Results 31 to 40 of about 13,809 (125)
Virtual Identification of Essential Proteins Within the Protein Interaction Network of Yeast [PDF]
, 2005 Topological analysis of large scale protein-protein interaction networks (PINs) is important for understanding the organisational and functional principles of individual proteins. The number of interactions that a protein has in a PIN has been observed to be correlated with its indispensability.
arxiv +1 more source
Discover OncologyRectal adenocarcinoma (READ) is a common malignant tumor of the digestive tract. Growing studies have confirmed Ras GTPase-activating proteins are involved in the progression of several tumors.
Yun Xiao +7 more
doaj +1 more source
Length, Protein-Protein Interactions, and Complexity [PDF]
, 2004 The evolutionary reason for the increase in gene length from archaea to prokaryotes to eukaryotes observed in large scale genome sequencing efforts has been unclear. We propose here that the increasing complexity of protein-protein interactions has driven the selection of longer proteins, as longer proteins are more able to distinguish among a larger ...
arxiv +1 more source
The Regulation of Rab GTPases by Phosphorylation
Biomolecules, 2021 Rab proteins are small GTPases that act as molecular switches for intracellular vesicle trafficking. Although their function is mainly regulated by regulatory proteins such as GTPase-activating proteins and guanine nucleotide exchange factors, recent ...
Lejia Xu +4 more
doaj +1 more source
ProNet DB: A proteome-wise database for protein surface property representations and RNA-binding profiles [PDF]
arXiv, 2022 The rapid growth in the number of experimental and predicted protein structures and more complicated protein structures challenge users in computational biology for utilizing the structural information and protein surface property representation. Recently, AlphaFold2 released the comprehensive proteome of various species, and protein surface property ...
arxiv
Potassium acts as a GTPase-activating element on each nucleotide-binding domain of the essential Bacillus subtilis EngA. [PDF]
PLoS ONE, 2012 EngA proteins form a unique family of bacterial GTPases with two GTP-binding domains in tandem, namely GD1 and GD2, followed by a KH (K-homology) domain.
Anne-Emmanuelle Foucher +4 more
doaj +1 more source
Cells, 2022 Type 2 diabetes mellitus (T2DM) is a complex and heterogeneous disease that primarily results from impaired insulin secretion or insulin resistance (IR). G protein-coupled receptors (GPCRs) are proposed as therapeutic targets for T2DM.
Xiaohong Zhang +5 more
doaj +1 more source
A Point Mutation in p190A RhoGAP Affects Ciliogenesis and Leads to Glomerulocystic Kidney Defects. [PDF]
PLoS Genetics, 2016 Rho family GTPases act as molecular switches regulating actin cytoskeleton dynamics. Attenuation of their signaling capacity is provided by GTPase-activating proteins (GAPs), including p190A, that promote the intrinsic GTPase activity of Rho proteins. In
Katherine Stewart +16 more
doaj +1 more source
Kinetics and Thermodynamics of Membrane Protein Folding [PDF]
Biomolecules 2014, 4(1), 354-373, 2014 Understanding protein folding has been one of the great challenges in biochemistry and molecular biophysics. Over the past 50 years, many thermodynamic and kinetic studies have been performed addressing the stability of globular proteins. In comparison, advances in the membrane protein folding field lag far behind. Although membrane proteins constitute
arxiv +1 more source
International Journal of Hepatology, 2012 IQ motif-containing GTPase-activating proteins IQGAP1 and IQGAP2 are highly homologous multidomain scaffolding proteins. Their major function consists of integration of Rho GTPase and Ca2+/calmodulin signals with cell adhesive and cytoskeletal ...
Valentina A. Schmidt
doaj +1 more source