Results 81 to 90 of about 4,383 (215)

Characterization of nerve-induced relaxation of gastrointestinal sphincteric smooth muscle in a South American opossum (Didelphis albiventris)

open access: yesBrazilian Journal of Medical and Biological Research, 1997
The presence of inhibitory nonadrenergic noncholinergic (NANC) intrinsic innervation of the circular muscle of the gastrointestinal sphincters of the South American (SA) opossum was investigated in vitro.
N.M. Matsuda, R.B. Oliveira, G. Ballejo
doaj   +1 more source

Cardiac Arrhythmias in Pulmonary Arterial Hypertension and Chronic Thromboembolic Pulmonary Hypertension: Mechanistic Insights, Pathophysiology, and Outcomes

open access: yesAnnals of Noninvasive Electrocardiology, Volume 29, Issue 5, September 2024.
This review provides an overview of the latest evidence on this subject, spanning from the molecular mechanisms underlying arrhythmias in the hypertrophied or failing right heart to the clinical aspects of epidemiology, diagnosis, and treatment.
Abdulrahman Abouzaid   +7 more
wiley   +1 more source

Guanethidine-induced sympathectomy in the nude rat [PDF]

open access: yes, 1989
Guanethidine sulphate 40 mg/kg was administered intraperitoneally daily for 14 days to normal Lewis rats and athymic nude rats of a Lewis background (rnu/rnu).
Juul, P, Juul, A, Christensen, H B
core  

Effects of PF-05231023 on heart rate and blood pressure in guanethidine-treated rats. [PDF]

open access: yes, 2018
(A) Representative sections of hematoxylin & eosin (H&E) and tyrosine hydroxylase (TH)-immunostained superior cervical ganglia (SCG) from animals that received PF-05231023 (10 mg/kg IV) 4 months post vehicle (n = 9) or guanethidine (n = 12) treatment ...
Xian Chen (107385)   +7 more
core   +1 more source

Modulation of Noradrenergic Neurotransmission in Isolated Rat Radial Artery

open access: yesJournal of Pharmacological Sciences, 2009
The present study was designed to characterize the neurogenic contraction of rat radial artery. Electrical field stimulation (EFS) evoked frequency-dependent contraction that was abolished by tetrodotoxin (neuronal Na+ channel blocker), guanethidine ...
Ana Cristina Martínez   +6 more
doaj   +1 more source

MECHANISM OF ACTION OF GUANETHIDINE [PDF]

open access: yesBritish Journal of Pharmacology and Chemotherapy, 1962
The early hypotensive action of intravenous guanethidine in rabbits, rats and cats anaesthetized with urethane is reversed after pretreatment with iproniazid. The fall in blood pressure following injection of guanethidine in rabbits is reduced after previous administration of reserpine.
openaire   +2 more sources

The Lower Urinary Tract Science Group—ICI‐RS. 7th June 2023 record of a meeting at Bristol University, UK

open access: yesNeurourology and Urodynamics, Volume 43, Issue 6, Page 1253-1260, August 2024.
Abstract Aims The aim of a preliminary session of the International Continence on Incontinence—Research Society (ICI‐RS) was to provide a forum for an international group of experimental scientists, who are members of ICI‐RS, to explain their on‐going work to fellow laboratory scientists, to obtain feedback about future directions and discuss potential
Christopher Fry
wiley   +1 more source

Delayed sympathetic dependence in the spared nerve injury (SNI) model of neuropathic pain

open access: yesMolecular Pain, 2007
Background Clinical and experimental studies of neuropathic pain support the hypothesis that a functional coupling between postganglionic sympathetic efferent and sensory afferent fibers contributes to the pain.
Beggah Ahmed T   +4 more
doaj   +1 more source

A novel reuptake inhibitor, IP2015, induces erection by increasing central dopamine and peripheral nitric oxide release

open access: yesBritish Journal of Pharmacology, Volume 181, Issue 15, Page 2566-2582, August 2024.
Background and Purpose An estimated 40% of patients with erectile dysfunction have a poor prognosis for improvement with currently available treatments. The present study investigated whether a newly developed monoamine transport inhibitor, IP2015, improves erectile function.
Simon Comerma‐Steffensen   +8 more
wiley   +1 more source

Local haemorrhage induced by Bothrops jararaca venom: relationship to neurogenic inflammation

open access: yesMediators of Inflammation, 2000
We investigated morphological alterations induced by s.c. injection of 2.5 μg of Bothrops jararaca venom in rats. Intense disorganisation of collagen fibres was observed 1 min after the venom injection, particularly at regions near vessels and nerves ...
Luis Roberto C. Gonçalves   +1 more
doaj   +1 more source

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