Demethylation of methylguanidine by a stepwise dioxygenase and lyase reaction [PDF]
Nature CommunicationsGuanidine-responsive riboswitches control genes that enable either detoxification or assimilation of guanidino compounds. In Vreelandella boliviensis and other halophilic bacteria, genes encoding the guanidine carboxylase pathway are found in a guanidine
Malte Sinn +5 more
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From lab reagent to metabolite: the riboswitch ligand guanidine as a relevant compound in bacterial physiology [PDF]
Journal of BacteriologyEfforts of the last 20 years in validating novel riboswitches led to the identification of numerous new motifs recognizing compounds with well-established biological functions.
Payton Bowman, Hubert Salvail
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Improvement in heavy metal removal from aqueous solution using polyetherimide nanofiltration membrane modified by coating approach [PDF]
Journal of Applied Research in Water and Wastewater, 2022 This research focused on improving the antifouling properties and rejection performance of polyetherimide (PEI) nanofiltration membrane by chemical surface modification (surface coating).
Madineh Sadeghipour +2 more
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Guanidine-Containing Antifungal Agents against Human-Relevant Fungal Pathogens (2004–2022)—A Review
Journal of Fungi, 2022 The guanidine moiety is typically a highly basic group, and can be found in a wide variety of drugs, such as zanamivir (Relenza) and metformin (Fortamet), as well as in biologically active compounds for numerous disease areas, including central nervous ...
Simon D. P. Baugh
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Synthesis and Biological Evaluation of Amidinourea Derivatives against Herpes Simplex Viruses
Molecules, 2021 Current therapy against herpes simplex viruses (HSV) relies on the use of a few nucleoside antivirals such as acyclovir, famciclovir and valacyclovir. However, the current drugs are ineffective against latent and drug-resistant HSV infections.
Anita Toscani +6 more
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A variant of guanidine-IV riboswitches exhibits evidence of a distinct ligand specificity
RNA Biology, 2023 Riboswitches are regulatory RNAs that specifically bind a small molecule or ion. Like metabolite-binding proteins, riboswitches can evolve new ligand specificities, and some examples of this phenomenon have been validated.
Felina Lenkeit +5 more
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eLife, 2020 Septin proteins evolved from ancestral GTPases and co-assemble into hetero-oligomers and cytoskeletal filaments. In Saccharomyces cerevisiae, five septins comprise two species of hetero-octamers, Cdc11/Shs1–Cdc12–Cdc3–Cdc10–Cdc10–Cdc3–Cdc12–Cdc11/Shs1 ...
Courtney R Johnson +6 more
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Isopropoxy Benzene Guanidine Kills Staphylococcus aureus Without Detectable Resistance
Frontiers in Microbiology, 2021 Serious infections caused by multidrug-resistant Staphylococcus aureus clearly urge the development of new antimicrobial agents. Drug repositioning has emerged as an alternative approach that enables us to rapidly identify effective drugs.
Xiufeng Zhang +11 more
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Synthesis of pyrimidines using nano-NiZr4 (PO4)6 as a retrievable and robust heterogeneous catalyst [PDF]
Nanochemistry Research, 2020 Nano-NiZr4 (PO4)6 has been used as an effective and retrievable heterogeneous catalyst for the synthesis of pyrimidines through the reaction of benzaldehydes, guanidinehydrochloride and malononitrile under reflux conditions in ethanol.
Hossein Shahbazi-Alavi +1 more
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Dendritic Guanidines as Efficient Analogues of Cell Penetrating Peptides
Pharmaceuticals, 2010 The widespread application of cell penetrating agents to clinical therapeutics and imaging agents relies on the ability to prepare them on a large scale and to readily conjugate them to their cargos. Dendritic analogues of cell penetrating peptides, with
Colin V. Bonduelle, Elizabeth R. Gillies
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