Results 91 to 100 of about 1,011,564 (289)

Molecular mechanisms of Sar/Arf GTPases in vesicular trafficking in yeast and plants

Frontiers in Plant Science, 2014
Small GTPase proteins play essential roles in the regulation of vesicular trafficking systems in eukaryotic cells. Two types of small GTPases, secretion-associated Ras-related protein (Sar) and ADP-ribosylation factor (Arf), act in the biogenesis of ...
Tomohiro eYorimitsu, Ken eSato, Masaki eTakeuchi   +2 more
doaj   +1 more source

RGS4 and GAIP are GTPase-activating proteins for Gq alpha and block activation of phospholipase C beta by gamma-thio-GTP-Gq alpha.

Proceedings of the National Academy of Sciences of the United States of America, 1997
RGS proteins constitute a newly appreciated and large group of negative regulators of G protein signaling. Four members of the RGS family act as GTPase-activating proteins (GAPs) with apparent specificity for members of the Gi alpha subfamily of G ...
J. Hepler, D. M. Berman, A. Gilman, T. Kozasa   +3 more
semanticscholar   +1 more source

The Sec14-like phosphatidylinositol transfer proteins Sec14l3/SEC14L2 act as GTPase proteins to mediate Wnt/Ca2+ signaling

eLife, 2017
The non-canonical Wnt/Ca2+ signaling pathway plays important roles in embryonic development, tissue formation and diseases. However, it is unclear how the Wnt ligand-stimulated, G protein-coupled receptor Frizzled activates phospholipases for calcium ...
Bo Gong, Weimin Shen, Wanghua Xiao, Yaping Meng, Anming Meng, Shunji Jia   +5 more
doaj   +1 more source

Molecular mechanism of Gαi activation by non-GPCR proteins with a Gα-Binding and Activating motif [PDF]

, 2017
Heterotrimeric G proteins are quintessential signalling switches activated by nucleotide exchange on Gα. Although activation is predominantly carried out by G-protein-coupled receptors (GPCRs), non-receptor guanine-nucleotide exchange factors (GEFs) have
Baillie, George S., Blanco, Francisco J., Blanco-Canosa, Juan B., Cerione, Richard A., de la Cruz-Morcillo, Miguel Angel, DiGiacomo, Vincent, Garcia-Marcos, Mikel, Ibáñez de Opakua, Alain, Leyme, Anthony, Marivin, Arthur, Merino, Nekane, Nguyen, Lien T., Parag-Sharma, Kshitij, Ramachandran, Sekar, Villate, Maider   +14 more
core   +1 more source

PAKing up to the endothelium [PDF]

, 2009
Angiogenesis recapitulates the growth of blood vessels that progressively expand and remodel into a highly organized and stereotyped vascular network. During adulthood, endothelial cells that formed the vascular wall retain their plasticity and can be ...
Armelle Le Guelte, Eva Maria, Galan Moya, Julie Gavard   +3 more
core   +6 more sources

ARHGAP21 (Rho GTPase activating protein 21) [PDF]

Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2018
ARHGAP21 is a Rho GTPase-activating protein (RhoGAP). Like other members of the RhoGAP family, ARHGAP21 enhances the intrinsic GTPase activity of small Rho GTPases, leading to their inactivation. ARHGAP21 participates in cellular proliferation, adhesion, migration and vesicle traffic.
Ferreira Pissarra, Mariana, Olalla Saad, Sara Teresinha, Lazarini, Mariana   +2 more
openaire   +2 more sources

Dlc1 interaction with non-muscle myosin heavy chain II-A (Myh9) and Rac1 activation

Biology Open, 2016
The Deleted in liver cancer 1 (Dlc1) gene codes for a Rho GTPase-activating protein that also acts as a tumour suppressor gene. Several studies have consistently found that overexpression leads to excessive cell elongation, cytoskeleton changes and ...
Mohammad G. Sabbir, Rachelle Dillon, Michael R. A. Mowat   +2 more
doaj   +1 more source

ARHGAP20 (Rho GTPase activating protein 20) [PDF]

Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2011
Review on ARHGAP20 (Rho GTPase activating protein 20), with data on DNA, on the protein encoded, and where the gene is implicated.
openaire   +2 more sources

The coordination of cell growth during fission yeast mating requires Ras1-GTP hydrolysis [PDF]

, 2013
The spatial and temporal control of polarity is fundamental to the survival of all organisms. Cells define their polarity using highly conserved mechanisms that frequently rely upon the action of small GTPases, such as Ras and Cdc42.
A Merla, B Onken, C Banning, C Vanni, Cathryn Weston, DA Hughes, EC Chang, FD Kelly, FO Bendezú, FS Wouters, G Ladds, G Ladds, G Ladds, G Ladds, G Ladds, G Ladds, Graham Ladds, H Murakoshi, H Tatebe, H Tu, I Tratner, J Davey, J Davey, J Davey, J Marks, JL Brown, JM Mitchison, Juan Mata, K Hirota, K Kitamura, K Maundrell, K Nakano, K Scheffzek, M Das, M Didmon, M Hachet-Haas, M Hamilton, M Malumbres, M Toya, MD Abramoff, Michael Bond, O Nielsen, P Fantes, P García, P Gideon, P Papadaki, PM Coll, R Egel, S Ottilie, S Sazer, SA Rincón, SR Sprang, T Masuda, TT Maeda, V Jung, V Snell, Wayne Croft, Y Imai, Y Imai   +58 more
core   +3 more sources

Tuberous Sclerosis Tumor Suppressor Complex-like Complexes Act as GTPase-activating Proteins for Ral GTPases*

Journal of Biological Chemistry, 2009
The small GTPases RalA and RalB are multifunctional proteins regulating a variety of cellular processes. Like other GTPases, the activity of Ral is regulated by the opposing effects of guanine nucleotide exchange factors (GEFs) and GTPase-activating ...
R. Shirakawa, S. Fukai, Mitsunori Kawato, T. Higashi, H. Kondo, Tomoyuki Ikeda, E. Nakayama, K. Okawa, O. Nureki, Takeshi Kimura, T. Kita, H. Horiuchi   +11 more
semanticscholar   +1 more source