Guanine nucleotide exchange factors and colon neoplasia [PDF]
Frontiers in Cell and Developmental BiologyDespite many diagnostic and therapeutic advances, colorectal cancer (CRC) remains the second leading cause of cancer death for men and women in the United States.
Lea-Pearl Njei +8 more
doaj +7 more sources
Intermediates in the Guanine Nucleotide Exchange Reaction of Rab8 Protein Catalyzed by Guanine Nucleotide Exchange Factors Rabin8 and GRAB [PDF]
Journal of Biological Chemistry, 2013 Small G-proteins of the Ras superfamily control the temporal and spatial coordination of intracellular signaling networks by acting as molecular on/off switches. Guanine nucleotide exchange factors (GEFs) regulate the activation of these G-proteins through catalytic replacement of GDP by GTP.
Zhong Guo, Roger S Goody, Aymelt Itzen
exaly +10 more sources
Activation of G Proteins by Guanine Nucleotide Exchange Factors Relies on GTPase Activity. [PDF]
PLoS ONE, 2016 G proteins are an important family of signalling molecules controlled by guanine nucleotide exchange and GTPase activity in what is commonly called an 'activation/inactivation cycle'.
Rob J Stanley, Geraint M H Thomas
doaj +4 more sources
RasGRP Ras guanine nucleotide exchange factors in cancer. [PDF]
Front Biol (Beijing), 2013 RasGRP proteins are activators of Ras and other related small GTPases by the virtue of functioning as guanine nucleotide exchange factors (GEFs). In vertebrates, four RasGRP family members have been described. RasGRP-1 through -4 share many structural domains but there are also subtle differences between each of the different family members.
Ksionda O, Limnander A, Roose JP.
europepmc +7 more sources
Optogenetic modulation of guanine nucleotide exchange factors of Ras superfamily proteins directly controls cell shape and movement [PDF]
Frontiers in Cell and Developmental Biology, 2023 In this article, we provide detailed protocols on using optogenetic dimerizers to acutely perturb activities of guanine nucleotide exchange factors (GEFs) specific to Ras, Rac or Rho small GTPases of the migratory networks in various mammalian and amoeba
Dhiman Sankar Pal +10 more
doaj +2 more sources
GPCRs that Rhoar the Guanine nucleotide exchange factors. [PDF]
Small GTPases, 2022 Cell migration, a crucial step in numerous biological processes, is tightly regulated in space and time. Cells employ Rho GTPases, primarily Rho, Rac, and Cdc42, to regulate their motility. Like other small G proteins, Rho GTPases function as biomolecular switches in regulating cell migration by operating between GDP bound 'OFF' and GTP bound 'ON ...
Omble A, Kulkarni K.
europepmc +3 more sources
The Emerging Role of Rho Guanine Nucleotide Exchange Factors in Cardiovascular Disorders: Insights Into Atherosclerosis: A Mini Review [PDF]
Frontiers in Cardiovascular Medicine, 2022 Atherosclerosis is a leading cause of cardiovascular disease, and atherosclerotic cardiovascular disease accounts for one-third of global deaths. However, the mechanism of atherosclerosis is not fully understood.
Mengqi Li +9 more
doaj +2 more sources
The Emerging Role of Guanine Exchange Factors in ALS and other neurodegenerative diseases [PDF]
Frontiers in Cellular Neuroscience, 2014 Small GTPases participate in a broad range of cellular processes such as proliferation, differentiation and migration. The exchange of GDP for GTP resulting in the activation of these GTPases is catalyzed by a group of enzymes called guanine nucleotide ...
Cristian eDroppelmann +5 more
doaj +2 more sources
Guanine Nucleotide Exchange Factors and Small GTPases: Their Regulation and Functions, Diseases, and Therapeutic Targets [PDF]
MedCommGuanine nucleotide exchange factors (GEFs) and their small GTPase substrates constitute a fundamental regulatory system that governs diverse cellular processes, including cytoskeletal dynamics, membrane trafficking, and transcriptional regulation.
Zexing Lin +15 more
doaj +2 more sources
Differential Rac1 signalling by guanine nucleotide exchange factors implicates FLII in regulating Rac1-driven cell migration [PDF]
Nature Communications, 2016 The small GTPase Rac1 regulates various cellular processes, including cell migration. However, Rac1 can have opposing migratory effects. Here the authors show that two guanine nucleotide exchange factors, Tiam1 and P-Rex1, differentially regulate the ...
Hadir Marei +7 more
doaj +2 more sources