Results 11 to 20 of about 6,079 (194)

Unloading-Induced Skeletal Interoception Alters Hypothalamic Signaling to Promote Bone Loss and Fat Metabolism. [PDF]

Adv Sci (Weinh), 2023
During unloading, PGE2/EP4 ascending signal increases the expression of both sympathetic tone and NPY level in the hypothalamus. The elevated NE leads to bone loss while increased hypothalamic NPY acts as neuronal endocrine factor for the impaired metabolism.
Guo Q, Chen N, Patel K, Wan M, Zheng J, Cao X.   +5 more
europepmc   +2 more sources

Sympathetic Innervation Regulates Osteocyte-Mediated Cortical Bone Resorption during Lactation. [PDF]

Adv Sci (Weinh), 2023
During lactation, norepinephrine (NE) levels increase in cortical bone. In response, osteocytes increase Ca2+ signaling to promote the secretion of bone resorptive extracellular vesicles and cathepsin K (Ctsk) to degrade the perilacunar area bone matrix.
Guo Q, Chen N, Qian C, Qi C, Noller K, Wan M, Liu X, Zhang W, Cahan P, Cao X.   +9 more
europepmc   +2 more sources

Recent Advances in Renal Denervation Therapy and Novel Applications of High-Intensity Focused Ultrasound. [PDF]

Cardiovasc Ther
Hypertension constitutes a major risk factor for cardiovascular diseases. Globally, the management and control of hypertension remain suboptimal. At present, pharmacological intervention is a critical strategy for patients with hypertension to achieve blood pressure regulation.
Wang J, Ma Y, Li X.
europepmc   +2 more sources

Effects of Different Doses of Pralidoxime Administered During Cardiopulmonary Resuscitation and the Role of α‐Adrenergic Receptors in Its Pressor Action

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2020
Background We previously reported that pralidoxime facilitated restoration of spontaneous circulation by potentiating the pressor effect of epinephrine. We determined the optimal dose of pralidoxime during cardiopulmonary resuscitation and evaluated the ...
Yong Hun Jung, Najmiddin Mamadjonov, Hyoung Youn Lee, Kyung Woon Jeung, Byung Kook Lee, Chun Song Youn, Tag Heo, Yong Il Min   +7 more
doaj   +1 more source

The role of the autonomic nervous system in stress cardiomyopathy

Бюллетень сибирской медицины, 2021
Aim. To identify the role of the autonomic nervous system in stress cardiomyopathy in an experimental model of Takotsubo syndrome.Materials and methods. The study was carried out on 120 female Wistar rats.
E. S. Prokudina, L. N. Maslov, N. V. Naryzhnaya, B. K. Kurbatov, A. V. Mukhomedzyanov, V. V. Shipulin, A. V. Krylatov, S. Yu. Tsibulnikov, N. S. Voronkov   +8 more
doaj   +1 more source

Electrical field stimulation-induced contractions on Pantherophis guttatus corpora cavernosa and aortae. [PDF]

PLoS ONE, 2018
A tetrodotoxin (TTX)-resistant mechanism is responsible for the electrical field stimulation (EFS)-induced contractions and relaxations of Crotalus durissus terrificus corpora cavernosa.
Rafael Campos, Fabíola Z Mónica, Alberto Fernando Oliveira Justo, José Carlos Cogo, Edvana de Toledo Oliveira, Ronilson Agnaldo Moreno, Edson Antunes, Gilberto De Nucci   +7 more
doaj   +1 more source

Tetrodotoxin-insensitive electrical field stimulation-induced contractions on Crotalus durissus terrificus corpus cavernosum. [PDF]

PLoS ONE, 2017
Reptiles are the first amniotes to develop an intromitent penis, however until now the mechanisms involved in the electrical field stimulation-induced contraction on corpora cavernosa isolated from Crotalus durissus terrificus were not investigated ...
Rafael Campos, Fabíola Z Mónica, Renata Lopes Rodrigues, Julio Alejandro Rojas-Moscoso, Ronilson Agnaldo Moreno, José Carlos Cogo, Marco Antonio de Oliveira, Edson Antunes, Gilberto De Nucci   +8 more
doaj   +1 more source

Oxidized soluble guanylyl cyclase causes erectile dysfunction in alcoholic mice

British Journal of Pharmacology, Volume 180, Issue 18, Page 2361-2376, September 2023., 2023
Background and purpose Alcohol abuse has been associated with erectile dysfunction (ED), but the implicated molecular mechanisms are unresolved. This study analyses the role of alterations in soluble guanylyl cyclase (sGC) in ED. Experimental approach ED was analysed in adult male C57BL/6J mice subjected to the Chronic Intermittent Ethanol (CIE ...
Miguel A. Olivencia, Leticia Gil de Biedma‐Elduayen, Pablo Giménez‐Gómez, Bianca Barreira, Argentina Fernández, Javier Angulo, Maria Isabel Colado, Esther O'Shea, Francisco Perez‐Vizcaino   +8 more
wiley   +1 more source

Electrical field-induced contractions on Crotalus durissus terrificus and Bothrops jararaca aortae are caused by endothelium-derived catecholamine. [PDF]

PLoS ONE, 2018
Endothelium is the main source of catecholamine release in the electrical-field stimulation (EFS)-induced aortic contractions of the non- venomous snake Panterophis guttatus.
Rafael Campos, Alberto Fernando Oliveira Justo, Fabíola Z Mónica, José Carlos Cogo, Ronilson Agnaldo Moreno, Valéria Barbosa de Souza, Andre Almeida Schenka, Gilberto De Nucci   +7 more
doaj   +1 more source

Dietary Supplementation with the Probiotic SF68 Reinforces Intestinal Epithelial Barrier in Obese Mice by Improving Butyrate Bioavailability

Molecular Nutrition &Food Research, Volume 67, Issue 13, July 2023., 2023
Modifications in short‐chain fatty acids are among the factors altering the intestinal epithelial barrier integrity and eliciting the onset of a meta‐inflammation observed in obesity. The study evaluates the efficacy of Enterococcus faecium (SF68) on intestinal inflammation and gut barrier alterations in a model of diet‐induced obesity. Supplementation
Laura Benvenuti, Vanessa D'Antongiovanni, Carolina Pellegrini, Matteo Fornai, Nunzia Bernardini, Chiara Ippolito, Cristina Segnani, Clelia Di Salvo, Rocchina Colucci, Alma Martelli, Lorenzo Flori, Vincenzo Calderone, Gianfranca Carta, Emilia Ghelardi, Marco Calvigioni, Adelaide Panattoni, Raffaella Coppolecchia, Achille Arini, Luca Antonioli   +18 more
wiley   +1 more source