Results 111 to 120 of about 1,011,564 (289)

Specific Involvement of G Proteins in Regulation of Serum Response Factor-mediated Gene Transcription by Different Receptors [PDF]

, 1998
Regulation of serum response factor (SRF)-mediated gene transcription by G protein subunits and G protein-coupled receptors was investigated in transfected NIH3T3 cells and in a cell line that was derived from mice lacking G_(αq) and G_(α11).
Mao, Junhao, Simon, Melvin I., Wu, Dianqing, Xie, Wei, Yuan, Huidong   +4 more
core   +1 more source

Functional specialization of the yeast Rho1 GTP exchange factors [PDF]

, 2012
Rho GTPases are regulated in complex spatiotemporal patterns that may be dependent, in part at least, on the multiplicity of their GTP exchange factors (GEFs).
Cundell, M., Gray, J., Johnston, G., Krause, S., McGhie, J., Poon, P., Price, C.   +6 more
core  

Importin-beta and CRM1 control a RANBP2 spatiotemporal switch essential for mitotic kinetochore function [PDF]

, 2017
Protein conjugation with small ubiquitin-related modifier (SUMO) is a post-translational modification that modulates protein interactions and localisation.
Damizia, Michela, DE SANTIS, RICCARDO, DE TURRIS, VALERIA, GILISTRO, EUGENIA, Lavia, Patrizia, MORONI, SARA, ROSA, ALESSANDRO, VERRICO, ANNALISA   +7 more
core   +1 more source

The GIT Family of ADP-ribosylation Factor GTPase-activating Proteins

Journal of Biological Chemistry, 2000
We recently characterized a novel protein, GIT1, that interacts with G protein-coupled receptor kinases and possesses ADP-ribosylation factor (ARF) GTPase-activating protein activity. A second ubiquitously expressed member of the GIT protein family, GIT2,
R. Premont, A. Claing, N. Vitale, S. Perry, R. Lefkowitz   +4 more
semanticscholar   +1 more source

Membrane and Protein Interactions of the Pleckstrin Homology Domain Superfamily. [PDF]

, 2015
The human genome encodes about 285 proteins that contain at least one annotated pleckstrin homology (PH) domain. As the first phosphoinositide binding module domain to be discovered, the PH domain recruits diverse protein architectures to cellular ...
Abagyan, Ruben, Kufareva, Irina, Lenoir, Marc, Overduin, Michael   +3 more
core   +3 more sources

Regulation of Synaptic Rac1 Activity, Long-Term Potentiation Maintenance, and Learning and Memory by BCR and ABR Rac GTPase-Activating Proteins

Journal of Neuroscience, 2010
Rho family small GTPases are important regulators of neuronal development. Defective Rho regulation causes nervous system dysfunctions including mental retardation and Alzheimer's disease.
Daeyoung Oh, Seungnam Han, Jinsoo Seo, Jae-Ran Lee, Jeonghoon Choi, J. Groffen, Karam Kim, Y. Cho, Han-Seam Choi, Hyewon Shin, Jooyeon Woo, H. Won, Soon Kwon Park, Soo-Young Kim, J. Jo, Daniel J. Whitcomb, Kwangwook Cho, Hyun Kim, Y. Bae, N. Heisterkamp, Se-Young Choi, Eunjoon Kim   +21 more
semanticscholar   +1 more source

Differential stimulation of the GTPase activity of G-proteins by polylysine

Biochemical Pharmacology, 1992
Polylysine, polyornithine and, to a lesser extent, polyarginine were found to stimulate the GTPase activity of the purified recombinant alpha subunit of the human G(i)-3 transducing protein alpha i-3. Optimal stimulation of 4- to 5-fold was obtained with polylysine concentrations between 1 and 20 microM, higher concentrations being inhibitory ...
Antonelli, Marcelo, Olate, Juan, Graf, Rolf, Allende, Catherine C., Allende, Jorge E.   +4 more
openaire   +4 more sources

RAB22A sorts epithelial growth factor receptor (EGFR) from early endosomes to recycling endosomes for microvesicles release

Journal of Extracellular Vesicles
Microvesicles (MVs) containing proteins, nucleic acid or organelles are shed from the plasma membrane. Although the mechanisms of MV budding are well elucidated, the connection between endosomal trafficking and MV formation remains poorly understood.
Yujie Lin, Denghui Wei, Xiaobo He, Lanqing Huo, Jingxuan Wang, Xia Zhang, Yuanzhong Wu, Ruhua Zhang, Ying Gao, Tiebang Kang   +9 more
doaj   +1 more source

Regulators of G protein signalling proteins in the human myometrium [PDF]

, 2009
The contractile state of the human myometrium is controlled by extracellular signals that promote relaxation or contraction. Many of these signals function through G proteincoupled receptors at the cell surface, stimulating heterotrimeric G proteins and ...
Abramow-Newerly, Ballon, Bansal, Benians, Bernstein, Blanks, Brodt-Eppley, Chatterjee, Cho, De Vries, Dohlman, Druey, Europe-Finner, Georgoussi, Graham Ladds, Hague, Hao, Hepler, Hill, Hollinger, Hu, John Davey, Koelle, Ladds, Langer, Li, Lopez-Bernal, Manu Vatish, Milligan, Mittmann, Moore, Neitzel, O'Brien, Park, Phaneuf, Plested, Ross, Saitoh, Sanborn, Sevasti Zervou, Snabaitis, Snow, Steven Thornton, Suarez, Tamirisa, Tang, Tinker, Tribe, Wang, Willars, Xie, Xu, Zeng   +52 more
core   +1 more source

Tubulin Folding Cofactors as GTPase-activating Proteins

Journal of Biological Chemistry, 1999
In vivo, many proteins must interact with molecular chaperones to attain their native conformation. In the case of tubulin, newly synthesized α- and β-subunits are partially folded by cytosolic chaperonin, a double-toroidal ATPase with homologs in all ...
G. Tian, Arunashree Bhamidipati, N. Cowan, S. Lewis   +3 more
semanticscholar   +1 more source