Results 181 to 190 of about 1,798,469 (249)

miR‐9 Restricts Insulin Secretion by Targeting Rab34, Which Mediates Lysosomal Degradation of Proinsulin

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Insulin secretion is a complex, vesicular transport process. Rab34 is a key regulator of intracellular vesicle transport; however, its role in insulin secretion has not yet been reported. miRNA‐9 is vital for the development and progression of the diagnosis and treatment of type 2 diabetes. This study aimed to investigate whether miR‐9 targets
Zhen‐Zhen Guo, Ao‐Ying Li, Ting‐Ting Xiang, Zu‐Hao Zhang, Ao Deng, Yang Han   +5 more
wiley   +1 more source

An activating mutation in AGEF-1, a putative Arf GEF, causes yolk extrusion from <i>C. elegans</i> embryos. [PDF]

MicroPubl Biol
FitzPatrick C, Skorobogata O, Fazlollahi AM, Gauthier KD, Rocheleau CE.   +4 more
europepmc   +1 more source

Mass Spectrometry Insights Into Post‐Translational Modifications in Extracellular Vesicles

Mass Spectrometry Reviews, EarlyView.
ABSTRACT Extracellular vesicles (EVs) are membrane‐enclosed structures secreted by virtually all living cells, serving as essential mediators of intercellular communication in both physiological and pathological processes. There is growing interest in their potential applications as biomarkers, therapeutic targets, and drug delivery systems, which ...
Dávid Virág, Krisztián Márk Karvaly, Alexandra Molnár, Mirjam Balbisi, Júlia Németh, Lilla Turiák   +5 more
wiley   +1 more source

Identification of <i>RhoGAP</i> Gene Family in Soybean (<i>Glycine max</i> L.) and Its Role in the Response to <i>Rhizobium</i> Infection. [PDF]

Int J Mol Sci
Qin C, Huang H, Sun Y, Luo R, Zhang X, Su B, Song J.   +6 more
europepmc   +1 more source

Multiomics Insights Into AL Amyloidosis

Medicine Bulletin, EarlyView.
ABSTRACT Light chain amyloidosis is a systemic or localized protein conformational disorder triggered by misfolded immunoglobulin light chains, leading to amyloid fibril deposition. The disease is characterized by multiorgan involvement and delayed diagnosis, contributing to poor prognosis and high mortality rates.
Zixuan Zhang, Ziru Huang, Haoxiang Tang, Xianrun Pan, Rong Wang, Dingding Zhang, Jian Huang   +6 more
wiley   +1 more source

Enzymatic versatility of the salmonella effector SopB enables manipulation of host phosphoinositide signalling. [PDF]

Discov Bact
Jensen RC, Fairn GD.
europepmc   +1 more source

The Arf6 GTPase-activating proteins ARAP2 and ACAP1 define distinct endosomal compartments that regulate integrin α5β1 traffic. [PDF]

J Biol Chem, 2014
Chen PW, Luo R, Jian X, Randazzo PA.
europepmc   +1 more source

Tracking Genetic Parkinson's Disease with Molecular Imaging: A Systematic Review

Movement Disorders Clinical Practice, EarlyView.
Abstract Background Parkinson's disease (PD) is a worldwide, complex neurodegenerative disorder influenced by both genetic and environmental factors. Around 15–20% of PD cases are linked to genetic mutations, providing insights into the disease's pathogenesis.
Chiara Meneghini, Luca Gallo, Arianna Sala, Enza Maria Valente, Micol Avenali, Silvia Paola Caminiti   +5 more
wiley   +1 more source

Analysis of RhoH function in vivo [PDF]

, 2007
Dorn, Tatjana
core   +1 more source

IQGAP Family Proteins in Colorectal Cancer: Molecular Mechanisms and Prognostic Implications. [PDF]

Diagnostics (Basel)
Gunawan CK, Sumarpo A, Raharjo B, Parwati I.   +3 more
europepmc   +1 more source