Results 191 to 200 of about 1,798,469 (249)

Recent Advances in Exosome‐Based Nanodelivery Systems for Traumatic Brain Injury Treatment

Med Research, EarlyView.
An overview of functional modification, therapeutic effects, molecular composition, and delivery strategies for exosomes. ABSTRACT Traumatic brain injury (TBI) is a highly heterogeneous neurological condition with extremely high rates of mortality and disability.
Jue Zhu, Weiquan Liao, Ziqi Lian, Mengdan Zhang, Chenxing Wang, Xingjia Zhu, Lin Zhang, Jian Chen, Zhichao Lu, Peipei Gong   +9 more
wiley   +1 more source

Expanding functions of GIT Arf GTPase-activating proteins, PIX Rho guanine nucleotide exchange factors and GIT-PIX complexes.

J Cell Sci, 2016
Zhou W, Li X, Premont RT.
europepmc   +1 more source

In silico tissue-distribution of human Rho family GTPase activating proteins. [PDF]

Small GTPases, 2013
Csépányi-Kömi R, Sáfár D, Grósz V, Tarján ZL, Ligeti E.   +4 more
europepmc   +1 more source

Aspartic Protease Inhibition Induces Proteomic Remodeling in Paracoccidioides brasiliensis

PROTEOMICS, EarlyView.
ABSTRACT Paracoccidioidomycosis (PCM) is a major systemic mycosis in Latin America caused by Paracoccidioides brasiliensis, yet the contribution of aspartic proteases to fungal physiology and pathogenicity remains poorly understood. Here, we employed data‐independent acquisition (DIA)‐based quantitative proteomics to investigate the impact of pepstatin
Sarah Fernandes Lima, Wilson Dias Segura, Leonardo Brogliato de Moraes, Reinaldo Souza Oliveira, Pedro Henrique Corteletti Manfio, Alison Felipe Alencar Chaves, Wagner Luiz Batista   +6 more
wiley   +1 more source

Implications of Rho GTPase signaling in cancer immunotherapy. [PDF]

Biochem Soc Trans
Cai M, Guo F, Zheng Y.
europepmc   +1 more source

Gene turnover in the common ancestor of all C4 grasses

PLANTS, PEOPLE, PLANET, EarlyView.
Understanding how plants evolve more efficient photosynthesis is important in a warming world where improving crop productivity and resilience is a global priority. By generating the first reference genomes for an early‐diverging group of grasses called the Aristidoideae, we were able to reconstruct the genetic makeup of the last common ancestor of all
Lara Pereira, Ahmed S. Alenazi, Sahr Mian, Ilia J. Leitch, Pascal‐Antoine Christin, Colin P. Osborne, Luke T. Dunning   +6 more
wiley   +1 more source

Comparative proteomics reveals distinct functions and localization of invasive Entamoeba histolytica and non-invasive Entamoeba moshkovskii proteins. [PDF]

Parasit Vectors
Leetachewa S, Khomkhum N, Roytrakul S, Reamtong O, Chavalitshewinkoon-Petmitr P, Moonsom S.   +5 more
europepmc   +1 more source

Evolutionary trade‐offs between beauvericin production and growth define divergent virulence strategies in Beauveria

Pest Management Science, EarlyView.
Two virulence strategies in Beauveria: a growth strategy characterized by rapid within‐host proliferation, and a toxin strategy involving antimicrobial activity and toxicity to insects Abstract BACKGROUND Pathogen virulence is often attributed to toxin production, yet toxins are metabolically costly and may not universally enhance fitness.
Shasha Hu, Lana L B de Carvalho, Ricardo A Polanczyk, Michael J Bidochka   +3 more
wiley   +1 more source

Dual targeting of mitochondrial metabolism and Rho GTPase signaling to suppress cancer metastasis (Review). [PDF]

Oncol Rep
Daher A, Assi Z, Kanaan A, Al Khatib A, El Sibai M.   +4 more
europepmc   +1 more source

Phosphoinositide 3-kinase enables phagocytosis of large particles by terminating actin assembly through Rac/Cdc42 GTPase-activating proteins. [PDF]

Nat Commun, 2015
Schlam D, Bagshaw RD, Freeman SA, Collins RF, Pawson T, Fairn GD, Grinstein S.   +6 more
europepmc   +1 more source