Results 191 to 200 of about 201,610 (282)

Adverse Outcome Pathways Applied to Space Radiation Research

Environmental and Molecular Mutagenesis, EarlyView.
ABSTRACT Long‐duration spaceflight exposes astronauts to various stressors that can alter human physiology, potentially causing immediate and long‐term health effects. These stressors can damage biomolecules, cells, tissues, and organs, leading to adverse outcomes.
Vinita Chauhan, Veronica S. Grybas, Devyn Hoopfer, Casey Higginson, Elizabeth A. Ainsbury, Omid Azimzadeh, Afshin Beheshti, Steve Blattnig, Marjan Boerma, Sylvain V. Costes, Stephen Doty, Christelle Adam‐Guillermin, Nobuyuki Hamada, Patricia Hinton, Janice L. Huff, Robert Reynolds, Ruth C. Wilkins, Scott Wood, Carole L. Yauk   +18 more
wiley   +1 more source

Selectivity of action of an antiherpetic agent, 9-(2-hydroxyethoxymethyl) guanine.

Proceedings of the National Academy of Sciences of the United States of America, 1977
G. Elion, P. Furman, J. A. Fyfe, P. Miranda, L. Beauchamp, H. Schaeffer   +5 more
semanticscholar   +1 more source

Targeting NAT10 Inhibits Hepatocarcinogenesis via ac4C‐Mediated SMAD3 mRNA Stability

Exploration, EarlyView.
This study demonstrates that elevated N‐acetyltransferase 10 (NAT10) expression stabilizes SMAD3 mRNA through ac4C modification, promoting the progression of hepatocellular carcinoma (HCC). NAT10 also activates the TGF‐β signaling pathway, facilitating epithelial‐to‐mesenchymal transition and inhibiting anoikis. Furthermore, the authors develop a small‐
Yigan Zhang, Yanbin Dong, Shuwen Chen, Hao Deng, Weiru Yu, Bonan Chen, Minjie Chen, Wanglong Liu, Xiao Tan, Jiaxin Ni, Daniel Rigden, Xuan Wang, Wuhua Zhou, Jia Meng, Juan Chen, Yuanchao Xue, Zhongji Meng   +16 more
wiley   +1 more source

Metabolite‐Guided Acetylation Therapy: Astragaloside IV Reverses Diabetic Nephropathy via Gna13‐Driven Purine Metabolic Reprogramming

Food Frontiers, EarlyView.
This study unveils how ASIV reverses diabetic nephropathy by restoring Gna13‐K363 acetylation and reprogramming purine metabolism. Using spatial metabolomics and acetylproteomics, we identified zonation‐specific purine dysregulation in diabetic kidneys, with ASIV normalizing metabolite distribution (hypoxanthine, cAMP, guanine) and targeting Gna13 ...
Shi Qiu, Sifan Guo, Dandan Xie, Zhibo Wang, Ying Cai, Xian Wang, Qiang Yang, Chunsheng Lin, Hong Yao, Qiqi Zhao, Yu Guan, Songqi Tang, Yiqiang Xie, Aihua Zhang   +13 more
wiley   +1 more source

Comparative Analysis of Differential Metabolites in Panax quinquefolius From China and the United States Using UPLC‐Orbitrap‐MS and LC‐MS/MS

Food Safety and Health, EarlyView.
trans‐ferulic acid and sinapic acid could be used to distinguish Chinese ginseng from American ginseng. Panax quinquefolius from China and the United States produced unique metabolites and phenolic compounds. ABSTRACT Currently, there is a relative paucity of comparative studies on the metabolites of American ginseng from different geographical sources.
Dan Li, Ling Xie, Fan Li, Haoran Li, Zhipeng Zhang, Yi Peng, Liang Gong   +6 more
wiley   +1 more source

Altered Inflammatory Signature in a C9ORF72‐ALS iPSC‐Derived Motor Neuron and Microglia Coculture Model

Glia, EarlyView.
Established a C9ORF72 ALS microglia and motor neuron coculture model. Identified an altered inflammatory signature in C9ORF72 ALS microglia. Single‐cell RNA sequencing detected the removal of an LPS responsive microglia subpopulation. ABSTRACT Amyotrophic lateral sclerosis (ALS) is a complex neurodegenerative disorder involving multiple cell types in ...
Yujing Gao, Jessica L. Brothwood, Harpreet Saini, Gregory A. O'Sullivan, Carla F. Bento, James M. McCarthy, Nicola G. Wallis, Elena Di Daniel, Brent Graham, Daniel M. Tams   +9 more
wiley   +1 more source

Oxidation of the Guanine Nucleotide Pool Underlies Cell Death by Bactericidal Antibiotics

Science, 2012
James J Foti, Babho Devadoss, J. Winkler, J. Collins, G. Walker   +4 more
semanticscholar   +1 more source

Long‐term impact of stressful life events on breast cancer risk: A 36‐year genetically informed prospective study in the Finnish Twin Cohort

International Journal of Cancer, EarlyView.
What's New? Breast cancer results from a combination of genetic and environmental causes, and the cumulative effect of stressful life events may be a contributing factor. Here, the authors analyzed data from cohort and twin‐pair studies including 36 years of follow‐up to find out how stressful life events affect breast cancer risk. They found that even
Elissar Azzi, Hannes Bode, Teemu Palviainen, Mikaela Hukkanen, Miina Ollikainen, Jaakko Kaprio   +5 more
wiley   +1 more source

mtFFPECleaner: A high‐fidelity machine learning approach for artifact removal in high‐throughput mitochondrial DNA sequencing data of archival formalin‐fixed paraffin‐embedded specimens

Interdisciplinary Medicine, EarlyView.
mtFFPECleaner is a high‐fidelity machine learning framework designed to remove formalin‐induced artifacts in mitochondrial DNA sequencing data from formalin‐fixed paraffin‐embedded (FFPE) tissue samples. Using paired FFPE‐fresh‐frozen samples, the model distinguishes genuine mtDNA mutations from artifacts through feature extraction and random forest ...
Shengjing Li, Wenjie Guo, Tianlei Sun, Fanfan Xie, Fan Peng, Kaixiang Zhou, Zhangwen Lei, Xu Guo, Yang Liu, Jinliang Xing   +9 more
wiley   +1 more source

Central Nervous System Involvement as the Initial Manifestation of Transthyretin Amyloidosis: A Case Report and Literature Review

iRADIOLOGY, EarlyView.
We reported a patient who presented with transient focal neurological symptoms. The contrast‐enhanced brain magnetic resonance imaging (MRI) of this patient demonstrated significant enhancement of the dura mater, pia mater, and spinal meninges. Based on the positive result of single photon emission computed tomography (SPECT), we promptly determined ...
Fen Li, Mingsheng Wan, Benjian Sun, Lijia Zou, Huan Yang, Jing Li, Si Chen   +6 more
wiley   +1 more source