Results 61 to 70 of about 6,045 (297)
Advanced Science, EarlyView.ZDHHC17 palmitoylates CDK4, which together with TRAF6‐mediated ubiquitination, drives cell cycle progression and immune surveillance, revealing a rational combination of CDK4 inhibitors with immune checkpoint blockers for ZDHHC17‐driven cancers. ABSTRACT Uncontrolled cell cycle progression is a hallmark of cancer, tightly regulated by both intrinsic ...
Zekang Wang +7 more
wiley +1 more source
Química Nova, 2007 We report the synthesis of amino(2-hydroxy-2-(4-methoxyphenyl)ethylamino)methaniminium (14) as a direct precursor of a tubastrine derivative (3-dehydroxy-4-methoxytubastrine). The synthetic steps involved functional group interconversions starting from 1-
Kelly de Oliveira Santos +2 more
doaj +1 more source
Berichte der deutschen chemischen Gesellschaft, 1905 n ...
Pellizzari, G., Cantoni, C.
openaire +2 more sources
Cyclic Guanidines as Efficient Organocatalysts for the Synthesis of Polyurethanes
, 2012 A systematic survey of basic/nucleophilic organocatalysts for the polyaddition in bulk of polyols, PEG-600, and PTMO-650, to isophorone diisocyanate (IPDI) has been performed.
Frédéric Robert +11 more
core +1 more source
Advanced Science, EarlyView.Treatment‐resistant wounds caused by polymicrobial biofilms are refractory to conventional therapies due to the dense extracellular matrices. We developed μBLAST, a microblasting wound dressing that combines MnO2‐doped biosilica and a H2O2‐releasing mesh to generate localized oxygen microbubbles that mechanically disrupt biofilms.
Yujin Ahn +12 more
wiley +1 more source
Steuerung der Rotation eines Guanidiniumkations durch Kation‐π‐Wechselwirkungen
Angewandte Chemie, EarlyView.Ein Lanthanid‐π‐Container wurde für die Bindung eines Guanidiniumkations in dessen aromatischer Kavität mittels Kation‐π‐Wechselwirkungen verwendet. Röntgenkristallographie und Festkörper‐NMR‐Spektroskopie bei schneller Rotation um den magischen Winkel wurden verwendet, um die zugrundeliegenden Wirt‐Gast‐Interaktionen zu untersuchen.
Hannah Busch +12 more
wiley +1 more source
Mitochondria targeting molecular transporters: synthesis, lipophilic effect, and ionic complex
Drug Delivery, 2022 As mitochondria are potential therapeutic targeting sites for the treatment of human diseases, delivering cytotoxic drugs, antioxidants, and imaging molecules to mitochondria can provide new therapeutic opportunities.
Akula S. N. Murthy +6 more
doaj +1 more source
, 2015 A cascade silver(I)-catalyzed hydroamination/Michael addition sequence has been developed to deliver highly substituted bicyclic guanidines. This transformation gives rise to geometrically and constitutionally stable ene–guanidines and generates a ...
Catherine M. Serrano (1345548) +4 more
core +1 more source
Controlling the Guanidinium Cation Rotation by Cation–π Interactions
Angewandte Chemie International Edition, EarlyView.A lanthanide π‐container has been employed to trap a guanidinium cation inside the aromatic cavity by cation–π interactions. X‐ray crystallography and solid‐state nuclear magnetic resonance (NMR) spectroscopy at fast magic‐angle spinning (MAS) frequencies have been utilized to probe the underlying host–guest interactions.
Hannah Busch +12 more
wiley +1 more source
Antitumor, Antioxidant and Antimicrobial Studies of Substituted Pyridylguanidines
Molecules, 2013 A series of N-pivaloyl-N′-(alkyl/aryl)-N′′-pyridylguanidine of general formula C4H9CONHC(NR1R2)NPy have been synthesized and characterized using elemental analysis, FT-IR, multinuclear NMR spectroscopy, and in the case of compounds 7 and 11, by single ...
Boris Vabre +7 more
doaj +1 more source