Results 101 to 110 of about 1,011,564 (289)
Reciprocal regulation of PKA and rac signaling [PDF]
, 2013 Activated G protein-coupled receptors (GPCRs) and receptor tyrosine kinases relay extracellular signals through spatial and temporal controlled kinase and GTPase entities.
A. Riml +47 more
core +1 more source
Rapid GTP binding and hydrolysis by G(q) promoted by receptor and GTPase-activating proteins.
Proceedings of the National Academy of Sciences of the United States of America, 1999 Receptor-promoted GTP binding and GTPase-activating protein (GAP)-promoted GTP hydrolysis determine the onset and termination of G protein signaling; they coordinately control signal amplitude.
S. Mukhopadhyay, E. Ross
semanticscholar +1 more source
Synaptic GAP and GEF Complexes Cluster Proteins Essential for GTP Signaling
Scientific Reports, 2017 GTPase-activating proteins (GAPs) and guanine exchange factors (GEFs) play essential roles in regulating the activity of small GTPases. Several GAPs and GEFs have been shown to be present at the postsynaptic density (PSD) within excitatory glutamatergic ...
Brent Wilkinson +2 more
doaj +1 more source
Deconstruction of the Ras switching cycle through saturation mutagenesis
eLife, 2017 Ras proteins are highly conserved signaling molecules that exhibit regulated, nucleotide-dependent switching between active and inactive states. The high conservation of Ras requires mechanistic explanation, especially given the general mutational ...
Pradeep Bandaru +10 more
doaj +1 more source
GAP1 Family Members Constitute Bifunctional Ras and Rap GTPase-activating Proteins*
Journal of Biological Chemistry, 2006 GAP1IP4BP is a member of the GAP1 family of Ras GTPase-activating proteins (Ras GAPs) that includes GAP1m, CAPRI, and RASAL. Composed of a central Ras GAP domain, surrounded by amino-terminal C2 domains and a carboxyl-terminal pleckstrin homology/Bruton ...
S. Kupzig +10 more
semanticscholar +1 more source
Cell Reports, 2021 Summary: Cdc42 GTPase rules cell polarity and growth in fission yeast. It is negatively and positively regulated by GTPase-activating proteins (GAPs) and guanine nucleotide exchange factors (GEFs), respectively.
Clàudia Salat-Canela +5 more
doaj
Dysregulated GPCR Signaling and Therapeutic Options in Uveal Melanoma. [PDF]
, 2017 Uveal melanoma is the most common primary intraocular malignant tumor in adults and arises from the transformation of melanocytes in the uveal tract. Even after treatment of the primary tumor, up to 50% of patients succumb to metastatic disease.
Aplin, Andrew E. +5 more
core +1 more source
Two New Members of a Family of Ypt/Rab GTPase Activating Proteins
Journal of Biological Chemistry, 1999 Monomeric GTPases of the Ras superfamily have a very slow intrinsic GTPase activity which is accelerated by specific GTPase-activating proteins. In contrast to Ras- and Rho-specific GTPase-activating proteins (GAPs) that have been studied in great detail,
S. Albert, D. Gallwitz
semanticscholar +1 more source
Phospholipases as GTPase activity accelerating proteins (GAPs) in plants [PDF]
Plant Signaling & Behavior, 2016 GTPase activity accelerating proteins (GAPs) are key regulators of the G-protein signaling cycle. By facilitating effective hydrolysis of the GTP bound on Gα proteins, GAPs control the timing and amplitude of the signaling cycle and ascertain the availability of the inactive heterotrimer for the next round of activation.
openaire +3 more sources
Lrg1 Regulates β (1,3)-Glucan Masking in
mBio, 2019 Candida albicans is among the most prevalent opportunistic human fungal pathogens. The ability to mask the immunogenic polysaccharide β (1,3)-glucan from immune detection via a layer of mannosylated proteins is a key virulence factor of C. albicans.
Tian Chen +7 more
doaj +1 more source