Results 21 to 30 of about 1,686 (146)

4492 The role of creatine in developmental myelination and remyelination

Journal of Clinical and Translational Science, 2020
OBJECTIVES/GOALS: Oligodendrocytes (OL) are glial cells of the central nervous system (CNS) responsible for the energy demanding task of generating myelin sheaths during development and remyelination after demyelinating injury.
Lauren Rosko, Victoria N Smith, Jeffrey K. Huang   +2 more
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Transport characteristics of guanidino compounds at the blood-brain barrier and blood-cerebrospinal fluid barrier: relevance to neural disorders

Fluids and Barriers of the CNS, 2011
Guanidino compounds (GCs), such as creatine, phosphocreatine, guanidinoacetic acid, creatinine, methylguanidine, guanidinosuccinic acid, γ-guanidinobutyric acid, β-guanidinopropionic acid, guanidinoethane sulfonic acid and α-guanidinoglutaric acid, are ...
Tachikawa Masanori, Hosoya Ken-ichi
doaj   +1 more source

Additional file 2 of Processing mechanism of guanidinoacetate in choroid plexus epithelial cells: conversion of guanidinoacetate to creatine via guanidinoacetate N-methyltransferase and monocarboxylate transporter 12-mediated creatine release into the CSF

, 2022
Additional file 2. Immunohistochemical staining of GAMT in the rat choroid plexus. Immunohistochemical staining of GAMT was performed in the rat choroid plexus. Nuclei were stained with DAPI (blue). Scale bar: 50 µm.
Jomura, Ryuta, Akanuma, Shin-ichi, Kubo, Yoshiyuki, Tachikawa, Masanori, Hosoya, Ken-ichi   +4 more
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Additional file 1 of Processing mechanism of guanidinoacetate in choroid plexus epithelial cells: conversion of guanidinoacetate to creatine via guanidinoacetate N-methyltransferase and monocarboxylate transporter 12-mediated creatine release into the CSF

, 2022
Additional file 1. Immunohistochemical staining of MCT12 in the rat brain cortex. Double immunohistochemical staining was performed using anti-MCT12 antibodies (red, A and B) and anti-glial fibrillary acidic protein (GFAP) antibodies (green, B) in the rat brain cortex. GFAP is used as a marker of astrocytes. Nuclei were stained with DAPI (blue).
Jomura, Ryuta, Akanuma, Shin-ichi, Kubo, Yoshiyuki, Tachikawa, Masanori, Hosoya, Ken-ichi   +4 more
openaire   +1 more source

Data_Sheet_1_Age-Dependent Decline in Cardiac Function in Guanidinoacetate-N-Methyltransferase Knockout Mice.docx

, 2020
AimGuanidinoacetate N-methyltransferase (GAMT) is the second essential enzyme in creatine (Cr) biosynthesis. Short-term Cr deficiency is metabolically well tolerated as GAMT–/– mice exhibit normal exercise capacity and response to ischemic heart failure.
Debra J. McAndrew (8335134), Thomas R. Eykyn (454146), Julie Wallis (8335137), Stefan Neubauer (88474), Dunja Aksentijević (5660860), Sevasti Zervou (71022), Jurgen E. Schneider (3283935), Craig A. Lygate (8335140)   +7 more
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A Mouse Model of Creatine Transporter Deficiency Reveals Impaired Motor Function and Muscle Energy Metabolism

Frontiers in Physiology, 2018
Creatine serves as fast energy buffer in organs of high-energy demand such as brain and skeletal muscle. L-Arginine:glycine amidinotransferase (AGAT) and guanidinoacetate N-methyltransferase are responsible for endogenous creatine synthesis.
Malte Stockebrand, Malte Stockebrand, Ali Sasani, Ali Sasani, Devashish Das, Sönke Hornig, Irm Hermans-Borgmeyer, Hannah A. Lake, Hannah A. Lake, Dirk Isbrandt, Craig A. Lygate, Craig A. Lygate, Arend Heerschap, Axel Neu, Chi-Un Choe   +14 more
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Guanidinoacetate methyltransferase (GAMT) deficiency: Outcomes in 48 individuals and recommendations for diagnosis, treatment and monitoring [PDF]

