins (IQGAPs) are a class of scaffolding proteins, including IQGAP1, IQGAP2, and IQGAP3, which govern multiple cellular activities by facilitating cytoskeletal remodeling and cellular signal transduction.
Qingqing Dai, Qingqing Dai, Quratul Ain, Michael Rooney, Fei Song, Alexander Zipprich   +5 more
doaj   +2 more sources

The roles of GTPase-activating proteins in regulated cell death and tumor immunity [PDF]

Journal of Hematology & Oncology, 2021
GTPase-activating protein (GAP) is a negative regulator of GTPase protein that is thought to promote the conversion of the active GTPase-GTP form to the GTPase-GDP form.
Hua He, Jingjing Huang, Sufang Wu, Shiyao Jiang, Lu Liang, Yueying Liu, Wenbing Liu, Li Xie, Yongguang Tao, Yiqun Jiang, Li Cong   +10 more
doaj   +2 more sources

Ras GTPase-activating proteins control neuronal circuit development in barrel cortex layer 4 [PDF]

Frontiers in Neuroscience, 2022
The cerebral cortex comprises a complex and exquisite network of neuronal circuits that is formed during development. To explore the molecular mechanisms involved in cortical circuit formation, the tactile somatosensory pathway that connects the whiskers
Madhura S. Rao, Madhura S. Rao, Hiromi Mizuno, Hiromi Mizuno, Takuji Iwasato, Takuji Iwasato, Hidenobu Mizuno, Hidenobu Mizuno   +7 more
doaj   +2 more sources

Computational model explains high activity and rapid cycling of Rho GTPases within protein complexes. [PDF]

PLoS Computational Biology, 2006
Formation of multiprotein complexes on cellular membranes is critically dependent on the cyclic activation of small GTPases. FRAP-based analyses demonstrate that within protein complexes, some small GTPases cycle nearly three orders of magnitude faster ...
Andrew B Goryachev, Alexandra V Pokhilko
doaj   +3 more sources

Watch the GAP: Emerging Roles for IQ Motif-Containing GTPase-Activating Proteins IQGAPs in Hepatocellular Carcinoma [PDF]

International Journal of Hepatology, 2012
IQ motif-containing GTPase-activating proteins IQGAP1 and IQGAP2 are highly homologous multidomain scaffolding proteins. Their major function consists of integration of Rho GTPase and Ca2+/calmodulin signals with cell adhesive and cytoskeletal ...
Valentina A. Schmidt
doaj   +2 more sources

Decoding Rho GTPase signalling networks in directed cell migration [PDF]

Frontiers in Cell and Developmental Biology
Small G proteins are molecular switches in the realm of cell biology, switching from the GTP-bound active form to the GDP-bound inactive form. They participate in controlling various essential cellular functions, one of which is cell migration.
Yasaswi Gayatri Mishra, A. Indumathi, Saratchandra Singh Khumukcham, Bramanandam Manavathi   +3 more
doaj   +2 more sources

Arf GTPase-Activating proteins ADAP1 and ARAP1 regulate incorporation of CD63 in multivesicular bodies [PDF]

Biology Open
Kasumi Suzuki, Yoshitaka Okawa, Sharmin Akter, Haruki Ito, Yoko Shiba   +4 more
doaj   +2 more sources

Roles of G proteins and their GTPase-activating proteins in platelets. [PDF]

Biosci Rep
Platelets are small anucleate blood cells supporting vascular function. They circulate in a quiescent state monitoring the vasculature for injuries. Platelets adhere to injury sites and can be rapidly activated to secrete granules and to form platelet ...
O'Donoghue L, Smolenski A.
europepmc   +5 more sources

Fixing the GAP: The role of RhoGAPs in cancer

European Journal of Cell Biology, 2022
Cancer progression and metastasis are processes that involve significant cellular changes. Many of these changes include alterations in the activity of the Rho GTPase family of proteins.
Gabriel Kreider-Letterman, Nicole M. Carr, Rafael Garcia-Mata   +2 more
doaj   +1 more source

ADP-Ribosylation Factor Family of Small GTP-Binding Proteins: Their Membrane Recruitment, Activation, Crosstalk and Functions

Frontiers in Cell and Developmental Biology, 2022
Members of the ADP-ribosylation factor (ARF) family of guanine-nucleotide binding proteins play critical roles in various cellular processes, especially in regulating the secretory, and endocytic pathways.
Tiantian Li, Yusong Guo, Yusong Guo, Yusong Guo   +3 more
doaj   +1 more source