Results 61 to 70 of about 61,842 (198)
Mitofusin 1 Drives Preimplantation Development by Enhancing Chromatin Incorporation of Histone H3.3
Advanced Science, EarlyView.MFN1 exerts its function partially through histone H3.3 in early embryos. MFN1 colocalizes with PADI6, and its deficiency results in compromised cytoplasmic lattices and ribosomal subunits, leading to declined H3.3 protein level. This, in turn, hinders the incorporation of H3.3 into the embryonic genome, thereby causing failure of male pronucleus ...
Xiao‐yan Shi +9 more
wiley +1 more source
Food Science &Nutrition, Volume 11, Issue 1, Page 39-56, January 2023., 2023 Rutin is a flavonoid present in many plant species. Because of its antioxidant, anti‐inflammatory, and anti‐apoptotic properties, rutin is of interest for its potential protective effects against toxic agents. Rutin has potential therapeutic effectiveness against several toxicants, and its beneficial effects are more than likely mediated by its ...
Sohrab Rahmani +4 more
wiley +1 more source
RAB3B Dictates mTORC1/S6 Signaling in Chordoma and Predicts Response to mTORC1‐Targeted Therapy
Advanced Science, EarlyView.RAB3B is unveiled as a prominent oncogenic regulator in chordoma, which can block the DUSP12‐mediated dephosphorylation of p‐S6 (S235/236). The combination of RAB3B and p‐S6 indicates a good prognostic value and predicts mTORC1 inhibitors response for chordoma patients.
Jianxuan Gao +15 more
wiley +1 more source
Science Signaling, 2013 A complex that inactivates a GTPase keeps the TORC1 pathway in check in times of amino acid deprivation. Suppressing Activity During Deprivation The target of rapamycin complex 1 (TORC1) in yeast couples nutrient availability to signaling pathways that ...
Nicolas Panchaud +2 more
semanticscholar +1 more source
Advanced Science, EarlyView.This work proposes a new mechanism for the regulation of LDs metabolism by ANXA7/PPARγ. ANXA7 can interact with PPARγ to promote its stability. ANXA7 activation promotes PPARγ nuclear translocation, thus promoting LDs formation and interaction with mitochondria by promoting PLIN5 expression.
Lu Chen +6 more
wiley +1 more source
Hepatology, EarlyView., 2022 KAT7‐acetylated and cytoplasm‐translocated G‐protein GαS enhances IL‐6 effect and drives HCC progenitor cell progression. Abstract Background and Aims Hepatocarcinogenesis goes through HCC progenitor cells (HcPCs) to fully established HCC, and the mechanisms driving the development of HcPCs are still largely unknown.
Ye Zhou +15 more
wiley +1 more source
Proceedings of the National Academy of Sciences of the United States of America, 2014 Significance Mutations in the gene encoding for leucine-rich-repeat kinase 2 (LRRK2) are a common cause of Parkinson disease (PD). To understand how LRRK2 causes PD, we need to understand its normal functions and how they are altered by disease-causing ...
J. Liao +14 more
semanticscholar +1 more source
Advanced Science, EarlyView.Here a transcranial photo‐biomodulation approach is developed using near‐infrared (NIR) laser on hippocampus of mice, revealing significant improvements in learning and memory ability of mice under normal and disease conditions. The improvement results from the high‐density cell‐induced NIR local energy deposition, neuronal activation, and axonogenesis
Wei‐Tong Pan +6 more
wiley +1 more source
Macrophage‐derived MLKL in alcohol‐associated liver disease: Regulation of phagocytosis
Hepatology, EarlyView., 2022 EtOH causes leaky gut allowing bacteria and PAMPs into the liver, resulting in hepatic inflammation and injury. We demonstrate that LPS induces STAT1‐mediated expression and phosphorylation of MLKL in macrophages and identify a novel function that myeloid MLKL translocates to phagosomes and lysosomes and regulates phagocytosis, which contributes to the
Xiaoqin Wu +16 more
wiley +1 more source
Advanced Science, EarlyView.The FGF13 level is significantly downregulated in premature aging murine hearts subject to D‐galactose and Doxorubicin. FGF13 overexpression and deficiency exacerbated and alleviated Doxorubicin/D‐galactose‐induced myocardial aging characteristics and functional impairment, respectively.
Enzhao Shen +15 more
wiley +1 more source