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GTPase activity of bacteriophage T4 sheath protein
Journal of Molecular Biology, 1992We show by nuclear magnetic resonance studies that, following GTP hydrolysis during phage T4 sheath contraction, GDP remains bound to the sheath protein (gp18), whereas orthophosphate is released. gp18 in the contracted state has GTPase activity and can hydrolyse exogenous GTP; the reaction is calcium-dependent and displays high substrate specificity ...
I I, Serysheva +3 more
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Rho GTPase-activating proteins in cell regulation
Trends in Cell Biology, 2003Rho family small GTPases serve as molecular switches involved in the regulation of diverse cellular functions including various cytoskeleton-related events and gene transcription. The Rho GTPase-activating proteins (RhoGAPs) are one of the major classes of regulators of Rho GTPases found in all eukaryotes that are crucial in cell cytoskeletal ...
Sun Young, Moon, Yi, Zheng
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Molecular and Cellular Neuroscience, 2017
The Rho family of small GTPases was considered as molecular switches in regulating multiple cellular events, including cytoskeleton reorganization. The Rho GTPase-activating proteins (RhoGAPs) are one of the major families of Rho GTPase regulators.
Guo-Hui, Huang +3 more
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The Rho family of small GTPases was considered as molecular switches in regulating multiple cellular events, including cytoskeleton reorganization. The Rho GTPase-activating proteins (RhoGAPs) are one of the major families of Rho GTPase regulators.
Guo-Hui, Huang +3 more
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Rho GTPase Activating Proteins in Cancer Phenotypes
Current Protein & Peptide Science, 2006Rho proteins belong to the Ras superfamily of small GTPases and function as binary switches that shuttle between active and inactive states based on the nature of bound guanine nucleotide. Three sets of regulatory proteins, namely, guanine dissociation inhibitors, guanine exchange factors, and GTPase activating proteins (GAPs) control the balance ...
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Rho GTPase-Activating Proteins in Cancer
2009Rho GTPases are involved in a variety of cellular functions and require strict regulation to insure proper signaling. As negative regulators of the Rho proteins, Rho GTPase-activating proteins (GAPs) also play critical roles in cytoskeleton regulation, cell-cycle control, gene expression, and normal development.
Matthew W. Grogg, Yi Zheng
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