, 2014
We collected data on 48 patients from 38 families with guanidinoacetate methyltransferase (GAMT) deficiency. Global developmental delay/intellectual disability (DD/ID) with speech/language delay and behavioral problems as the most affected domains was ...
Konstantopoulou, Vassiliki, Jennifer Mackenzie, Krijn T. Verbruggen, Michael Geraghty, Grant Mitchell, Scaglia, Fernando, Goknur Haliloglu, Bruno Maranda, MacKenzie, Jennifer, Angle, Brad, Coskun, Turgay, Newlove, Theresa, Yuskiv, Nataliya, Luisa Diogo, Theresa Newlove, Aizeddin A. Mhanni, Vassili Valayannopoulos, Barshop, Bruce, Renaud, Deborah, Vassiliki Konstantopoulou, Bruce Barshop, Grolik, Christiane, Mhanni, Aizeddin A., Andrea Schlune, G. Christoph Korenke, Stockler-Ipsiroglu, Sylvia, Schlune, Andrea, Araujo, Helena Caldeira, Deborah Renaud, Iris Marquart, Mitchell, Grant, Verbruggen, Krijn T., Christiane Grolik, van Karnebeek, Clara, Diogo, Luisa, Geraghty, Michael, van Spronsen, Francjan J., Helena Caldeira Araujo, Mercimek-Mahmutoglu, Saadet, LEUZZI, Vincenzo, Levtova, Alina, Turgay Coskun, Andrew Morris, Marquart, Iris, Morris, Andrew, Nicola Longo, Maranda, Bruno, Francjan J. Van Spronsen, Fernando Scaglia, Nataliya Yuskiv, Clara Van Karnebeek, William Nyhan, Brad Angle, Haliloglu, Goknur, Korenke, G. Christoph, Sylvia Stockler Ipsiroglu, Andreas Schulze, Longo, Nicola, Valayannopoulos, Vassili, Alina Levtova, Schulze, Andreas, Saadet Mercimek Mahmutoglu, Nyhan, William   +62 more
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S-Adenosylmethionine: Guanidinoacetate N-Methyltransferase Activities in Livers from Rats with Hormonal Deficiencies or Excesses

Experimental Biology and Medicine, 1973
SummaryS-Adenosylmethionine: guanidinoacetate N-methyltransferase activities were determined in livers from rats after removal of either adrenals, pituitaries, gonads, or thyroids and parathyroids and in livers from intact rats given large doses of either insulin, estradiol, testosterone, cortisol, thyroxine, or growth hormone.
M, Carlson, J F, Van Pilsum
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Mild guanidinoacetate increase under partial guanidinoacetate methyltransferase deficiency strongly affects brain cell development

, 2015
Among cerebral creatine deficiency syndromes, guanidinoacetate methyltransferase (GAMT) deficiency can present the most severe symptoms, and is characterized by neurocognitive dysfunction due to creatine deficiency and accumulation of guanidinoacetate in
Braissant, Olivier, Béard, Elidie, Hanna-El-Daher, Layane, Henry, Hugues, Tenenbaum, Liliane   +4 more
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In vitro study of uptake and synthesis of creatine and its precursors by cerebellar granule cells and astrocytes suggests some hypotheses on the physiopathology of the inherited disorders of creatine metabolism

BMC Neuroscience, 2012
Background The discovery of the inherited disorders of creatine (Cr) synthesis and transport in the last few years disclosed the importance of blood Cr supply for the normal functioning of the brain.
Carducci Claudia, Carducci Carla, Santagata Silvia, Adriano Enrico, Artiola Cristiana, Thellung Stefano, Gatta Elena, Robello Mauro, Florio Tullio, Antonozzi Italo, Leuzzi Vincenzo, Balestrino Maurizio   +11 more
doaj   +1 more source