Raised tone reveals ATP as a sympathetic neurotransmitter in the porcine mesenteric arterial bed [PDF]
, 2014 The relative importance of ATP as a functional sympathetic neurotransmitter in blood vessels has been shown to be increased when the level of preexisting vascular tone or pressure is increased, in studies carried out in rat mesenteric arteries.
A Saul +34 more
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Virtual Screen for Repurposing of Drugs for Candidate Influenza a M2 Ion-Channel Inhibitors
Frontiers in Cellular and Infection Microbiology, 2019 Influenza A virus (IAV) matrix protein 2 (M2), an ion channel, is crucial for virus infection, and therefore, an important anti-influenza drug target.
Draginja Radosevic +10 more
doaj +1 more source
Vasodilator Action of Guanethidine [PDF]
Circulation Research, 1962 The cardiovascular effects of intravenous guanethidine were measured in animals treated with reserpine. The action of intraarterial guanethidine was studied also in perfused forelegs of dogs. The following conclusions were reached: 1. There was no significant increase in cardiac output, heart rate, or systemic arterial pressure following ...
F M, ABBOUD, J W, ECKSTEIN
openaire +2 more sources
Synthesis and pharmacology of alkanediguanidinium compounds that block the neuronal nicotinic acetylcholine receptor [PDF]
, 1996 Taking as models the polyamine toxin fraction FTX from the funnel-web spider venom, and the guanidinium moiety of guanethidine, a series of azaalkane-1,omega-diguanidinium salts were obtained.
Cueto, Sénida +6 more
core +3 more sources
The effects of superior ovarian nerve sectioning on ovulation in the guinea pig [PDF]
, 2003 The effects on spontaneous ovulation associated with the unilateral or bilateral sectioning of the superior ovarian nerves (SON) were analyzed in guinea pigs at different time intervals of the estrous cycle.
F Luna +5 more
core +1 more source
cAMP catalyzing phosphodiesterases control cholinergic muscular activity but their inhibition does not enhance 5-HT4 receptor-mediated facilitation of cholinergic contractions in the murine gastrointestinal tract [PDF]
, 2018 Background: As the signal transduction of 5-HT4 receptors on cholinergic neurons innervating smooth muscle is controlled by phosphodiesterase (PDE) 4 in porcine stomach and colon, and human large intestine, the in vivo gastroprokinetic effects of a 5-HT4
Lefebvre, Romain, Pauwelyn, Vicky
core +7 more sources
The arteriolar vasodilatation model of vibrio cholerae induced diarrhoeal disease [PDF]
, 2018 Secretory diarrhoeal disease caused by enterotoxins produced by pathogenic bacteria is characterised by severe fluid loss into the intestine. A prevalent explanation for such high rates of loss, such as occur in episodes of cholera, is that intestinal ...
Lucas, Michael
core +1 more source
Mediators of Inflammation, 1997 It has been suggested that the supernatant of LPSstimulated macrophages (macrophage nociceptive factor, MNF) promotes nociception in mice. Intraperitoneal administration of MNF induced dose-related writhing, which reached a plateau between 18 and 26 min ...
S. M. Thomazzi +4 more
doaj +1 more source
Journal of Pharmacological Sciences, 2012 The present study investigated whether histamine was taken up by perivascular adrenergic nerves and released by periarterial nerve stimulation (PNS) to induce vascular responses.
Yuto Haruki +6 more
doaj +1 more source
Outcome measures for complex regional pain syndrome type I: an overview in the context of the international classification of impairments, disabilities and handicaps. [PDF]
, 2000 PURPOSE: To determine the availability of relevant and objective outcome measures concerning complex regional pain syndrome type I (CRPS I) for rehabilitation medicine.
Bussmann, J.B.J. (Hans) +2 more
core +1 more source