Guanethidine Restores Tetracycline Sensitivity in Multidrug-Resistant Escherichia coli Carrying tetA Gene [PDF]
AntibioticsThe worrying issue of antibiotic resistance in pathogenic bacteria is aggravated by the scarcity of novel therapeutic agents. Antibiotic adjuvants offer a promising solution due to their cost-effectiveness and high efficacy in addressing this issue, such
Xiaoou Zhao +12 more
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Guanethidine Enhances the Antibacterial Activity of Rifampicin Against Multidrug-Resistant Bacteria [PDF]
MicroorganismsThe escalating global threat of antibiotic resistance necessitates innovative strategies, such as the combination of antibiotics with adjuvants. Monotherapy with rifampicin is more likely to induce resistance in pathogens compared to other antibiotics ...
Xiaoou Zhao +9 more
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The effect of local sympatholysis on bone-tendon interface healing in a murine rotator cuff repair model [PDF]
Journal of Orthopaedic Translation, 2023 Background: Although neuroregulation plays an important role in tissue healing, the key neuroregulatory pathways and related neurotransmitters involved in bone-tendon interface (BTI) healing are still unknown.
Tingmo Huang +7 more
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Sympathectomy Effects on Intra-Abdominal Organ Catecholamine Levels in a Streptozotocin-Induced Diabetic Rat Model [PDF]
Life, 2022 Diabetes mellitus (DM) is a metabolic disorder whose prevalence has continuously increased worldwide and is associated with dysfunction of the autonomic nervous system and, in particular, that of the sympathetic nervous system (SNS).
Angélica Pérez-Juárez +2 more
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Comprehensive analysis of SLC43A2 on the tumor immune microenvironment and prognosis of liver hepatocellular carcinoma [PDF]
Frontiers in Genetics, 2022 Background: Tumor cells outcompete T cells for methionine via overexpressing SLC43A2, causing T cells exhaustion. We explored the influence of SLC43A2 on tumor immune microenvironment (TIME), immune-related genes (IRGs) and the prognosis of liver ...
Yan Liao +11 more
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Effects of GS-967, GS-6615 and ranolazine on the responses of the rabbit aorta to adrenergic nerve stimulation [PDF]
Frontiers in PhysiologyIntroductionIn the present study we aim to determine the effects of different inhibitors of the late sodium current (INa,late) on vascular responses to adrenergic stimuli, both endogenous and exogenous.MethodsThe study was performed using specific ...
Maria Dolores Mauricio +5 more
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Bolus Injection of Liraglutide Raises Plasma Glucose in Normal Rats by Activating Glucagon-like Peptide 1 Receptor in the Brain [PDF]
Pharmaceuticals, 2022 Diabetes is commonly treated with glucagon-like peptide-1 receptor (GLP-1R) agonists including liraglutide and others. However, liraglutide was found to raise plasma glucose levels in normal rats.
Chia-Chen Hsu +4 more
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Deep learning-based discovery of compounds for blood pressure lowering effects [PDF]
Scientific ReportsThe hypotensive side effects caused by drugs during their use have been a vexing issue. Recent studies have found that deep learning can effectively predict the biological activity of compounds by mining patterns and rules in the data, providing a ...
Rongzhen Li +4 more
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Unloading-Induced Skeletal Interoception Alters Hypothalamic Signaling to Promote Bone Loss and Fat Metabolism. [PDF]
Adv Sci (Weinh), 2023 During unloading, PGE2/EP4 ascending signal increases the expression of both sympathetic tone and NPY level in the hypothalamus. The elevated NE leads to bone loss while increased hypothalamic NPY acts as neuronal endocrine factor for the impaired metabolism.
Guo Q +5 more
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Comparative evaluation of pilocarpine 2% and combined guanethidine 1% & adrenaline 0.5% in the treatment of chronic simple glaucoma [PDF]
Indian Journal of Ophthalmology, 1987 This paper reports on the results of a comparative study between pilocarpine 2%, Guanethidine 1 % &adrenaline 0.5% combination over a 6 months period with each formulation. The guanethidine/-adrenaline formulation was found to
Mehrotra A, Jain B, Anand G
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