Results 81 to 90 of about 6,480 (239)

Cyclic Guanidines as Efficient Organocatalysts for the Synthesis of Polyurethanes

, 2016
A systematic survey of basic/nucleophilic organocatalysts for the polyaddition in bulk of polyols, PEG-600, and PTMO-650, to isophorone diisocyanate (IPDI) has been performed.
Yacine Ait Ammar (2104891), Eric Cloutet (1500853), Frédéric Robert (1528855), Henri Cramail (1681198), Jérome Alsarraf (2104894), Yannick Landais (1528861)   +5 more
core   +1 more source

Restores Aβ Clearance by Overcoming PCSK9–LRP1 Dysregulation and TRIB3‐Mediated Autophagy Blockade in Alzheimer's Disease

Advanced Science, EarlyView.
PCSK9 upregulation in cerebrovascular endothelial cells and microglia destabilizes the Aβ transporter LRP1, while TRIB3‐associated autophagy blockade further limits intracellular Aβ degradation. A RAP‐modified tea‐polyphenol nanoparticle co‐delivers siPCSK9 and siTRIB3 to restore LRP1‐mediated Aβ efflux and autophagy‐dependent degradation, reducing Aβ ...
Jie Miao, Jing Wang, Yankun Li, Haipei Zhang, Yanli Zhang, Qingnian Li, Bo Xiao, Wenhu Zhou, Junhong Guo   +8 more
wiley   +1 more source

Mitochondria targeting molecular transporters: synthesis, lipophilic effect, and ionic complex

Drug Delivery, 2022
As mitochondria are potential therapeutic targeting sites for the treatment of human diseases, delivering cytotoxic drugs, antioxidants, and imaging molecules to mitochondria can provide new therapeutic opportunities.
Akula S. N. Murthy, Sanket Das, Tejinder Singh, Tae-Wan Kim, Nasim Sepay, Seob Jeon, Jungkyun Im   +6 more
doaj   +1 more source

Synthesis of Bicyclic Guanidines via Cascade Hydroamination/Michael Additions of Mono‑N‑acryloylpropargylguanidines

, 2015
A cascade silver­(I)-catalyzed hydroamination/Michael addition sequence has been developed to deliver highly substituted bicyclic guanidines. This transformation gives rise to geometrically and constitutionally stable ene–guanidines and generates a ...
Catherine M. Serrano (1345548), Ki-Hyeok Kwon (1345545), Louis R. Barrows (1336152), Michael Koch (243521), Ryan E. Looper (1345542)   +4 more
core   +1 more source

Engineered Peptide Self‐Assembled Nanofibers for Enhanced STING Activation: A Promising Nanodelivery Platform for Immunotherapy of Pediatric Solid Tumors

Advanced Science, EarlyView.
An engineered peptide self‐assembled nanofiber platform, designed to replicate STING–cGAMP binding motifs, facilitates pH‐responsive cytosolic delivery of cGAMP, enhances the endoplasmic reticulum with high efficiency, and robustly activates the STING pathway.
Yubin He, Xiao Lu, Chang qing Yang, Ran Zhang, Bo Wan, Xin Ni, Dong Mei   +6 more
wiley   +1 more source

Antitumor, Antioxidant and Antimicrobial Studies of Substituted Pyridylguanidines

Molecules, 2013
A series of N-pivaloyl-N′-(alkyl/aryl)-N′′-pyridylguanidine of general formula C4H9CONHC(NR1R2)NPy have been synthesized and characterized using elemental analysis, FT-IR, multinuclear NMR spectroscopy, and in the case of compounds 7 and 11, by single ...
Boris Vabre, Davit Zargarian, Ghulam Murtaza, Hizbullah Khan, Naseer Ali Shah, Amin Badshah, Muhammad Said, Muhammad Rashid Khan   +7 more
doaj   +1 more source

Dry‑Contact Trimming for All‑Perovskite Tandem Solar Cells via Solid‑Solution Homogenization

Advanced Energy Materials, EarlyView.
Narrow‐bandgap Sn–Pb perovskites are promising bottom absorbers for all‐perovskite tandems but suffer from Sn‐rich surfaces and depth‐dependent lattice/compositional inhomogeneity. Layered‐perovskite‐assisted dry‐contact trimming removes Sn‐rich surface species and reconfigures the Sn–Pb absorber, enabling efficient charge collection, reduced voltage ...
Woocheol Han, Hyojin Hong, Chan Young Kim, Chan Ho Shin, Sung Yong Kim, So Eun Shin, Minhyeok Park, Giseon Yu, Sohyun Kang, Seungmin Lee, Jun Hong Noh   +10 more
wiley   +1 more source

Development of Tartaric Acid Derived Chiral Guanidines and Their Application to Catalytic Enantioselective α‑Hydroxylation of β‑Dicarbonyl Compounds

, 2016
A novel library of chiral guanidines featuring a tartaric acid skeleton was developed from diethyl l-tartrate. These guanidines are easily accessed with tunable steric and electronic properties.
Huanrui Zhang (1944676), Yuming Song (556365), Jingping Qu (556366), Baomin Wang (174006), Hongfang Mu (1944682), Liwei Zou (1944679)   +5 more
core   +1 more source

Redox‐Active Guanidines

ChemElectroChem
Redox‐active guanidines represent compounds with guanidino groups that are stable in at least two different redox states. This unique class of molecules is of significant interest for a variety of research areas, including coordination chemistry ...
Hans‐Jörg Himmel
doaj   +1 more source

Recent development of synthetic preparation methods for guanidines via transition metal catalysis

, 2015
Multisubstituted guanidines have received much attention because of important applications in many fields, such as pharmaceutics, organometallic and coordination chemistry, and organic synthesis.
Xi, Zhenfeng, Zhang, Wen-Xiong, Xu, Ling
core   +1 more source