Results 121 to 130 of about 1,011,564 (289)

Akt/AS160 Signaling Pathway Inhibition Impairs Infection by Decreasing Rab14-Controlled Sphingolipids Delivery to Chlamydial Inclusions

Frontiers in Microbiology, 2019
Chlamydia trachomatis, an obligate intracellular bacterium, intercepts different trafficking pathways of the host cell to acquire essential lipids for its survival and replication, particularly from the Golgi apparatus via a Rab14-mediated transport ...
Anahí Capmany, Anahí Capmany, Julián Gambarte Tudela, Julián Gambarte Tudela, Mariano Alonso Bivou, Mariano Alonso Bivou, María T. Damiani, María T. Damiani   +7 more
doaj   +1 more source

RGS9-1 is required for normal inactivation of mouse cone phototransduction [PDF]

, 2001
Purpose: To test the hypothesis that Regulator of G-protein Signaling 9 (RGS9-1) is necessary for the normal inactivation of retinal cones. Methods: Mice having the gene RGS9-1 inactivated in both alleles (RGS9-1 -/-) were tested between the ages 8-10 ...
Chen, C.-K., Lyubarsky, A. L., Naarendorp, F., Pugh, E. N., Jr., Simon, M. I., Wensel, T., Zhang, X.   +6 more
core  

Substrate binding disrupts dimerization and induces nucleotide exchange of the chloroplast GTPase Toc33

, 2011
GTPases act as molecular switches to control many cellular processes, including signalling, protein translation and targeting. Switch activity can be regulated by external effector proteins or intrinsic properties, such as dimerization.
Anja Höfle, Aronsson, Becker, Bos, Bourne, Chen, Chen, Danny J. Schnell, Egea, Enrico Schleiff, Fei Wang, Gasper, Ingmundson, Irmgard Sinning, Ivo Tews, Jarvis, Jelic, Jelic, Kessler, Kikuchi, Koenig, Koenig, Kouranov, Lee, Machner, Maik S. Sommer, Meyer, Mislav Oreb, Neher, Oreb, Oreb, Patrick Koenig, Rapoport, Reddick, Scheffzek, Schleiff, Schleiff, Schleiff, Schnell, Sommer, Sun, Sveshnikova, Weibel, Wickner, Yeh, Zheng   +45 more
core   +3 more sources

Electrophysiology of glioma: a Rho GTPase-activating protein reduces tumor growth and spares neuron structure and function [PDF]

, 2016
Background. Glioblastomas are the most aggressive type of brain tumor. A successful treatment should aim at halting tumor growth and protecting neuronal cells to prevent functional deficits and cognitive deterioration.
Ammassari-Teule, M, Baroncelli, L, Caleo, M, Costa, M, de Graaf, El, Fabbri, A, Fiorentini, C, Mcdonnell, L, Middei, S, Olimpico, F, Schmidt, G, Vannini, E   +11 more
core   +1 more source

Epsin N-terminal homology domains perform an essential function regulating Cdc42 through binding Cdc42 GTPase-activating proteins.

Proceedings of the National Academy of Sciences of the United States of America, 2006
Epsins are endocytic proteins with a structured epsin N-terminal homology (ENTH) domain that binds phosphoinositides and a poorly structured C-terminal region that interacts with ubiquitin and endocytic machinery, including clathrin and endocytic ...
R. Aguilar, S. A. Longhi, J. Shaw, L. Yeh, Sean Kim, A. Schön, E. Freire, A. Hsu, W. K. Mccormick, H. Watson, B. Wendland   +10 more
semanticscholar   +1 more source

7-Keto-Cholesterol and Cholestan-3beta, 5alpha, 6beta-Triol Induce Eryptosis through Distinct Pathways Leading to NADPH Oxidase and Nitric Oxide Synthase Activation [PDF]

, 2019
BACKGROUND/AIMS: We showed that patho-physiological concentrations of either 7-keto-cholesterol (7-KC), or cholestane-3beta, 5alpha, 6beta-triol (TRIOL) caused the eryptotic death of human red blood cells (RBC), strictly dependent on the early production
Allegra M., Attanzio A., Cilla A., Frazzitta A., Livrea M. A., Tesoriere L.   +5 more
core   +1 more source

ACBD3 Interaction with TBC1 Domain 22 Protein Is Differentially Affected by Enteroviral and Kobuviral 3A Protein Binding

mBio, 2013
Despite wide sequence divergence, multiple picornaviruses use the Golgi adaptor acyl coenzyme A (acyl-CoA) binding domain protein 3 (ACBD3/GCP60) to recruit phosphatidylinositol 4-kinase class III beta (PI4KIIIβ/PI4KB), a factor required for viral ...
Alexander L. Greninger, Giselle M. Knudsen, Miguel Betegon, Alma L. Burlingame, Joseph L. DeRisi   +4 more
doaj   +1 more source

Kinetic and Structural Analysis of the Mg2+ -binding Site of the Guanine Nucleotide-binding Protein p21 H-ras. [PDF]

, 1993
The coordination and binding of the Mg2+ ion in the nucleotide−binding site of p21 have been investigated using site−directed mutagenesis, kinetic methods, and phosphorous NMR.
Borasio, Gian Domenico, Goody, R. S., John, J., Rensland, H., Schlichting, I., Vetter, I., Wittinghofer, A.   +6 more
core  

IQGAP scaffold proteins are the multifunctional regulators of cellular signaling and malignant transformation

Успехи молекулярной онкологии, 2017
Scaffold proteins coordinate the assembling of multicomponent protein complexes and participate in transduction of cellular signals via multiple signaling pathways therefore acting as important regulators of cell properties.
P. A. Skovorodnikova, M. S. Chesnokov, A. A. Budko, I. F. Kustova, N. L. Lazarevich   +4 more
doaj   +1 more source

Mind the GAP: RASA2 and RASA3 GTPase-activating proteins as gatekeepers of T cell activation and adhesion. [PDF]

Trends Immunol, 2023
Johansen KH, Golec DP, Okkenhaug K, Schwartzberg PL.   +3 more
europepmc   +1 more source