Results 31 to 40 of about 9,354,840 (235)

Chlamydial entry involves TARP binding of guanine nucleotide exchange factors.

PLoS Pathogens, 2008
Chlamydia trachomatis attachment to cells induces the secretion of the elementary body-associated protein TARP (Translocated Actin Recruiting Protein).
B Josh Lane, Charla Mutchler, Souhaila Al Khodor, Scott S Grieshaber, Rey A Carabeo   +4 more
doaj   +1 more source

Clinical implication and potential function of ARHGEF6 in acute myeloid leukemia: An in vitro study.

PLoS ONE, 2023
The roles of Rho GTPases in various types of cancer have been extensively studied, but the research of Rho guanine nucleotide exchange factors (GEFs) in cancer is not comprehensive.
Kang Li, Haiquan Wang, Chaofan Yang, Chaojun Li, Bin Xue, Jiankui Zhou   +5 more
doaj   +1 more source

Lipocalin‐2 activates hepatic stellate cells and promotes nonalcoholic steatohepatitis in high‐fat diet–fed Ob/Ob mice

Hepatology, EarlyView., 2022
Graphical summary of obesity‐induced NASH progression by LCN2 targeted to HSC activation. Abstract Background and Aims In obesity and type 2 diabetes mellitus, leptin promotes insulin resistance and contributes to the progression of NASH via activation of hepatic stellate cells (HSCs).
Kyung Eun Kim, Jaewoong Lee, Hyun Joo Shin, Eun Ae Jeong, Hye Min Jang, Yu Jeong Ahn, Hyeong Seok An, Jong Youl Lee, Meong Cheol Shin, Soo Kyoung Kim, Won Gi Yoo, Won Ho Kim, Gu Seob Roh   +12 more
wiley   +1 more source

Overexpression of RAPGEF3 enhances the therapeutic effect of dezocine in treatment of neuropathic pain

Genetics and Molecular Biology, 2021
Pain is a significant problem worldwide that affects the quality of life of patients. Dezocine is a non-addictive analgesic drug with kappa-opioid antagonist activity and has been successfully used to alleviate of postoperative pain.
Xue Liu, Li Song, Xiaojun Ma, Yong Liu, Hui Huang, Yongsheng Xu, Wei Yan   +6 more
doaj   +1 more source

Janus kinase 2 inhibition by pacritinib as potential therapeutic target for liver fibrosis

Hepatology, EarlyView., 2022
Diagram of the activation of the profibrotic and procontractile Janus kinase 2 (JAK2)/Ras homolog family member A/Rho‐kinase pathway and the inhibition of phosphorylated JAK2 by pacritinib to inhibit hepatic stellate cell activity. Abstract Background and Aims Janus kinase 2 (JAK2) signaling is increased in human and experimental liver fibrosis with ...
Sandra Torres, Cristina Ortiz, Nadine Bachtler, Wenyi Gu, Leon D. Grünewald, Nico Kraus, Robert Schierwagen, Christoph Hieber, Caroline Meier, Olaf Tyc, Maximilian Joseph Brol, Frank Erhard Uschner, Bart Nijmeijer, Christoph Welsch, Marie‐Luise Berres, Carmen Garcia‐Ruiz, Jose Carlos Fernandez‐Checa, Christian Trautwein, Thomas J. Vogl, Stefan Zeuzem, Jonel Trebicka, Sabine Klein   +21 more
wiley   +1 more source

ARHGEF4-mediates the actin cytoskeleton reorganization of hepatic stellate cells in 3-dimensional collagen matrices

Cell Adhesion & Migration, 2019
The actin cytoskeleton of hepatic stellate cells (HSCs) is reorganized when they are cultured in 3D collagen matrices. Here, we investigated the molecular mechanism of actin cytoskeleton reorganization in HSCs cultured in 3D floating collagen matrices ...
Xiaowei Zhang, Lan Sun, Wei Chen, Shanna Wu, Yanmeng Li, Xiaojin Li, Bei Zhang, Jingyi Yao, Huan Wang, Anjian Xu   +9 more
doaj   +1 more source

An evolutionary ratchet leading to loss of elongation factors in eukaryotes [PDF]

, 2014
Background The GTPase eEF1A is the eukaryotic factor responsible for the essential, universal function of aminoacyl-tRNA delivery to the ribosome.
Kamenski, Piotr, Atkinson, Gemma C.,, Atkinson, Gemma C., Soosaar, Axel, Hauryliuk, Vasili,, Ivan Chicherin, Martin Carr, Tenson, Tanel,, Vasili Hauryliuk, Carr, Martin, Tanel Tenson, Kamenski, Piotr,, Kuzmenko, Anton, Hauryliuk, Vasili, Tenson, Tanel, Kuzmenko, Anton,, Chicherin, Ivan,, Carr, Martin,, Piotr Kamenski, Gemma C Atkinson, Soosaar, Axel,, Anton Kuzmenko, Lund University., Axel Soosaar, Chicherin, Ivan   +24 more
core   +1 more source

Phenotype and genotype spectrum of variants in guanine nucleotide exchange factor genes in a broad cohort of Iranian patients

Molecular Genetics & Genomic Medicine, 2022
Background Guanine nucleotide exchange factors (GEFs) play pivotal roles in neuronal cell functions by exchanging GDP to GTP nucleotide and activation of GTPases.
Meysam Mosallaei, Naeim Ehtesham, Maryam Beheshtian, Shahrouz Khoshbakht, Behzad Davarnia, Kimia Kahrizi, Hossein Najmabadi   +6 more
doaj   +1 more source

The many faces of the guanine-nucleotide exchange factor trio [PDF]

Cell Adhesion & Migration, 2012
Small Rho-GTPases are enzymes that are bound to GDP or GTP, which determines their inactive or active state, respectively. The exchange of GDP for GTP is catalyzed by so-called Rho-guanine nucleotide exchange factors (GEFs). Rho-GEFs are characterized by a Dbl-homology (DH) and adjacent Pleckstrin-homology (PH) domain that serves as enzymatic unit for ...
van Rijssel, Jos, van Buul, Jaap D.
openaire   +3 more sources

Novel regulation of mitotic exit by the Cdc42 effectors Gic1 and Gic2 [PDF]

, 2004
Copyright @ The Rockefeller University PressThe guanine nucleotide exchange factor Cdc24, the GTPase Cdc42, and the Cdc42 effectors Cla4 and Ste20, two p21-activated kinases, form a signal transduction cascade that promotes mitotic exit in yeast.
Höfken, T, Thomas Höfken, Schiebel, E, Elmar Schiebel, Höfken, Thomas, Schiebel, Elmar   +5 more
core   +1 more source