Results 181 to 190 of about 14,319 (272)

Novel para‐phenylenediamine‐based derivatives as Receptor Tyrosine Kinase‐like Orphan Receptor 1 (ROR1) Inhibitors: An in vitro preliminary characterization

ChemMedChem, Accepted Article.
ROR1 kinase is an underexplored promising target for the development of novel anticancer drugs, being strongly expressed in several cancer cell lines, but poorly in non‐tumor cells. This property, together with the scarce number of molecules effective against ROR1, led us to design and develop a research program aimed to the discovery of new chemical ...
Gerardina Smaldone, Maria Rosaria Miranda, Francesca Di Matteo, Valeria Napolitano, Michela Aliberti, Simona Musella, Veronica Di Sarno, Gianluigi Lauro, Giuseppe Bifulco, Giacomo Pepe, Giovanna Aquino, Mario Felice Tecce, Isabel Maria Gomez-Monterrey, Pietro Campiglia, Carmine Ostacolo, Alessia Bertamino, Vincenzo Vestuto, Tania CIAGLIA   +17 more
wiley   +1 more source

The RGG motif proteins: Interactions, functions, and regulations

WIREs RNA, Volume 14, Issue 1, January/February 2023., 2023
RGG motif proteins play vital roles in the translation process from mRNA transport to translational regulation. Functions of RGG motif proteins depend on their ability to bind to RNAs and proteins, localize to various compartments of the cell and post‐translational modifications.
Mashiat N. Chowdhury, Hong Jin
wiley   +1 more source

Interaction of two proline-rich sequences of cell adhesion kinase β with SH3 domains of p130Cas-related proteins and a GTPase-activating protein, Graf [PDF]

, 1998
Takeaki Ohba, Masaho Ishino, Hiroshi Aoto, Terukatsu Sasaki   +3 more
openalex   +1 more source

Harnessing Viral Proteases for Cellular and Molecular Engineering

Chemistry–Methods, EarlyView.
Engineered viral proteases (VIPs) provide programmable control of protein function with high specificity and low toxicity. Integrated with chemogenetic and optogenetic modules, these VIP systems enable logic gate manipulation for targeted regulation of cell signaling, gene expression, protein secretion, and degradation, thereby offering versatile ...
Mingguang Cui, Tien‐Hung Lan, Yubin Zhou   +2 more
wiley   +1 more source

Dynamic regulation of the transcriptome and proteome of the equine embryo during maternal recognition of pregnancy

FASEB BioAdvances, Volume 4, Issue 12, Page 775-797, December 2022., 2022
Abstract During initial maternal recognition of pregnancy (MRP), the equine embryo displays a series of unique events characterized by rapid blastocyst expansion, secretion of a diverse array of molecules, and transuterine migration to interact with the uterine surface.
Alba Rudolf Vegas, Giorgia Podico, Igor F. Canisso, Heinrich Bollwein, Thomas Fröhlich, Stefan Bauersachs, Carmen Almiñana   +6 more
wiley   +1 more source

The LIM Domain-Containing Dbm1 GTPase-Activating Protein Is Required for Normal Cellular Morphogenesis in Saccharomyces cerevisiae [PDF]

, 1996
Guang-Chao Chen, Zheng Li, Clarence S.M. Chan   +2 more
openalex   +1 more source

Molecular profiles of single circulating tumor cells from early breast cancer patients with different lymph node statuses

Thoracic Cancer, Volume 14, Issue 2, Page 156-167, January 2023., 2023
Circulating tumor cells (CTCs) were clustered into two subtypes significantly correlated with the lymph node metastasis status of early breast cancer patients. Patients with lymph node metastasis have CTCs that express an epithelial/stem‐like pattern of metastasis initiating cells, while those patients without lymph node metastasis have CTCs that have ...
Shuyun Pang, Shu Xu, Lulu Wang, Haiping Wu, Yanan Chu, Xueping Ma, Yujiao Li, Bingjie Zou, Shaohua Wang, Guohua Zhou   +9 more
wiley   +1 more source

Botulinum toxin-catalyzed ADP-ribosylation of Gb (rho gene product). 4. Partial purification and characterization of rho-specific GTPase Activating Protein (rho GAP)

, 1990
Akihiro Sekine, Shuh Narumiya, Motohatsu Fujiwara   +2 more
openalex   +1 more source

Clinical and plasma proteomic characterization of heart failure with supranormal left ventricular ejection fraction: An emerging entity of heart failure

European Journal of Heart Failure, EarlyView.
Heart failure (HF) with supranormal ejection fraction (HFsnEF) is an unnoticed but emerging entity in HF. This study showed that HFsnEF carries a similarly increased cardiovascular risk as HF with reduced ejection fraction (HFrEF) and distinct structural and proteomic characteristics from HFrEF, warranting a further comprehensive understanding and ...
Yasuhiko Sakata, Kotaro Nochioka, Satoshi Yasuda, Koichi Ishida, Takashi Shiroto, Jun Takahashi, Shintaro Kasahara, Ruri Abe, Shinsuke Yamanaka, Takahide Fujihashi, Hideka Hayashi, Shintaro Kato, Katsunori Horii, Kanako Teramoto, Tsutomu Tomita, Satoshi Miyata, Koichiro Sugimura, Iwao Waga, Masao Nagasaki, Hiroaki Shimokawa   +19 more
wiley   +1 more source

Proliferation and differentiation of rat pheochromocytoma PC12 cells were affected by the overexpression of p21ras GTPase activating proteins or expression of its deletion mutant proteins.

, 1994
Hiroko Nakata, Hidenori Sasa, Koji Tomiyama, Yasuhiro Watanabe   +3 more
openalex   +1 more source