Results 1 to 10 of about 90,710 (248)

Scambio, a novel guanine nucleotide exchange factor for Rho [PDF]

Molecular Cancer, 2004
Background Small GTPases of the Rho family are critical regulators of various cellular functions including actin cytoskeleton organization, activation of kinase cascades and mitogenesis.
Groffen John, Senadheera Dinithi, Haataja Leena, Hemmeryckx Bianca, Curtis Christina, Heisterkamp Nora   +5 more
doaj   +4 more sources

Retraction: Gonzalez, G.; Chen, L. EFA6 in Axon Regeneration, as a Microtubule Regulator and as a Guanine Nucleotide Exchange Factor. Cells 2021, 10, 1325 [PDF]

Cells, 2022
The journal retracts the article “Retraction: Gonzalez, G.; Chen, L. EFA6 in Axon Regeneration, as a Microtubule Regulator and as a Guanine Nucleotide Exchange Factor” [...]
Gilberto Gonzalez, Lizhen Chen
doaj   +2 more sources

Correction: The Guanine Nucleotide Exchange Factor RIC8 Regulates Conidial Germination through Gα Proteins in. [PDF]

PLoS ONE, 2013
Heterotrimeric G protein signaling is essential for normal hyphal growth in the filamentous fungus Neurospora crassa. We have previously demonstrated that the non-receptor guanine nucleotide exchange factor RIC8 acts upstream of the Gα proteins GNA-1 and
Carla J. Eaton, Ilva E. Cabrera, Jacqueline A. Servin, Sara J. Wright, Murray P. Cox, Katherine A. Borkovich   +5 more
doaj   +13 more sources

Structure of the G protein chaperone and guanine nucleotide exchange factor Ric-8A bound to Gαi1 [PDF]

Nature Communications, 2020
Ric-8A is guanine nucleotide exchange factor (GEF) that also acts as a folding chaperone for its Gα subunit. Here, the authors present the structure of Ric-8A bound to nucleotide-free Gαi1, revealing the mechanism by which Ric-8A exerts both GEF and ...
Levi J. McClelland, Kaiming Zhang, Tung-Chung Mou, Jake Johnston, Cindee Yates-Hansen, Shanshan Li, Celestine J. Thomas, Tzanko I. Doukov, Sarah Triest, Alexandre Wohlkonig, Gregory G. Tall, Jan Steyaert, Wah Chiu, Stephen R. Sprang   +13 more
doaj   +2 more sources

Regulation of mitotic spindle formation by the RhoA guanine nucleotide exchange factor ARHGEF10 [PDF]

BMC Cell Biology, 2009
Background The Dbl family guanine nucleotide exchange factor ARHGEF10 was originally identified as the product of the gene associated with slowed nerve-conduction velocities of peripheral nerves.
Satoh Takaya, Kataoka Tohru, Ueda Shuji, Aoki Takuji   +3 more
doaj   +2 more sources

Regulation of Rho guanine nucleotide exchange factor 3 by phosphorylation in the PH domain [PDF]

iScience
Summary: Although most members of the Rho guanine nucleotide exchange factor (RhoGEF) family are found to be phosphorylated, how phosphorylation regulates RhoGEF function is poorly understood.
Jesus F. Moreno, Jae-Sung You, Carlos C. Rodriguez, Shashank Pant, Adriana Reyes-Ordoñez, Reean Abdullah, Nilmani Singh, Maxine J. van der Donk, Emad Tajkhorshid, Jie Chen   +9 more
doaj   +2 more sources

Structural determinants of Rab11 activation by the guanine nucleotide exchange factor SH3BP5 [PDF]

Nature Communications, 2018
Rab11 GTPases are involved in various cellular processes but their activation by guanine nucleotide exchange factors (GEFs) is not fully understood.
Meredith L. Jenkins, Jean Piero Margaria, Jordan T. B. Stariha, Reece M. Hoffmann, Jacob A. McPhail, David J. Hamelin, Martin J. Boulanger, Emilio Hirsch, John E. Burke   +8 more
doaj   +2 more sources

Role of the Guanine Nucleotide Exchange Factor GBF1 in the Replication of RNA Viruses [PDF]

Viruses, 2020
The guanine nucleotide exchange factor GBF1 is a well-known factor that can activate different ADP-ribosylation factor (Arf) proteins during the regulation of different cellular vesicular transport processes.
José L. Martínez, Carlos F. Arias
doaj   +2 more sources

Nuclear Vav3 is required for polycomb repression complex-1 activity in B-cell lymphoblastic leukemogenesis

Nature Communications, 2022
Ph+ and Ph-like B-ALL remain poor prognosis leukemias. VAV3, a guanine nucleotide exchange factor, is activated and overexpressed in these leukemias. Here the authors reveal that leukemic VAV3 is predominantly nuclear.
R. C. Nayak, K. H. Chang, A. K. Singh, M. Kotliar, M. Desai, A. M. Wellendorf, M. Wunderlich, J. Bartram, B. Mizukawa, M. Cuadrado, P. Dexheimer, A. Barski, X. R. Bustelo, N. N. Nassar, J. A. Cancelas   +14 more
doaj   +1 more source

ADP-Ribosylation Factor Family of Small GTP-Binding Proteins: Their Membrane Recruitment, Activation, Crosstalk and Functions

Frontiers in Cell and Developmental Biology, 2022
Members of the ADP-ribosylation factor (ARF) family of guanine-nucleotide binding proteins play critical roles in various cellular processes, especially in regulating the secretory, and endocytic pathways.
Tiantian Li, Yusong Guo, Yusong Guo, Yusong Guo   +3 more
doaj   +1 more source