Results 91 to 100 of about 6,480 (239)
Highly potent, selective acylguanidine-type histamine H2 receptor agonists: synthesis and structure-activity relationships [PDF]
, 2008 Potent and selective histamine H2 receptor (H2R) agonists are valuable pharmacological tools and might be of therapeutic value as drugs, for example in the treatment of severe congestive heart failure.
Kraus, Anja
core +1 more source
Synthetic routes towards guanidines of biological interest
, 2014 THESIS 10430The Rozas laboratory has been interested in the synthesis and biological evaluation of guanidine containing molecules for the past ten years.
Shaw, Julian W.
core
Titanacarborane Amide Catalyzed Transamination of Guanidines
, 2016 This work describes a catalytic transamination of guanidines with a broad substrate scope of primary, secondary, heterocyclic, aliphatic, and aromatic amines, using 5−10 mol % of the half-sandwich titanacarborane amide [σ:η1:η5-(OCH2)(Me2NCH2)C2B9H9]Ti ...
Hao Shen (195461), Zuowei Xie (1425799)
core +1 more source
, 2016 Simple preparation methods of modified guanidines have been explored as potential chiral superbases. Thus, 3,7,8-trisubstituted and 3,6,7,8-tetrasubstituted 1,4,6-triazabicyclooctene systems were prepared from (1S,2S)-1,2-diphenylethylenediamine through ...
Keiko Fukuda (2640976) +5 more
core +2 more sources
Impact of Positively Charged Backbone Modifications on the Properties of Spherical Nucleic Acids. [PDF]
SmallA synthesis of spherical nucleic acids (SNAs) featuring cationic backbone modifications is presented, together with an analysis of their emerging properties. Introducing positively charged guanidinium groups near the SNA surface enhances cellular uptake and offers a pathway toward more precise control over SNA internalization.
Bujold KE +4 more
europepmc +2 more sources
Dendritic Guanidines as Efficient Analogues of Cell Penetrating Peptides
Pharmaceuticals, 2010 The widespread application of cell penetrating agents to clinical therapeutics and imaging agents relies on the ability to prepare them on a large scale and to readily conjugate them to their cargos. Dendritic analogues of cell penetrating peptides, with
Colin V. Bonduelle, Elizabeth R. Gillies
doaj +1 more source
Copper-catalyzed oxidative three-component synthesis of N, N',N″-trisubstituted guanidines.
, 2013 International audienceA copper-catalyzed three-component synthesis of trisubstituted N-aryl guanidines involving cyanamides, arylboronic acids, and amines has been developed. This operationally simple oxidative process, which is performed in the presence
Li, Jihui, Neuville, Luc
core +1 more source
Transition metal-catalyzed N-arylations of amidines and guanidines
, 2012 : Although several recent reviews dealt with transition metal catalyzed N-arylation of amines (all classes), to date no specific review covering the N-arylation of amidines and guanidines appeared.
Rauws, Tom, Maes, Bert
core
Biotechnology and Bioengineering, EarlyView.ABSTRACT Persistence of HCPs remains a major purification challenge in biopharmaceutical manufacturing with direct consequences for product quality, patient safety, and regulatory compliance. Over the last two decades, deeper insights into the mechanisms driving HCP persistence have clarified why certain proteins evade removal during purification ...
Younghoon Oh +10 more
wiley +1 more source
The Practical Synthesis of Double Axial Chiral Guanidines
, 2009 Two novel double axial chiral guanidines were designed according to the concept of double axial chirality. The practical synthetic procedures from (S)-1,1'-binaphthol have been developed.
Guo, Qun-Sheng, Du, Da-Ming
core