Results 71 to 80 of about 4,383 (215)
British Journal of Pharmacology, Volume 182, Issue 8, Page 1803-1822, April 2025.Abstract Background and Purpose Inflammatory bowel disease (IBD) patients display genetic polymorphisms in toll‐like receptor 4 (TLR4) genes, contributing to dysregulate enteric nervous system (ENS) circuits with increased levels of 5‐HT and alteration of the neuroimmune crosstalk.
Sofia Faggin +12 more
wiley +1 more source
Acute hemodynamic responses to intravenous and intra-arterial guanethidine [PDF]
, 1961 Intravenous administration of guanethidine to dogs causes an abrupt fall in systemic arterial pressure which is followed by a sustained increase. These studies were made to determine the nature of this biphasic response.
Francois M. Abboud +2 more
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Role of the calcium‐sensing receptor in regulating vascular function
Journal of Cell Communication and Signaling, Volume 19, Issue 1, March 2025.Representation of the role of the CaSR in the vasculature shows that a rise in extracellular Ca2+ concentration ([Ca2+]o) stimulates the CaSR expressed at the plasma membrane of perivascular sensory nerves, VECs, and VSMCs, which leads to the release of vasodilator substances (e.g., calcitonin‐related gene‐related peptide (CGRP), substance P (Sub P ...
Anthony P. Albert, Harry Z.E. Greenberg
wiley +1 more source
Inhibition of Gastric Acid Secretion by Unfractionated and Low Molecular Weight Heparins in the Rat
The Scientific World Journal, 2006 The majority of patients receiving heparin preparations are at stress, which is a risk factor for the development of gastric erosions. Our aim was to examine the effect of unfractionated heparin (UFH) and low molecular weight heparins (LMWHs) on gastric ...
Omar M.E. Abdel Salam +2 more
doaj +1 more source
Activation of neural cholecystokinin-1 receptors induces relaxation of the isolated rat duodenum which is reduced by nitric oxide synthase inhibitors
Brazilian Journal of Medical and Biological Research, 2006 Cholecystokinin (CCK) influences gastrointestinal motility, by acting on central and peripheral receptors. The aim of the present study was to determine whether CCK has any effect on isolated duodenum longitudinal muscle activity and to characterize the ...
S.R. Martins +2 more
doaj +1 more source
Cellular effects of chronic guanethidine administration [PDF]
, 1976 Typescript (photocopy)Thesis (PhD) -- University of Melbourne, Faculty of Science, 1977Includes bibliographical referencesThe effects of chronic guanethidine administration on the peripheral and central monoaminergic neurons of the rat and on the ...
Evans, Barbara Kay
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Mitochondrial oxidative energy metabolism in guanethidine-induced sympathectomized ducklings [PDF]
, 2014 International audienceHere we investigate the possible involvement of the sympathetic nervous system in the respiratory properties of intermyofibrillar and subsarcolemmal mitochondrial populations from heart and gastrocnemius muscles.
Roussel, Damien +3 more
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Endothelium-Derived Relaxing Factor–Mediated Vasodilation in Mouse Mesenteric Vascular Beds
Journal of Pharmacological Sciences, 2012 The endothelium in rat mesenteric vascular beds has been demonstrated to regulate vascular tone by releasing mainly endothelium-derived hyperpolarizing factor (EDHF), which is involved in the activation of K+ channels and gap-junctions.
Hiroki Fujiwara +7 more
doaj +1 more source
Neurogastroenterology &Motility, Volume 36, Issue 11, November 2024.The natural aging process can reduce lower bowel motility, leading to an increased incidence of chronic constipation. Aging reduces tachykinin signaling in the distal colon reducing colonic motility. Medicines that increase tachykinin signaling could be useful for treating chronic constipation in older people.
Mark S. Yeoman +6 more
wiley +1 more source
An assessment of the cardiovascular sympathectomy induced by guanethidine [PDF]
, 1976 Guanethidine treatment of rats (30 mg kg−1, i.p. daily for 6 weeks) produced a profound reduction in the catecholamine present (as indicated by fluorescence histochemistry and catecholamine determinations) in tissues taken from the cardiovascular system,
R C Hall, T H Blythe, I E Hughes
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