Results 201 to 210 of about 322,041 (407)
cGAS Inhibits ALDH2 to Suppress Lipid Droplet Function and Regulate MASLD Progression
Advanced Science, EarlyView.cGAS is a cytosolic DNA sensor known for innate immune defense. cGAS binds and suppresses ALDH2 are showed, limiting acetyl‐CoA production. cGAS loss activates ALDH2, promoting histone acetylation, lipogenesis, and lipid droplets accumulation. cGas‐/‐ mice on a high‐fat diet show signs of worsened MASLD.
Ying Wang +14 more
wiley +1 more source
Antibiotic interactions at the GTPase-associated centre within Escherichia coli 23S rRNA.
, 1989 Jan Egebjerg +2 more
openalex +1 more source
Efficient coupling with phosphatidylinositol 3-kinase, but not phospholipase C gamma or GTPase-activating protein, distinguishes ErbB-3 signaling from that of other ErbB/EGFR family members. [PDF]
, 1994 Paolo Fedi +3 more
openalex +1 more source
Advanced Science, EarlyView.Schizophrenia (SCZ) is linked to synaptic structural deficits driven by dysregulated noncoding RNAs. Using the novel ceRNAxis pipeline, THUMPD3‐AS1/miR‐485‐5p/ARHGAP8 is identified as a key regulator of actin cytoskeletal remodeling through noncanonical RhoB/C‐ROCK2 signaling. Modulating this axis ameliorates SCZ‐like phenotypes in mice and aligns with
Xiaojuan Gong +9 more
wiley +1 more source
The carboxy-terminal catalytic domain of the GTPase-activating protein inhibits nuclear signal transduction and morphological transformation mediated by the CSF-1 receptor. [PDF]
, 1991 Donna M. Bortner +3 more
openalex +1 more source
Functional specialization of the yeast Rho1 GTP exchange factors [PDF]
, 2012 Rho GTPases are regulated in complex spatiotemporal patterns that may be dependent, in part at least, on the multiplicity of their GTP exchange factors (GEFs).
Cundell, M. +6 more
core
Rho GTPase complementation underlies BDNF-dependent homo- and heterosynaptic plasticity
Nature, 2016 N. Hedrick +5 more
semanticscholar +1 more source