Results 271 to 280 of about 129,543 (335)

The GTPase-activating protein CG42795 is a potent neuronal regulator of ageing in D rosophila melanogaster [PDF]

Gergő Falcsik, Fanni Kersztes, Tihomir Balog, Tibor Kovács   +3 more
openalex   +1 more source

Deciphering the Heterogeneity of Pulmonary Macrophages in Response to Fine Particles

Small, EarlyView.
This study introduces a dual‐labeled gold nanoparticle model to capture particle–responsive cells via integrating fluorescence‐activated cell sorting and single‐cell RNA sequencing. Fourteen macrophage subsets are identified with response and function heterogeneity, among which AMs_3, AMs_7, and recMacs_4 subsets show stronger phagocytic activation ...
Qing'e Shan, Zheng Dong, Ning Li, Zijie Zhou, Jiayu Ren, Wei Liu, Feng Xu, Yu Qi, Juan Ma, Yi Liu, Shuping Zhang, Sijin Liu   +11 more
wiley   +1 more source

Neurodevelopmental disorder mutations in the exchange factor DENN/MADD disrupt activation of Rab GTPases. [PDF]

J Biol Chem
Khan M, Kumar R, Trempe JF, Francis V, Banks E, Ayoubi R, Luna LA, McPherson PS.   +7 more
europepmc   +1 more source

Suppression of the GTPase-activating protein RGS10 increases Rheb-GTP and mTOR signaling in ovarian cancer cells

, 2015
Molly K. Altman, Ali A. Alshamrani, Wei Jia, Há Thi Nguyen, Jada M. Fambrough, Sterling Tran, Mihir B. Patel, Pooya Hoseinzadeh, Aaron M. Beedle, Mandi M. Murph   +9 more
openalex   +1 more source

Proteomic Profiling of Alveolar Macrophages Identifies Loss of Lysosomal Content as an Indicator of Nanofiber‐Induced Frustrated Phagocytosis

Small, EarlyView.
This proteomic study examines how nanofibers affect lung macrophages by analyzing protein changes following exposure to various fibrous materials. Nanofibers triggered the release of inflammatory enzymes, and importantly, lysosomal content release was identified as an early event associated with frustrated phagocytosis. Seventeen sensitive and relevant
Tobias Stobernack, Antje Vennemann, Carla Ribalta, Julia Schendel, Oliver Gräb, Rico Ledwith, Mario Pink, Andrea Haase, Martin Wiemann, Verónica I. Dumit   +9 more
wiley   +1 more source

Mechanisms of mTORC1 and GCN2 amino acid sensing pathways in tumorigenesis and metastatic progression (Review). [PDF]

Int J Mol Med
Zhang C, Han Y, Yao W, Hong Q, Chen N.
europepmc   +1 more source

Evolution of Tre-2/Bub2/Cdc16 (TBC) Rab GTPase-activating proteins. [PDF]

Mol Biol Cell, 2013
Gabernet-Castello C, O'Reilly AJ, Dacks JB, Field MC.   +3 more
europepmc   +1 more source

Ras GTPase-Activating-Like Protein IQGAP2 [PDF]

, 2020
openaire   +1 more source

Single‐cell RNA sequencing revealed the T‐cell heterogeneity and exhaustion subsets of Helicobacter pylori‐induced gastritis‐to‐cancer transformation

VIEW, EarlyView.
H. pylori infection is a major cause of stomach cancer, but its effect on immune cells in tumors is unclear. Using single‐cell sequencing, we mapped the stomach tumor environment and discovered a specific exhausted T‐cell subtype, marked by the FYB1 gene, that is abundant in H. pylori‐positive tumors and linked to patient prognosis. Our findings reveal
Yanhui Yang, Yanxia Liu, Xiaole Guo, Zhaorun Li, Ziyu Liu, Shuming Zhang, Yuma Yang, Jun Liu, Shoucheng Ma, Linke Ma, Xianmei Chen, Xue Li, Yuanyuan Tang, Xiaoling Ding, Xiaofei Li, Qian Hao, Yanjie You, Tingting Yang, Qingrui Li, Xue Zhang, Sihan Zhang, Hengjun Gao, Shengjuan Hu   +22 more
wiley   +1 more source

The GTPase κB-Ras is an essential subunit of the RalGAP tumor suppressor complex. [PDF]

J Biol Chem
Rasche R, Apken LH, Titze S, Michalke E, Singh RK, Oeckinghaus A, Kümmel D.   +6 more
europepmc   +1 more source