Results 321 to 330 of about 958,866 (334)

Chick kainate binding protein lacks GTPase activity

NeuroReport, 1999
Chick kainate binding protein was solubilized from cerebellar membranes and purified (x19) by use of two chromatographic steps. Measurements of [3H]kainate binding and GTPase activity in the different fractions reveal a consistent decrease of GTPase activity as the purification proceeds so that no GTPase is detectable after the final purification step.
Tasca, C.I., Burgos, J.S., Barat, A., Souza, D.O., Ramírez Jofré, Galo   +4 more
openaire   +4 more sources

p115 Rho GTPase activating protein interacts with MEKK1

Journal of Cellular Physiology, 2002
AbstractMammalian MAP/ERK kinase kinase 1 (MEKK1) was identified as a mammalian homolog of Ste11p of the yeast pheromone‐induced mating pathway. Like Ste11p, MEKK1 is a MAP3 kinase linked to at least two MAP kinase cascades and regulatory events that require cytoskeletal reorganization. MEKK1 is activated by molecules that impact cytoskeletal function.
Ewen D. Gallagher, Clark D. Wells, Roxana Kazempour, Angelique W. Whitehurst, Melanie H. Cobb, Lori B. Christerson, Paul C. Sternweis, Colleen A. Vanderbilt   +7 more
openaire   +3 more sources

The Role of ras GTPase Activating Protein in Human Tumorigenesis [PDF]

Pathobiology, 1995
Abnormal signal transduction involving activated ras genes plays a major role in the development of a variety of tumors. Ras GTPase-activating protein (rasGAP) is a major contributor to the downregulation of ras by facilitating GTP hydrolysis of activated ras. In addition, GAP participates in the down-stream effector system of the ras signaling pathway.
openaire   +2 more sources

Suppression of c-ras transformation by GTPase-activating protein

Nature, 1990
The ras genes are required for normal cell growth and mediate transformation by oncogenes encoding protein tyrosine kinases. Normal ras can transform cells in vitro and in vivo, but mutationally activated ras does so much more efficiently, and highly transforming mutant versions of ras have been isolated from a variety of human and animal tumours.
Alex G. Papageorge, Frank McCormick, Douglas R. Lowy, William C. Vass, Jeffrey E. DeClue, Ke Zhang   +5 more
openaire   +3 more sources

The Semaphorin 4D Receptor Plexin-B1 Is a GTPase Activating Protein for R-Ras

Science, 2004
Izumi Oinuma, Yukio Ishikawa, H. Katoh, M. Negishi   +3 more
semanticscholar   +1 more source

Overexpression of Ras‐GTPase‐activating protein SH3 domain‐binding protein 1 correlates with poor prognosis in gastric cancer patients

Histopathology, 2015
L. Min, Yuanyuan Ruan, Zhenbin Shen, Dongwei Jia, Xuefei Wang, Junjie Zhao, Yihong Sun, J. Gu   +7 more
semanticscholar   +1 more source

The ARF1 GTPase-Activating Protein: Zinc Finger Motif and Golgi Complex Localization

Science, 1995
E. Cukierman, I. Huber, M. Rotman, D. Cassel   +3 more
semanticscholar   +1 more source

The N-terminal Domain of Pseudomonas aeruginosaExoenzyme S Is a GTPase-activating Protein for Rho GTPases*

Journal of Biological Chemistry, 1999
U. Goehring, G. Schmidt, K. J. Pederson, K. Aktories, J. Barbieri   +4 more
semanticscholar   +1 more source

Quantitative Assays for GTPase-Activating Proteins

2002
openaire   +3 more sources

Structure at 1.65 Å of RhoA and its GTPase-activating protein in complex with a transition-state analogue

Nature, 1997
K. Rittinger, P. Walker, J. Eccleston, S. Smerdon, S. Gamblin   +4 more
semanticscholar   +1 more source