Results 251 to 260 of about 1,011,564 (289)
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Inhibition and Termination of Physiological Responses by GTPase Activating Proteins
Physiological Reviews, 2012Physiological processes are strictly organized in space and time. However, in cell physiology research, more attention is given to the question of space rather than to time. To function as a signal, environmental changes must be restricted in time; they need not only be initiated but also terminated.
Stefan Welti+2 more
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PDGF induction of tyrosine phosphorylation of GTPase activating protein [PDF]
The cascade of biochemical events triggered by growth factors and their receptors is central to understanding normal cell-growth regulation and its subversion in cancer. Ras proteins (p21ras) have been implicated in signal transduction pathways used by several growth factors, including platelet-derived growth factor (PDGF).
Stuart A. Aaronson+5 more
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The GTPase-activating protein Rap1GAP uses a catalytic asparagine
Nature, 2004Rap1 is a Ras-like guanine-nucleotide-binding protein (GNBP) that is involved in a variety of signal-transduction processes. It regulates integrin-mediated cell adhesion and might activate extracellular signal-regulated kinase. Like other Ras-like GNBPs, Rap1 is regulated by guanine-nucleotide-exchange factors (GEFs) and GTPase-activating proteins ...
Ingrid R. Vetter+4 more
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Changing expression of GTPase activating proteins with differentiation in neuroblastoma
Journal of the Neurological Sciences, 1994p21ras is a membrane-associated guanine nucleotide-binding protein with intrinsic GTPase activity. Like other guanine nucleotide-binding proteins p21ras is active when GTP bound and inactive when GDP bound. Phosphorylation of p21ras is regulated by the GTPase activity of type I GAP120 and NF1-GRD.
P.A. Berry, S.A. Burchill, I.J. Lewis
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AGD5 is a GTPase-activating protein at the trans-Golgi network
The Plant Journal, 2010ARF-GTPases are important proteins that control membrane trafficking events. Their activity is largely influenced by the interplay between guanine nucleotide exchange factors (GEFs) and GTPase-activating proteins (GAPs), which facilitate the activation or inactivation of ARF-GTPases, respectively. There are 15 predicted proteins that contain an ARF-GAP
Stefano G.+7 more
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Regulation of the GTPase activity of the ras-related rap2 protein
Biochemical and Biophysical Research Communications, 1992The small GTP-binding protein rap2A exhibits a high level of identity with rap1 and ras proteins (60% and 46%, respectively). Nevertheless, its intrinsic GTPase activity is not stimulated by ras-GAP, and unlike the rap1A protein, it cannot compete with ras proteins for their interaction with ras-GAP.
Isabelle Janoueix-Lerosey+3 more
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Chick kainate binding protein lacks GTPase activity
NeuroReport, 1999Chick kainate binding protein was solubilized from cerebellar membranes and purified (x19) by use of two chromatographic steps. Measurements of [3H]kainate binding and GTPase activity in the different fractions reveal a consistent decrease of GTPase activity as the purification proceeds so that no GTPase is detectable after the final purification step.
Tasca, C.I.+4 more
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Bacterial mimics of eukaryotic GTPase-activating proteins (GAPs)
Trends in Biochemical Sciences, 2003Bacterial GTPase-activating proteins (GAPs) subvert their host's eukaryotic Rho GTPases to their own advantage. Studies of bacterial GAPs extend our understanding of the action of eukaryotic GAPs, provide new tools for studies of cytoskeletal dynamics and offer new targets for anti-bacterial drugs.
Zvi Selinger, Yael Litvak
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p115 Rho GTPase activating protein interacts with MEKK1
Journal of Cellular Physiology, 2002AbstractMammalian MAP/ERK kinase kinase 1 (MEKK1) was identified as a mammalian homolog of Ste11p of the yeast pheromone‐induced mating pathway. Like Ste11p, MEKK1 is a MAP3 kinase linked to at least two MAP kinase cascades and regulatory events that require cytoskeletal reorganization. MEKK1 is activated by molecules that impact cytoskeletal function.
Ewen D. Gallagher+7 more
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The Role of ras GTPase Activating Protein in Human Tumorigenesis [PDF]
Abnormal signal transduction involving activated ras genes plays a major role in the development of a variety of tumors. Ras GTPase-activating protein (rasGAP) is a major contributor to the downregulation of ras by facilitating GTP hydrolysis of activated ras. In addition, GAP participates in the down-stream effector system of the ras signaling pathway.
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